Efficient calculation of local dose distribution for response modelling in proton and ion beams

We present an algorithm for fast and accurate computation of the local dose distribution in MeV beams of protons, carbon ions or other heavy-charged particles. It uses compound Poisson-process modelling of track interaction and succesive convolutions for fast computation. It can handle mixed particle fields over a wide range of fluences. Since the local dose distribution is the essential part of several approaches to model detector efficiency or cellular response it has potential use in ion-beam dosimetry and radiotherapy.Comment: 9 pages, 3 figure

The Ah receptor: adaptive metabolism, ligand diversity, and the xenokine model

Author Posting. © American Chemical Society, 2020. This is an open access article published under an ACS AuthorChoice License. The definitive version was published in Chemical Research in Toxicology, 33(4), (2020): 860-879, doi:10.1021/acs.chemrestox.9b00476.The Ah receptor (AHR) has been studied for almost five decades. Yet, we still have many important questions about its role in normal physiology and development. Moreover, we still do not fully understand how this protein mediates the adverse effects of a variety of environmental pollutants, such as the polycyclic aromatic hydrocarbons (PAHs), the chlorinated dibenzo-p-dioxins (“dioxins”), and many polyhalogenated biphenyls. To provide a platform for future research, we provide the historical underpinnings of our current state of knowledge about AHR signal transduction, identify a few areas of needed research, and then develop concepts such as adaptive metabolism, ligand structural diversity, and the importance of proligands in receptor activation. We finish with a discussion of the cognate physiological role of the AHR, our perspective on why this receptor is so highly conserved, and how we might think about its cognate ligands in the future.This review is dedicated in memory of the career of Alan Poland, one of the truly great minds in pharmacology and toxicology. This work was supported by the National Institutes of Health Grants R35-ES028377, T32-ES007015, P30-CA014520, P42-ES007381, and U01-ES1026127, The UW SciMed GRS Program, and The Morgridge Foundation. The authors would like to thank Catherine Stanley of UW Media Solutions for her artwork

Correlation of the Havemeyer endoscopic laryngeal grading system with histopathological changes in equine Cricoarytenoideus dorsalis muscles

The establishment of a single validated endoscopic laryngeal grading system for assessing recurrent laryngeal neuropathy (RLN) is desirable to facilitate direct comparisons between the findings of different clinical and research groups worldwide. The objective of this study was to assess the relationship between the Havemeyer endoscopic laryngeal grading system and histopathological changes consistent with RLN in the left cricoarytenoideus dorsalis (CAD) muscle of horses of different breeds with a full range of clinical severities of RLN, i.e., from normal endoscopic laryngeal function to complete laryngeal hemiplegia. Endoscopic grading of laryngeal function of 22 horses was performed using the Havemeyer endoscopic laryngeal grading system. A biopsy sample of the left CAD muscle was obtained from each horse, either at post mortem examination (n = 16), or during routine laryngoplasty surgery (n = 6). A semi-quantitative histopathological scoring system was used to grade the severity of histopathological lesions consistent with RLN in the left CAD muscle of each horse. A significant positive correlation (rs = 0.705, p < 0.001) was found between the Havemeyer grades and sub-grades of laryngeal function and the semi-quantitative assessment of histopathological lesions consistent with RLN in the left CAD muscle. However, a wide spread of muscle histopathological scores was obtained, particularly from horses with Havemeyer sub-grades II.1, III.1 and III.2. In conclusion, the Havemeyer endoscopic laryngeal grading system was found to broadly correlate with histopathological changes consistent with RLN in equine cricoarytenoideus dorsalis muscle

