Frequency of Modifiable Risk Factors in Ischemic Stroke Patients at a Tertiary Care Hospital in Lahore Pakistan

Objective: The objective was to find out the frequency of modifiable risk factors among patients of ischemic stroke at a tertiary care hospital in Lahore Pakistan. Study type,settings& duration:This observational cross-sectional study was conducted at Medical Department Services Hospital, Services Institute of Medical Sciences, Lahore Pakistan from January 2019 to January 2020. Methodology:After an informed consent 105 patients with ischemic stroke aged between 18-65 years from both sex wasincluded in this study. Patients with trauma, tumor, arteriovenousmalformations, unstable cardiopulmonary condition, psychiatric disease and hemorrhagic stroke were excluded. Demographic information and detailed history with physical examination was noted. Blood pressure and sugar levels were measured for all patients. All bloods test including fasting lipid profile were determined. SPSS version 17.0 was used for data analysis. Results:A total of 105 patients of ischemic stroke were enrolled in the present study. Mean age of the patients was 51.2±8.4 years and 73 (69.5%) were male. Mean BMI was 29.3±2.9 kg/m2. Hyperlipidemia was the most frequent risk factor seen in 53 (50.5%) patients with ischemic stroke followed by obesity in 48 (45.8%) patients, smoking in 43 (40.9%), hypertension in 41 (39.1%) and diabetes mellitus in 41 (39.1%) patients. Conclusion:Hyperlipidemia was the leading risk factor in ischemic stroke patients in the present study followed by obesity, smoking, diabetes mellitus and hypertension respectively

Antibiotic Drug Resistance Pattern of Uropathogens in Pediatric Patients in Pakistani Population

The common prevalent diseases in the age of 0 to 6 are related to urinary tract infections. If not properly diagnosed, they will lead to urological and nephrological complications. Uropathogens are developing resistance against most drugs and are harder to treat. A study was done on the inpatients and outpatients of the two hospitals located in Lahore. A total of 39,750 samples that were both male and female were collected. Escherichia and Klebsiella were found in 234 samples based on biochemical characterization, growth on CLED agar, and white blood cell/pus cell (WBC) microscopy. In comparison to males, female samples had a higher number of uropathogens (1:1.29). From the samples of Shaikh Zayed Hospital (SZH), the ratio of Klebsiella to Escherichia (1:1.93) was reported, while this ratio was 1.84:1 from the Children Hospital (CH). The incidence of UTI was higher in the month of September. Randomly selected Escherichia and Klebsiella were verified via a 16S rRNA sequence. Antibiotic resistance profiling of isolated bacterial strains was done against 23 antibiotics. The most efficient antibiotics against Klebsiella and Escherichia were colistin sulphate (100% sensitivity against bacteria from CH; 99.3% against strains from SZH) and polymyxin B (100% sensitivity against strains from SZH; 98.8% against strains from CH). Sensitivity of the total tested strains against meropenem (74%, SZH; 70% CH), Fosfomycin (68%, SZH; 73% CH strains), amikacin (74% SZH; 55% CH), and nitrofurantoin (71% SZH;67% CH) was found, Amoxicillin, ampicillin, and cefuroxime showed 100 to ≥90% resistance and are the least effective