Polymorphic form II of 4,4′-methyl­enebis(benzene­sulfonamide)

In the title compound, C13H14N2O4S2 (alternative names: diphenyl­methane-4,4′-disulfonamide, nirexon, CRN: 535–66-0), the two benzene rings form a dihedral angle of 70.8 (1)°. There are two sets of shorter (H⋯O < 2.1 Å) and longer (H⋯O > 2.4 Å) N—H⋯O hydrogen bonds per sulfonamide NH2 group, which together result in hydrogen-bonded sheets parallel (102). Adjacent sheets are connected to one another by an additional N—H⋯N inter­action so that a three-dimensional network of hydrogen-bonded mol­ecules is formed. The investigated polymorph is identical with the form II previously described by Kuhnert-Brandstätter & Moser [(1981). Mikrochim. Acta, 75, 421–440]

Effect of pulsed methylprednisolone on pain, in patients with HTLV-1-associated myelopathy

HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is an immune mediated myelopathy caused by the human T-lymphotropic virus type 1 (HTLV-1). The efficacy of treatments used for patients with HAM/TSP is uncertain. The aim of this study is to document the efficacy of pulsed methylprednisolone in patients with HAM/TSP. Data from an open cohort of 26 patients with HAM/TSP was retrospectively analysed. 1g IV methylprednisolone was infused on three consecutive days. The outcomes were pain, gait, urinary frequency and nocturia, a range of inflammatory markers and HTLV-1 proviral load. Treatment was well tolerated in all but one patient. Significant improvements in pain were: observed immediately, unrelated to duration of disease and maintained for three months. Improvement in gait was only seen on Day 3 of treatment. Baseline cytokine concentrations did not correlate to baseline pain or gait impairment but a decrease in tumour necrosis factor-alpha (TNF-α) concentration after pulsed methylprednisolone was associated with improvements in both. Until compared with placebo, treatment with pulsed methylprednisolone should be offered to patients with HAM/TSP for the treatment of pain present despite regular analgesia

Gliquidone

The title compound {systematic name: N-cyclo­hexyl­carba­moyl-4-[2-(7-meth­oxy-4,4-dimethyl-1,3-dioxo-1,2,3,4-tetra­hydro­isoquinolin-2-yl)eth­yl]benzene­sulfonamide}, C27H33N3O6S, displays an intra­molecular N—H⋯O=S inter­action, as well as inter­molecular N—H⋯O=C hydrogen bonds. The latter inter­actions lead to the formation of hydrogen-bonded chains parallel to the c axis. The conformation of the sulfonyl­urea fragment is in agreement with a recent theoretical study [Kasetti et al. (2010 ▶). J. Phys. Chem. B, 114, 11603–11610]

Space-times which are asymptotic to certain Friedman-Robertson-Walker space-times at timelike infinity

We define space-times which are asymptotic to radiation dominant Friedman-Robertson-Walker space-times at timelike infinity and study the asymptotic structure. We discuss the local asymptotic symmetry and give a definition of the total energy from the electric part of the Weyl tensor.Comment: 8 pages, Revte