Impact of Gene-Gender Effects of Adrenergic Polymorphisms on Hypothalamic-Pituitary-Adrenal Axis Activity in Depressed Patients

Objective: There is overwhelming evidence that activation of the hypothalamic-pituitary-adrenal (HPA) system plays a major role in depression and cardiovascular disease in genetically susceptible individuals. We hypothesized that due to the multiple interactions between the sympathetic and the HPA systems via adrenoceptors, polymorphisms in these genes could have an impact on HPA axis activity in major depression. Methods: Using the dexamethasone/corticotrophin-releasing hormone (DEX/CRH) test, we investigated the association of alpha 2-adrenoceptor (ADRA2A -1291C -> G) and the beta 2-adrenoceptor gene (ADRB2 Arg16Gly) in 189 patients with major depression during the acute state of the disease and after remission. Results: Male ADRA2A -1291G allele homozygotes showed significant pretreatment HPA axis hyperactivity, with increased adrenocorticotropin (ACTH; F = 4.9, d.f. = 2, p = 0.009) and cortisol responses (F = 6.4, d.f. = 2, p = 0.003). In contrast, female ADRB2 Arg/Arg homozygotes had increased pretreatment ACTH (F = 7.17, d.f. = 2, p = 0.001) and cortisol (F = 8.95, d.f. = 2, p = 0.000) levels. Interestingly, in the respective genotypes, the stress hormones remained elevated in the second DEX/CRH test, despite a reduction in depressive symptoms. Conclusions: This study provides evidence that, depending on gender and polymorphisms, there is continuous HPA axis overdrive in a proportion of patients irrespective of the status of depression. Considering the importance of stress hormones for cardiovascular disorders, our data might suggest that these patients are at high risk of comorbidity between depression and cardiovascular disorders. Copyright (c) 2008 S. Karger AG, Base

Dwarf Nova Oscillations and Quasi-Periodic Oscillations in Cataclysmic Variables: III. A New Kind of Dwarf Nova Oscillation, and Further Examples of the Similarities to X-Ray Binaries

We present measurements of the periods of Dwarf Nova Oscillations (DNOs) and Quasi-Periodic Oscillations (QPOs) in Cataclysmic Variable stars (CVs), many culled from published literature, but also others newly observed (in VZ Pyx, CR Boo, OY Car, Z Cha, AQ Eri, TU Men, HX Peg, CN Ori, V893 Sco, WX Hyi and EC2117-54). These provide data for 26 systems. We show that in general P_QPO ~ 15 P_DNO and that the correlation for CVs extends by three orders of magnitude lower in frequency the similar relationship found for X-Ray binaries. In addition, we have found that there is a second type of DNO, previously overlooked, which have periods ~ 4 times those of the regular DNOs (As well as those mined from publications, we have observed them in VW Hyi, OY Car, AQ Eri, V803 Cen, CR Boo, VZ Pyx, HX Peg and EC2117-54). Often both types of DNO coexist. Unlike the standard DNOs, the periods of the new type, which we refer to as longer period DNOs (lpDNOs), are relatively insensitive to accretion luminosity and can even appear in quiescence of dwarf novae. We interpret them as magnetically channelled accretion onto the differentially rotating main body of the white dwarf primary, rather than onto a rapidly slipping equatorial belt as in the case of the standard DNOs. This is supported by published measurements of v sin(i) for some of the primaries. Some similarities of the DNOs, lpDNOs and QPOs in CVs to the three types of QPO in X-Ray binaries (burst pulsation, high and low frequency QPOs) are noted.Comment: 19 pages, 30 figures. To appear in MNRA

Interparticle interactions:Energy potentials, energy transfer, and nanoscale mechanical motion in response to optical radiation

In the interactions between particles of material with slightly different electronic levels, unusually large shifts in the pair potential can result from photoexcitation, and on subsequent electronic excitation transfer. To elicit these phenomena, it is necessary to understand the fundamental differences between a variety of optical properties deriving from dispersion interactions, and processes such as resonance energy transfer that occur under laser irradiance. This helps dispel some confusion in the recent literature. By developing and interpreting the theory at a deeper level, one can anticipate that in suitable systems, light absorption and energy transfer will be accompanied by significant displacements in interparticle separation, leading to nanoscale mechanical motion