Free Unstable Modes and Massive Bodies in Saturn's Outer B Ring

Voyager images and Cassini occultation data have previously shown that the behavior of the outer edge of Saturn's massive B ring is determined only in part by a static response to the 2:1 inner Lindblad resonance with Mimas. In Cassini images of this region, we find, in addition to the expected wavenumber-2 forced distortion, evidence for unforced self-excited wavenumber-3, wavenumber-2, and wavenumber-1 normal modes. These are the first observations to suggest substantial wave amplification in Saturn's broad rings. Moreover, the presence of these free modes strongly implicates viscous overstability as their underlying cause and, by inference, the cause for most if not all of the unforced structures throughout the high-mass-density B ring and in other high-mass-density regions in Saturn's rings. Analysis of each of the inferred waves reveals a consistent lower bound on the average surface mass density of ~ 44 g/cm^2 for the outer 250 km of the ring, though the true surface density could be as high as 100 g/cm^2 or higher. Interference between the forced and free wavenumber-2 modes yields a total wavenumber-2 pattern that varies in amplitude and orientation with a characteristic period of ~ 5.5 years. We also find localized disturbances, including 3.5-km-tall vertical structures, that provide circumstantial evidence for embedded massive bodies in the Mimas resonance zone. The presence of such bodies is supported by the presence of a shadow-casting moonlet ~ 0.3 km wide near the ring's edge.Comment: 38 pages, 6 figure

Path integral formulation of Hodge duality on the brane

In the warped compactification with a single Randall-Sundrum brane, a puzzling claim has been made that scalar fields can be bound to the brane but their Hodge dual higher-rank anti-symmetric tensors cannot. By explicitly requiring the Hodge duality, a prescription to resolve this puzzle was recently proposed by Duff and Liu. In this note, we implement the Hodge duality via path integral formulation in the presence of the background gravity fields of warped compactifications. It is shown that the prescription of Duff and Liu can be naturally understood within this framework.Comment: 7 pages, LaTe

Parameter-Independent Strategies for pMDPs via POMDPs

Markov Decision Processes (MDPs) are a popular class of models suitable for solving control decision problems in probabilistic reactive systems. We consider parametric MDPs (pMDPs) that include parameters in some of the transition probabilities to account for stochastic uncertainties of the environment such as noise or input disturbances. We study pMDPs with reachability objectives where the parameter values are unknown and impossible to measure directly during execution, but there is a probability distribution known over the parameter values. We study for the first time computing parameter-independent strategies that are expectation optimal, i.e., optimize the expected reachability probability under the probability distribution over the parameters. We present an encoding of our problem to partially observable MDPs (POMDPs), i.e., a reduction of our problem to computing optimal strategies in POMDPs. We evaluate our method experimentally on several benchmarks: a motivating (repeated) learner model; a series of benchmarks of varying configurations of a robot moving on a grid; and a consensus protocol.Comment: Extended version of a QEST 2018 pape

Restricted random walk model as a new testing ground for the applicability of q-statistics

We present exact results obtained from Master Equations for the probability function P(y,T) of sums $y=\sum_{t=1}^T x_t$ of the positions x_t of a discrete random walker restricted to the set of integers between -L and L. We study the asymptotic properties for large values of L and T. For a set of position dependent transition probabilities the functional form of P(y,T) is with very high precision represented by q-Gaussians when T assumes a certain value $T^*\propto L^2$. The domain of y values for which the q-Gaussian apply diverges with L. The fit to a q-Gaussian remains of very high quality even when the exponent $a$ of the transition probability g(x)=|x/L|^a+p with 0<p<<1 is different from 1, all though weak, but essential, deviation from the q-Gaussian does occur for $a\neq1$. To assess the role of correlations we compare the T dependence of P(y,T) for the restricted random walker case with the equivalent dependence for a sum y of uncorrelated variables x each distributed according to 1/g(x).Comment: 5 pages, 7 figs, EPL (2011), in pres

A probabilistic analysis of argument cogency

This paper offers a probabilistic treatment of the conditions for argument cogency as endorsed in informal logic: acceptability, relevance, and sufficiency. Treating a natural language argument as a reason-claim-complex, our analysis identifies content features of defeasible argument on which the RSA conditions depend, namely: change in the commitment to the reason, the reason’s sensitivity and selectivity to the claim, one’s prior commitment to the claim, and the contextually determined thresholds of acceptability for reasons and for claims. Results contrast with, and may indeed serve to correct, the informal understanding and applications of the RSA criteria concerning their conceptual dependence, their function as update-thresholds, and their status as obligatory rather than permissive norms, but also show how these formal and informal normative approachs can in fact align