Ultrasonic characterization and multiscale analysis for the evaluation of dental implant stability: a sensitivity study Biomedical Signal Processing and Control 42 (2018) 37-44

International audienceWith the aim of surgical success, the evaluation of dental implant long-term stability is an important task for dentists. About that, the complexity of the newly formed bone and the complex boundary conditions at the bone-implant interface induce the main difficulties. In this context, for the quantitative evaluation of primary and secondary stabilities of dental implants, ultrasound based techniques have already been proven to be effective. The microstructure, the mechanical properties and the geometry of the bone-implant system affect the ultrasonic response. The aim of this work is to extract relevant information about primary stability from the complex ultrasonic signal obtained from a probe screwed to the implant. To do this, signal processing based on multiscale analysis has been used. The comparison between experimental and numerical results has been carried out, and a correlation has been observed between the multifractal signature and the stability. Furthermore, a sensitivity study has shown that the variation of certain parameters (i.e. central frequency and trabecular bone density) does not lead to a change in the response

Caractérisation de la Réponse Ultrasonore d'Implant Dentaire : Simulation Numérique et Analyse des Signaux

International audienceThe long-term success of a dental implant is related to the properties of the bone-implant interface. It is important to follow the evolution of bone remodeling phenomena around the implant. To date, there is no satisfactory method for tracking physiological and mechanical properties of this area, and it is difficult for clinicians to qualitatively and quantitatively assess the stability of a dental implant. In this context, methods based on ultrasound wave propagation were already successfully used by our group, in the qualitative and quantitative evaluation of primary and secondary stability of dental implants. In this study we perform numerical simulations, using the finite element method, of wave propagation in a dental implant inserted into bone. To simplify the calculations, an axisymmetric geometry is considered. Given the importance of monitoring of peri-prosthetic area, particular attention is given to the boundary conditions between the implant and the bone. The numerical results are compared with those from experimental tests. These results, numerical and experimental, are then analysed with signal processing tools based on multifractal methods. Analysis of the first results shows that these methods are potentially efficient in this case because they can explore and exploit the multi-scale structure of the signal

Characteristics and outcome of patients with low-/intermediate-risk acute promyelocytic leukemia treated with arsenic trioxide - an international collaborative study

The aim of this study was to characterize a large series of 154 patients with acute promyelocytic leukemia (APL; median age, 53 years; range, 18-90 years) and evaluate real-life outcome after up-front treatment with arsenic trioxide (ATO) and alltrans retinoic acid (ATRA). All patients were included in the prospective NAPOLEON registry (NCT02192619) between 2013 and 2019. APL was de novo in 91% (n=140) and therapy-related in 9% (n=14); 13% (n=20) were older than 70 years. At diagnosis bleeding/hemorrhage was present in 38% and thrombosis in 3%. Complete remission was achieved in 152 patients (99%), whereas two patients (1%) experienced induction death within 18 days after start of therapy. With a median follow-up of 1.99 years (95%-CI, 1.61-2.30 years) 1-year and 2-years overall survival (OS) rates were 97% (95%-CI, 94-100%) and 95% (95%-CI, 91-99%), respectively. Age above 70 years was associated with a significantly shorter OS (P<0.001) as compared to younger patients. So far no relapses were observed. Six patients (4%) died in CR after in median 0.95 years after diagnosis (range, 0.18-2.38 years). Our data confirm the efficiency and durability of ATO/ATRA in the primary management of adult low-/ intermediate-risk APL patients in the real life setting, irrespective of age

Multimodal assesment of the biomechanical properties of the bone-implant interface

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