Role of Copper in the Onset of Alzheimer’s Disease Compared to Other Metals

Alzheimer’s disease (AD) is a neurodegenerative disorder that is characterized by amyloid plaques in patients’ brain tissue. The plaques are mainly made of β-amyloid peptides and trace elements including Zn2+, Cu2+, and Fe2+. Some studies have shown that AD can be considered a type of metal dyshomeostasis. Among metal ions involved in plaques, numerous studies have focused on copper ions, which seem to be one of the main cationic elements in plaque formation. The involvement of copper in AD is controversial, as some studies show a copper deficiency in AD, and consequently a need to enhance copper levels, while other data point to copper overload and therefore a need to reduce copper levels. In this paper, the role of copper ions in AD and some contradictory reports are reviewed and discussed

Temperature-induced folding changes of beta-lactoglobulin in hydro-methanolic solutions

International audienc

Novel possibilities of processing of beta-casein with engineered trypsin

International audienc

Impact of mild and acceptable dairy protein modifications on their functional properties and hydrolytic processing

International audienc

Binding of retinoids and beta-carotene to beta-lactoglobulin

International audienc

Ingénierie des protéines alimentaires

National audienc

Binding affinities of beta-ionone and related flavor compounds to beta-lactoglobuline : effects of chemical modifications

28 ref.International audienc

Binding of retinoids and beta-carotene to beta-lactoglobulin

National audienc

La beta-lactoglobuline : une proteine du lait aux multiples facettes

National audienc

Alcohol-induced changes of beta-lactoglobulin-retinol-binding stoichiometry

41 ref.International audienc