Scoliosis : lower limb asymmetries during the gait cycle

This research was presented in the form of a poster presentation at the National Symposium of Health Sciences organised by the University of Malta, on the 24th April 2014.Several studies indicate that the gait pattern of subjects suffering from scoliosis differs from the norm. However, there is conflicting evidence regarding the source of this discrepancy. The objective of this study is to evaluate lower limb asymmetries in selected gait variables. Study design: A case–control study on lower limb asymmetries during gait which can be related to scoliosis. 31 subjects with scoliosis (Study Group - SG) and an equal comparative control sample (Control Group – CG) of subjects underwent objective gait analysis with the Vicon® motion caption system whilst walking at a comfortable speed along the gait laboratory walkway. Analysis was performed at three levels: (1) Asymmetry in the SG against asymmetry in the CG, (2) Difference in magnitude of asymmetry between the SG and CG, and (3) Global mean values in the SG vs. CG. The Paired Student T-Test was used for intra-group analysis whilst the Independent Student T-Test was used for inter-group analysis of the selected parameters, which include temporal parameters (stride length, stride time, step length, individual step speed, speed of gait, cadence, swing-to-stance ratio), ground reaction force (peak GRF values during Loading and Propulsion phases, vertical component only) and electromyography (peak EMG values and their time of onset, as a percentage of the gait cycle) of two lower limb muscles (Gastronemius and Vastus Medialis). No intra-group variation was found to be significant. However, the speed of gait was found to be significantly slower (p = 0.03) in scoliotic subjects when compared to the norm, as a result of the shorter stride length (p = 0.002 and longer stride time (p = 0.001) in the SG. Furthermore, there was statistical significance in the time of onset of EMG peaks for the Lateral Gastrocnemius (p = 0.02) with regards to inter-group difference in magnitude of lower limb asymmetry and global mean values. Scoliosis is a tri-planar deformity which has some impact on the gait pattern. This research study concludes that scoliotic subjects have a slower speed of gait due to a shorter stride length and a longer stride time, together with variations in the timing of muscle activation.peer-reviewe

Parallel Hierarchical Affinity Propagation with MapReduce

The accelerated evolution and explosion of the Internet and social media is generating voluminous quantities of data (on zettabyte scales). Paramount amongst the desires to manipulate and extract actionable intelligence from vast big data volumes is the need for scalable, performance-conscious analytics algorithms. To directly address this need, we propose a novel MapReduce implementation of the exemplar-based clustering algorithm known as Affinity Propagation. Our parallelization strategy extends to the multilevel Hierarchical Affinity Propagation algorithm and enables tiered aggregation of unstructured data with minimal free parameters, in principle requiring only a similarity measure between data points. We detail the linear run-time complexity of our approach, overcoming the limiting quadratic complexity of the original algorithm. Experimental validation of our clustering methodology on a variety of synthetic and real data sets (e.g. images and point data) demonstrates our competitiveness against other state-of-the-art MapReduce clustering techniques

Relativistic mean-field theories for neutron-star physics based on chiral effective field theory

We describe and implement a procedure for determining the couplings of a Relativistic Mean-Field Theory (RMFT) that is optimized for application to neutron star phenomenology. In the standard RMFT approach, the couplings are constrained by comparing the theory's predictions for symmetric matter at saturation density with measured nuclear properties. The theory is then applied to neutron stars which consist of neutron-rich matter at densities ranging up to several times saturation density, which allows for additional astrophysical constraints. In our approach, rather than using the RMFT to extrapolate from symmetric to neutron-rich matter and from finite-sized nuclei to uniform matter, we fit the RMFT to properties of uniform pure neutron matter obtained from chiral effective field theory. Chiral effective field theory incorporates the experimental data for nuclei in the framework of a controlled expansion for nuclear forces valid at nuclear densities and enables us to account for theoretical uncertainties when fitting the RMFT. We construct four simple RMFTs that span the uncertainties provided by chiral effective field theory for neutron matter, and are consistent with current astrophysical constraints on the equation of state. Our RMFTs can be used to model the properties of neutron-rich matter across the vast range of densities and temperatures encountered in neutron stars and their mergers.Comment: V2: Minor corrections, version published in PRC. 12 pages and 5 figure

Tabulated Equations of State From Models Informed by Chiral Effective Field Theory

We construct four equation of state (EoS) tables, tabulated over a range of temperatures, densities, and charge fractions, relevant for neutron star applications such as simulations of neutron star mergers. The EoS are computed from a relativistic mean-field theory constrained by the pure neutron matter EoS from chiral effective field theory, inferred properties of isospin-symmetric nuclear matter, and astrophysical observations of neutron star structure. To model nuclear matter at low densities, we attach an EoS that models inhomogeneous nuclear matter at arbitrary temperatures and charge fractions. The four EoS tables we develop are available from the CompOSE EoS repository compose.obspm.fr/eos/297 and gitlab.com/ahaber/qmc-rmf-tables.Comment: 8 pages, 3 figures v2: version published in Phys. Scr. 98, added finite T chiral EFT compariso

