Research progress in intravesical instillation for non-muscle invasive bladder cancer

Bladder cancer is the most common malignant tumor of the urinary system， which seriously affects patients’ health and life. Transurethral resection of bladder tumor is the main treatment for non-muscle invasive bladder cancer （NMIBC）， whereas high recurrence rate after surgery remains the main challenge. To prevent tumor recurrence， intravesical instillation is often performed postoperatively by clinicians. In this article， traditional intravesical instillation， new drugs and therapeutic regimens were illustrated and summarized， aiming to provide valuable reference for clinical treatment of NMIBC

A Meta-Analysis of the Use of Genetically Modified Cotton and Its Conventional in Agronomy Aspect and Economic Merits

Rising the area of growing Genetically Modified (GM) cotton mostly derived from the yield gain and income gain both GM cotton and conventional cotton is affected by seed cost, pesticide cost, management and labor cost. Therefore, planting GM cotton should be considering both agronomy aspect in yield gain and economic dimension in income gain. Those aspects are not only for GM cotton but also for conventional cotton. This paper is a meta-analysis as a synthesis of current research by searching literature both peer-reviewed and non peer-reviewed. A meta-analysis depicted that individual study mostly favor GM cotton in yield gain, seed cost and pesticide cost. However, in terms of pesticide cost a meta-analysis prone to favor non GM cotton. Moreover, a meta-analysis revealed that the positive impact in the differences of GM cotton and conventional cotton as the evidence of the publication is highly significant. Key Words : Genetically Modified, Cotton, Conventional, Yield, Income, Gain, Meta-Analysi

Genome sequence of the cultivated cotton <i>Gossypium arboreum</i>

The complex allotetraploid nature of the cotton genome (AADD; 2n = 52) makes genetic, genomic and functional analyses extremely challenging. Here we sequenced and assembled the Gossypium arboreum (AA; 2n = 26) genome, a putative contributor of the A subgenome. A total of 193.6 Gb of clean sequence covering the genome by 112.6-fold was obtained by paired-end sequencing. We further anchored and oriented 90.4% of the assembly on 13 pseudochromosomes and found that 68.5% of the genome is occupied by repetitive DNA sequences. We predicted 41,330 protein-coding genes in G. arboreum. Two whole-genome duplications were shared by G. arboreum and Gossypium raimondii before speciation. Insertions of long terminal repeats in the past 5 million years are responsible for the twofold difference in the sizes of these genomes. Comparative transcriptome studies showed the key role of the nucleotide binding site (NBS)-encoding gene family in resistance to Verticillium dahliae and the involvement of ethylene in the development of cotton fiber cells.Genetics &amp; HereditySCI(E)[email protected]; [email protected]; [email protected]

GWAS Analysis and QTL Identification of Fiber Quality Traits and Yield Components in Upland Cotton Using Enriched High-Density SNP Markers

It is of great importance to identify quantitative trait loci (QTL) controlling fiber quality traits and yield components for future marker-assisted selection (MAS) and candidate gene function identifications. In this study, two kinds of traits in 231 F6:8 recombinant inbred lines (RILs), derived from an intraspecific cross between Xinluzao24, a cultivar with elite fiber quality, and Lumianyan28, a cultivar with wide adaptability and high yield potential, were measured in nine environments. This RIL population was genotyped by 122 SSR and 4729 SNP markers, which were also used to construct the genetic map. The map covered 2477.99 cM of hirsutum genome, with an average marker interval of 0.51 cM between adjacent markers. As a result, a total of 134 QTLs for fiber quality traits and 122 QTLs for yield components were detected, with 2.18–24.45 and 1.68–28.27% proportions of the phenotypic variance explained by each QTL, respectively. Among these QTLs, 57 were detected in at least two environments, named stable QTLs. A total of 209 and 139 quantitative trait nucleotides (QTNs) were associated with fiber quality traits and yield components by four multilocus genome-wide association studies methods, respectively. Among these QTNs, 74 were detected by at least two algorithms or in two environments. The candidate genes harbored by 57 stable QTLs were compared with the ones associated with QTN, and 35 common candidate genes were found. Among these common candidate genes, four were possibly “pleiotropic.” This study provided important information for MAS and candidate gene functional studies

Structure of Sewage Sludge-Clay Multiscale Composite Particles to Control the Mechanism of SO2 and H2S Gas Release

In order to address the problem of sulfur gas and other odors released in the process of using sewage sludge as a construction material, this study prepared multiscale composite particles with a &ldquo;large scale-medium scale-small scale-micro scale&rdquo; structure by mixing sludge with silica-alumina building materials. Analysis of the structural changes formed by the internal gas of composite particles due to diffusion at different temperatures and a study of the characteristics of SO2 and H2S release from composite particles were conducted, as well as being compared with the release characteristics of pure sludge, which clarified the mechanism of controlling sulfur-containing-gas release from composite particles. The results showed that compared with pure sludge, the sludge-clay multiscale composite particles were able to reduce the release of SO2 and H2S up to 90% and 91%, and the release temperatures of SO2 and H2S were increased to 120 &deg;C and 80 &deg;C, respectively. Meanwhile, the special structure of the sludge-clay multiscale composite particles and the clay composition are the main factors that hinder the diffusion of sludge pyrolysis gases. Additionally, there are three layers of &ldquo;gray surface layer-black mixed layer-dark gray spherical core&rdquo; formed inside the composite particles, which is the apparent manifestation of the diffusion of volatile gases. This study provides theoretical support for the application of multiscale composite particle inhibition of odor-release technology in industrial production

Preparation of Lightweight Ceramsite from Solid Waste Using SiC as a Foaming Agent

SiC was chosen as the foaming agent, and river bottom silt, waste oil sludge, paint bucket slag, and fly ash were used as raw materials, to prepare lightweight ceramsite without adding any chemical additives. The effects of SiC dosing and sintering temperature on various properties of the ceramsite were studied, and the pore-forming mechanism of the lightweight ceramsite was clarified by thermal analysis and X-ray diffraction analysis. The results showed that the single ceramsite compressive strength, water absorption, bulk density, and porosity of ceramsite sintered at 1180 °C with 1.0% SiC were 2.15 MPa, 2.02%, 490 kg/m3, and 23.85%, respectively. The major mineralogical compositions were quartz, fayalite, and kyanite, with small amounts of albite-low from 1140 to 1190 °C. Furthermore, the concentration of all tested heavy metals from ceramsite was lower than the maximum allowable concentration of the leaching solution specified in the Chinese national standard (GB 5085.3-2007), which reveals that this solid waste ceramsite will not cause secondary environmental pollution. The prepared ceramsite, exhibiting lower bulk density, high water absorption and porosity, and effective solidification of deleterious elements, can be used to prepare green lightweight aggregate concrete. Importantly, preparation of solid waste ceramsite is an effective way to dispose of hazardous wastes