Presentation_1_Association between caregiver ability and quality of life for people with inflammatory bowel disease: The mediation effect of positive feelings of caregivers.pdf

Inflammatory bowel disease (IBD) is an incurable digestive disease. Since patients have to live with it, improving patients’ quality of life is important. Caregiver’s positive feelings and closeness may have a positive effect on patients’ quality of life. We hypothesized that caregiver’s positive feeling affected patient’s quality of life through caregiver’s caring ability, and closeness might be the upstream of this chain. In this study, we conducted a single-center cross-sectional survey by questionnaire in China to tested the hypothesis. A total of 181 patient-caregiver pairs were included. The short version of the IBD questionnaire (SIBDQ), the twelve-item short-form health survey (SF-12), the positive aspects of caregiving (PAC) and Capacity Scale of caregivers were used to collect data. All the data were collected in one interview. Spearman correlation and Bootstrap method were used to analyze the data. Mediation analysis results indicated that caregiver’s caring ability mediated the association between caregiver’s positive feelings and patients’ quality of life (p < 0.01), which explained 34.1% of the total variation of patients’ quality of life. Mediation analysis results also revealed that patient-evaluated or caregiver-evaluated closeness had a positive effect on patients’ quality of life through caregiver’s positive feeling and caregiver’s caring ability (p < 0.05), which explained 2.1 and 2.3% of the variation of patients’ quality of life. Caregiver’s positive feelings were related to caregivers’ quality of life (p < 0.01), but there was no significant association between caregivers’ ability and caregivers’ quality of life. In summary, our model revealed that caregiver’s positive feeling affected patients’ quality of life through caregiver’s caring ability.</p

Combined mutations profilesof BCP/precorein the HBeAgseroconversion children and adult patients.

<p>Mutation ratio was the ratio of the number of specific linkage mutation type to the total sample number. <i>P</i>_<i>1</i> value, <i>P</i>_<i>1</i> represented the statistics difference of certain linkage mutation ratio between the HBeAg positive children patients and HBeAg negative children patients. <i>P</i>_<i>2</i> represented the statistics difference of certain linkage mutation ratio between HBeAg positive adult patient and HBeAg negative adult patients. <i>P</i>_<i>3</i> represented the statistics difference of certain linkage mutation ratio between HBeAg negative children patients and HBeAg negative adult patients.</p><p>Combined mutations profilesof BCP/precorein the HBeAgseroconversion children and adult patients.</p

The clinical information of chronic hepatitis B patients.

<p>The clinical information of chronic hepatitis B patients.</p

Mutation sites with >5% ratio in BCP/precore region.

<p>Mutation sites with >5% ratio in BCP/precore region.</p

The relationship between number of mutation in BCP/precore region and e antigen seroconversion status.

<p>A. Average number of mutations nucleotides in BCP/precore region in children and adultpatients with CHB, Average number of mutations in BCP/precore regions of HBeAg negative patients were obviously higher than in HBeAg positive patients either in adult and children patients group; Average number of mutations in BCP/precore regions of adult HBeAg negative patients was also statistical higher than that of children HBeAg negative patients. B. Correlations between the number of mutant sites in BCP/precore and HBeAg seroconversion.red line representedthe correlation between BCP/precore mutation count and HBeAg negative ratio in children patients, <i>P</i><0.001; blue line represented the correlation between precore/core mutation count and HBeAg negative ratio in adult patients, <i>P</i><0.001.</p

Robotic versus Open Gastrectomy for Gastric Cancer: A Meta-Analysis

<div><p>Aim</p><p>To evaluate the safety and efficacy of robotic gastrectomy versus open gastrectomy for gastric cancer.</p> <p>Methods</p><p>A comprehensive search of PubMed, EMBASE, Cochrane Library, and Web of Knowledge was performed. Systematic review was carried out to identify studies comparing robotic gastrectomy and open gastrectomy in gastric cancer. Intraoperative and postoperative outcomes were also analyzed to evaluate the safety and efficacy of the surgery. A fixed effects model or a random effects model was utilized according to the heterogeneity.</p> <p>Results</p><p>Four studies involving 5780 patients with 520 (9.00%) cases of robotic gastrectomy and 5260 (91.00%) cases of open gastrectomy were included in this meta-analysis. Compared to open gastrectomy, robotic gastrectomy has a significantly longer operation time (weighted mean differences (WMD) =92.37, 95% confidence interval (CI): 55.63 to 129.12, P<0.00001), lower blood loss (WMD: -126.08, 95% CI: -189.02 to -63.13, P<0.0001), and shorter hospital stay (WMD = -2.87; 95% CI: -4.17 to -1.56; P<0.0001). No statistical difference was noted based on the rate of overall postoperative complication, wound infection, bleeding, number of harvested lymph nodes, anastomotic leakage and postoperative mortality rate.</p> <p>Conclusions</p><p>The results of this meta-analysis suggest that robotic gastrectomy is a better alternative technique to open gastrectomy for gastric cancer. However, more prospective, well-designed, multicenter, randomized controlled trials are necessary to further evaluate the safety and efficacy as well as the long-term outcome.</p> </div

Funnel plot of overall postoperative complication rate in patients between RG and OG.

<p>OR, odds ratio; SE, standard error.</p

Forest plot showing a meta-analysis for robotic gastrectomy versus open gastrectomy on A. Postoperative hospital stay; B. Overall postoperative complication rate; C. Anastomotic leakage; D. Wound infection; E. Bleeding; F. Postoperative mortality.

<p>Forest plot showing a meta-analysis for robotic gastrectomy versus open gastrectomy on A. Postoperative hospital stay; B. Overall postoperative complication rate; C. Anastomotic leakage; D. Wound infection; E. Bleeding; F. Postoperative mortality.</p

Flow chart of selection.

<p>Flow chart of selection.</p

DataSheet_1_Ribosomal Protein L23 Drives the Metastasis of Hepatocellular Carcinoma via Upregulating MMP9.docx

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths globally. Tumor metastasis is one of the major causes of high mortality of HCC. Identifying underlying key factors contributing to invasion and metastasis is critical to understand the molecular mechanisms of HCC metastasis. Here, we identified RNA binding protein L23 (RPL23) as a tumor metastasis driver in HCC. RPL23 was significantly upregulated in HCC tissues compared to adjacent normal tissues, and closely related to poor clinical outcomes in HCC patients. RPL23 depletion inhibited HCC cell proliferation, migration and invasion, and distant metastasis. Mechanistically, RPL23 directly associated with 3’UTR of MMP9, therefore positively regulated MMP9 expression. In conclusion, we identified that RPL23 might play an important role in HCC metastasis in an MMP9-dependent manner and be a potential therapeutic target for HCC tumorigenesis and metastasis.</p