DE Canum Venaticorum : a bright, eclipsing red dwarf–white dwarf binary

Context. Close white dwarf–red dwarf binaries must have gone through a common-envelope phase during their evolution. DE CVn is a detached white dwarf–red dwarf binary with a relatively short (∼8.7 h) orbital period. Its brightness and the presence of eclipses makes this system ideal for a more detailed study. Aims. From a study of photometric and spectroscopic observations of DE CVn we derive the system parameters that we discuss in the framework of common-envelope evolution. Methods. Photometric observations of the eclipses are used to determine an accurate ephemeris. From a model fit to an average lowresolution spectrum of DE CVn, we constrain the temperature of the white dwarf and the spectral type of the red dwarf. The eclipse light curve is analysed and combined with the radial velocity curve of the red dwarf determined from time-resolved spectroscopy to derive constraints on the inclination and the masses of the components in the system. Results. The derived ephemeris is HJDmin = 2 452 784.5533(1) + 0.3641394(2) × E. The red dwarf in DE CVn has a spectral type of M3V and the white dwarf has an effective temperature of 8 000 K. The inclination of the system is 86+3◦ −2 and the mass and radius of the red dwarf are 0.41 ± 0.06 M and 0.37+0.06 −0.007 R, respectively, and the mass and radius of the white dwarf are 0.51+0.06 −0.02 M and 0.0136+0.0008 −0.0002 R, respectively. Conclusions. We found that the white dwarf has a hydrogen-rich atmosphere (DA-type). Given that DE CVn has experienced a common-envelope phase, we can reconstruct its evolution and we find that the progenitor of the white dwarf was a relatively lowmass star (M ≤ 1.6 M). The current age of this system is 3.3−7.3 × 109 years, while it will take longer than the Hubble time for DE CVn to evolve into a semi-detached system

Distance to the RR Lyrae Star V716 Monocerotis

We present high quality BVRI CCD photometry of the variable star V716 Monocerotis (= NSV 03775). We confirm it to be an RR Lyrae star of variability type ab (i.e. a fundamental mode pulsator), and determine its metallicity ([Fe/H] = -1.33 +/- 0.25), luminosity (Mv = 0.80 +/- 0.06), and foreground reddening (E(B-V) = 0.05-0.17) from the Fourier components of its light curve. These parameters indicate a distance of 4.1 +/- 0.3 kpc, placing V716 Mon near the plane of the Galaxy well outside the solar circle. This research was conducted as part of the 1999 Research Experiences for Undergraduates (REU) and Practicas de Investigacion en Astronomia (PIA) Programs at Cerro Tololo Inter-American Observatory (CTIO).Comment: 9 pages including 2 figures and 2 tables; accepted by PAS

Swift J1753.5-0127: The Black Hole Candidate with the shortest orbital period

We present time-resolved photometry of the optical counterpart to the black hole candidate Swift J1753.5-0127, which has remained in the low/hard X-ray state and bright at optical/IR wavelengths since its discovery in 2005. At the time of our observations Swift J1753.5-0127 does not show a decay trend but remains stable at R=16.45 with a night to night variability of ~0.05 mag. The R-band light curves, taken from 2007 June 3 to August 31, are not sinusoidal, but exhibit a complex morphology with remarkable changes in shape and amplitude. The best period determination is 3.2443+-0.0010 hours. This photometric period is likely a superhump period, slightly larger than the orbital period. Therefore, Swift J1753.5-0127 is the black hole candidate with the shortest orbital period observed to date. Our estimation of the distance is comparable to values previously published and likely places Swift J1753.5-0127 in the Galactic halo.Comment: Accepted for publication in Ap

Sensitivity of a tonne-scale NEXT detector for neutrinoless double beta decay searches

The Neutrino Experiment with a Xenon TPC (NEXT) searches for the neutrinoless double-beta decay of Xe-136 using high-pressure xenon gas TPCs with electroluminescent amplification. A scaled-up version of this technology with about 1 tonne of enriched xenon could reach in less than 5 years of operation a sensitivity to the half-life of neutrinoless double-beta decay decay better than 1E27 years, improving the current limits by at least one order of magnitude. This prediction is based on a well-understood background model dominated by radiogenic sources. The detector concept presented here represents a first step on a compelling path towards sensitivity to the parameter space defined by the inverted ordering of neutrino masses, and beyond.Comment: 22 pages, 11 figure

Catalog of Galactic Beta Cephei Stars

We present an extensive and up-to-date catalog of Galactic Beta Cephei stars. This catalog is intended to give a comprehensive overview of observational characteristics of all known Beta Cephei stars. 93 stars could be confirmed to be Beta Cephei stars. For some stars we re-analyzed published data or conducted our own analyses. 61 stars were rejected from the final Beta Cephei list, and 77 stars are suspected to be Beta Cephei stars. A list of critically selected pulsation frequencies for confirmed Beta Cephei stars is also presented. We analyze the Beta Cephei stars as a group, such as the distributions of their spectral types, projected rotational velocities, radial velocities, pulsation periods, and Galactic coordinates. We confirm that the majority of these stars are multiperiodic pulsators. We show that, besides two exceptions, the Beta Cephei stars with high pulsation amplitudes are slow rotators. We construct a theoretical HR diagram that suggests that almost all 93 Beta Cephei stars are MS objects. We discuss the observational boundaries of Beta Cephei pulsation and their physical parameters. We corroborate that the excited pulsation modes are near to the radial fundamental mode in frequency and we show that the mass distribution of the stars peaks at 12 solar masses. We point out that the theoretical instability strip of the Beta Cephei stars is filled neither at the cool nor at the hot end and attempt to explain this observation