Heavy Sneutrinos as Dark Matter

We calculate the relic density of very heavy, stable scalar neutrinos in the minimal supersymmetric standard model. We include all two-body final states, as well as the effects of co-annihilation with scalar electrons. We find that the sneutrino relic density is in the cosmologically interesting region 0.1\ltwid\Omega_{\sn}h^2\ltwid 1.0 for 550\gev\ltwid\msn\ltwid 2300\gev. For nominal values of the parameters of our galactic halo, recent results from the Heidelberg--Moscow direct detection experiment set an upper limit on \Omega_{\sn} which is lower by a factor ranging from two to ten, depending on \msn.Comment: 7 pages in LaTeX, plus 1 uuencoded figure (uses epsf), UCSBTH--94--29, UMN--TH--1306/9

Petion for a Writ of Certiorari. Knight v. Thompson, 136 S.Ct. 2534 (2016) (No. 15-999), 2016 U.S. S. Ct. Briefs LEXIS 542, 2016 WL 447654

QUESTION PRESENTED In Holt v. Hobbs, 135 S.Ct. 853 (2015), this Court held that the Religious Land Use and Institutionalized Persons Act of 2000 (“RLUIPA”), renders unlawful an absolute ban on inmates\u27 wearing a beard for religious reasons. The Eleventh Circuit, subsequent to and despite this Court\u27s decision in Holt, rejected a RLUIPA challenge to Alabama\u27s similarly inflexible policy prohibiting all male inmates from wearing long hair for religious reasons. A vast majority of states, the District of Columbia, and all federal prisons accommodate inmates whose religious practices include wearing beards or long hair. The Question Presented is: Whether Alabama\u27s grooming policy violates RLUIPA, 42 U.S.C. § 2000cc, et seq., to the extent that it prohibits Petitioners from wearing unshorn hair in accordance with their sincerely held religious beliefs

Reply Brief of Petitioners. Knight v. Thompson, 136 S.Ct. 2534 (2016) (No. 15-999), 2016 U.S. S. Ct. Briefs LEXIS 1645, 2016 WL 1555013+A12

QUESTION PRESENTED Section 3 of the Religious Land Use and Institutionalized Persons Act of 2000 ( RLUIPA ) prohibits state and local governments from imposing a substantial burden on the religious exercise of a person residing in or confined to an institution . . . unless the government demonstrates that imposition of the burden on that person : (1) is in furtherance of a compelling governmental interest, and (2) is the least restrictive means of furthering that compelling governmental interest. 42 U.S.C. § 2000cc-l(a). The Question Presented is: Whether RLUIPA requires that prison officials actually consider and demonstrate a sufficient basis for rejecting widely accepted accommodations to traditional religious practices as part of their burden of proving that they have chosen the least restrictive means of furthering their asserted governmental interests

The hepatic transcriptome in human liver disease

The transcriptome is the mRNA transcript pool in a cell, organ or tissue with the liver transcriptome being amongst the most complex of any organ. Functional genomics methodologies are now being widely utilized to study transcriptomes including the hepatic transcriptome. This review outlines commonly used methods of transcriptome analysis, especially gene array analysis, focusing on publications utilizing these methods to understand human liver disease. Additionally, we have outlined the relationship between transcript and protein expressions as well as summarizing what is known about the variability of the transcriptome in non-diseased liver tissue. The approaches covered include gene array analysis, serial analysis of gene expression, subtractive hybridization and differential display. The discussion focuses on primate whole organ studies and in-vitro cell culture systems utilized. It is now clear that there are a vast number research opportunities for transcriptome analysis of human liver disease as we attempt to better understand both non-diseased and disease hepatic mRNA expression. We conclude that hepatic transcriptome analysis has already made significant contributions to the understanding of human liver pathobiology

Calculations of Neutralino-Stau Coannihilation Channels and the Cosmologically Relevant Region of MSSM Parameter Space

Assuming that the lightest supersymmetric particle (LSP) is the lightest neutralino, we present a detailed exploration of neutralino-stau coannihilation channels, including analytical expressions and numerical results. We also include neutralino coannihilations with the selectron and smuon. We evaluate the implications of coannihilations for the cosmological relic density of the LSP, which is assumed to be stable, in the constrained minimal supersymmetric extension of the Standard Model (CMSSM), in which the soft supersymmetry-breaking parameters are universal at the supergravity GUT scale. We evaluate the changes due to coannihilations in the region of the MSSM parameter space that is consistent with the cosmological upper limit on the relic LSP density. In particular, we find that the upper limit on the mass of the neutralino is increased from about 200 GeV to about 600 GeV in the CMSSM, and estimate a qualitatively similar increase for gauginos in the general MSSM.Comment: 38 pages in LaTeX, including 25 encapsulated postscript figures. Added small clarification in the text, corrected some typos in the appendix. Figures and conclusions unchange