Fimasartan versus perindopril with and without diuretics in the treatment of elderly patients with essential hypertension (Fimasartan in the Senior Subjects (FITNESS)): study protocol for a randomized controlled trial

Background Hypertension is an important risk factor for cardiovascular disease, even in the elderly. Fimasartan is a new non-peptide angiotensin II receptor blocker with a selective type I receptor blocking effect. The objective of this study is to confirm the safety and the non-inferiority of the blood pressure–lowering effect of fimasartan compared with those of perindopril, which has been proven safe and effective in elderly patients with hypertension. Methods This is a randomized, double-blind, active-controlled, two-parallel group, optional-titration, multicenter, phase 3 study comparing the efficacy and safety of fimasartan and perindopril arginine. The study population consists of individuals 70 years old or older with essential hypertension. The primary outcome will be a change in sitting systolic blood pressure from baseline after the administration of the investigational product for 8 weeks. The secondary outcomes will be a change in sitting diastolic blood pressure from baseline and changes in sitting systolic blood pressure and diastolic blood pressure from baseline after the administration of the investigational product for 4, 16, and 24 weeks. The sample size will be 119 subjects for each group to confer enough power to test for the primary outcome. Discussion Research to confirm the efficacy and safety of a new medicine compared with those of previously proven anti-hypertensive drugs is beneficial to guide physicians in the selection of therapeutic agents. If it is confirmed that the new drug is not inferior to the existing drug, the drug will be considered as an option in the treatment of hypertension in elderly patients. Trial registration ClinicalTrials.gov Identifier: NCT03246555, registered on July 25, 2017.The study is funded by Boryung Pharmaceutical Co., Ltd. The company was involved in all stages of the study conduct and design. Boryung also took responsibility for all costs associated with the development and publishing of the manuscript

Former les managers publics, placés sous le « regard de l'autre », à faire face courageusement : le cas des administrateurs territoriaux

International audienceIn socio-economic and political evolutions since the 1980s, local authorities tested some private management tools within their organization. Aware of the managerial challenge, they also change the concept of recruitment, training and management of their public managers following two main axes : the commitment towards local public interest and practice learning by experiences. Our empirical study on 1125 public local managers (in collaboration with the Association of Public Local Managers) shows that this changing has given positive effects.Face aux évolutions socio-économique et politique depuis les années 1980, les collectivités territoriales ont procédé aux expérimentations de certains outils de gestion du privé en leur sein. Conscientes de l’enjeu managérial, elles ont fait également évoluer le concept du recrutement, de la formation et de la gestion de leurs managers publics autour de deux axes principaux : l’engagement envers l’intérêt public local et l’apprentissage pratique par expériences. Notre étude empirique sur 1 125 administrateurs territoriaux (en collaboration avec l’Association des Administrateurs Territoriaux de France) montre que cette évolution a porté ses fruits

Au-delà du New Public Management : cas de la gestion des administrateurs territoriaux dans les collectivités territoriales

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Les regards sur l’administration publique réformée

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Hybridation du New Public Management : cas de gestion des administrateurs territoriaux en France

International audience“How to diffuse the New Public Management in the public administration and continue to accomplish public service missions ?”. The France answered with hybridization (Boyer, 1997). Our empirical study of 1,125 local authorities’ managers (in cooperation with the French Association des Adminsitrateurs Territoriaux) shows that hybrid management is a perfect example.Face à la question de savoir « comment diffuser le New Public Management dans l’administration publique et continuer à accomplir les missions de service public », la France a trouvé ses réponses dans l’hybridation (Boyer, 1997). Notre étude empirique sur 1 125 administrateurs territoriaux (en collaboration avec l’Association des Administrateurs Territoriaux de France) montre que la gestion hybride en est une parfaite illustration

후기신공공관리(Post-NPM)와 관료제 :프랑스 지방행정관의 인사관리전략 연구

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한국인 해외학자가 진단,평가하는 국가경쟁력 : 한국의 지속개발에 필요한 여성인력 자원: 프랑스 경우

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Raréfaction des ressources publiques et recherche de performance : vers de nouvelles formes organisationnelles dans les collectivités territoriales ?

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Fonctionnaires, tous (dé)professionnalisés ? Étude de cas sur les Comptables Publics des établissements publics

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Fonctionnaires, tous (dé)professionnalisés ? Étude de cas sur les Comptables Publics des établissements publics

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