Noninfectious causes of diffuse pulmonary infiltrations in chronic renal failure: metastatic pulmonary calsification

Metastatic pulmonary calsification (MPC) is a metabolic lung disease characterized by the deposition of calcium in pulmonaryparenchyma. It may occur due to many bening or malign pathologies. Especially it is most commonly seen in patients with endstage chronic renal failure received renal replacement treatment. The case we report here involved a history of renal transplantationabout 22 months ago. His thorax computed tomography had demonstrated bilateral disseminated infiltrations with ground-glass densities predominantly in the upper lobes and it was seen partially preserved subpleural areas and basal zones. Thehistopathological results in transbronchial lung biopsy indicated metastatic pulmonary calsification. We wanted to discuss patientwith the accompaniment of literature

Prevalence and clinical significance of a patent foramen ovale in patients with chronic obstructive pulmonary disease

SummaryBackgroundA patent foramen ovale (PFO) is not widely recognized as a factor contributing to hypoxemia in patients with chronic obstructive pulmonary disease (COPD). We therefore sought to clarify the prevalence and clinical significance of a PFO in patients with COPD, and to analyze the factors related to its occurrence.MethodsThis study included 52 consecutive stable patients with COPD and 50 healthy controls. The demographic and clinical features of the study group were noted. To test for a PFO, standard and contrast transthoracic echocardiographic examinations were performed while resting and during the Valsalva maneuver (VM). Patients performed 6-min walking tests (6 MWT), and the distances traveled were measured.ResultsDuring VM, we detected a PFO in 23 COPD patients and 10 healthy controls (P<0.01). A PFO was detected while resting in 11 COPD patients, but in none of the controls (P=0.001). Comparison of multiple parameters between COPD patients with and without a PFO during VM did not reveal any clinically significant differences. When we compared COPD patients with and without a PFO during resting, however, we found that the former had longer durations of disease, lower PaO2 and SaO2, higher dyspnea scores, shorter distances walked during 6 MWT and higher desaturation rates (P<0.05). Logistic regression analysis showed that longer duration of disease, lower SaO2 and higher systolic pulmonary artery pressure were independent predictors of the occurrence of a PFO in resting COPD patients.ConclusionsThe prevalence of a PFO is higher in patients with COPD than in healthy individuals. The presence of a PFO while resting may contribute significantly to the deterioration of arterial oxygenation and performance status. These findings indicate that a PFO may be a principle cause of hypoxemia in patients with COPD

The affecting factors and prevalence rate of sick building syndrome in healthcare workers

Sick building syndrome (SBS) is defined as symptoms that occur while living or working in a certain building but disappear after moving away from the environment. In this study, we aimed to determine the effects of indoor air pollutants on the health of employees, the prevalence of SBS in healthcare workers at the university hospital, its relationship with environmental and personal factors and the respiratory system. A questionnaire was applied to 951 healthcare workers who agreed to participate in the study. Having at least one general, one mucosal and one skin symptom every week in the last 3 months was accepted as SBS. Temperature, CO and CO2 levels and relative humidity were measured in different areas of the hospital. The prevalence of SBS was 62.1%. There was a statistically significant relationship between SBS and having a chronic disease (p [Med-Science 2023; 12(1.000): 87-93