A time-domain method to solve transient elastic wave propagation in a multilayer medium with a hybrid spectral-finite element space approximation

International audienceThis paper introduces a new numerical hybrid method to simulate transient wave propagation in a multilayer semi-infinite medium, which can be fluid or solid, subjected to given transient loads. The medium is constituted of a finite number of unbounded layers with finite thicknesses. The method has a low numerical cost and is relatively straightforward to implement, as opposed to most available numerical techniques devoted to similar problems. The proposed method is based on a time-domain formulation associated with a 2D-space Fourier transform for the variables associated with the two infinite dimensions and uses a finite element approximation in the direction perpendicular to the layers. An illustration of the method is given for an elasto-acoustic wave propagation problem: a three-layer medium constituted of an elastic layer sandwiched between two acoustic fluid layers and excited by an acoustic line source located in one fluid layer

PEG-asparaginase induced severe hypertriglyceridemia

Asparaginase (ASP) is an effective chemotherapy agent extensively used in children with acute lymphocytic leukemia (ALL). There has been a recent interest in using ASP in adults with ALL, particularly the less toxic pegylated (PEG) formulation. Hypertriglyceridemia (HTG) is a rare complication of PEG-ASP therapy. We report two cases of obese patients who developed severe HTG after receiving PEG for ALL. Both patients were incidentally found to have severe HTG (TG of 4,330 and 4,420 mg/dL). In both patients, there was no personal or family history of dyslipidemia or hypothyroidism. There was no evidence of pancreatitis or skin manifestations of HTG. Both patients were treated with PEG cessation, low-fat diet and pharmacotherapy. Both patients were re-challenged with PEG, with subsequent increase in TG but no associated complications. TG returned to baseline after discontinuing PEG and while on therapy for HTG. A literature review of PEG-induced HTG in adults demonstrated similar results: asymptomatic presentation despite very severe HTG. HTG is a rare but clinically important adverse effect of PEG. Underlying obesity and/or diabetes may represent risk factors. Clinicians should monitor TG levels during PEG therapy to avoid TG-induced pancreatitis

Dispersion de vitesse dans l'os trabéculaire : influence de la diffusion indépendante et de l'absorption visqueuse

National audienc

Accounting for multiple scattering allows a better prediction of velocity dispersion in trabecular bone than an independent scattering model.

International audienc

Prediction of 'anomalous' velocity dispersion with an independent scattering model in trabecular bone : comparison with a multiple scattering model

International audienc

Using acoustical modeling and numerical simulation for bone quantitative ultrasound.

International audienc

Anomalous behavior of ultrasonic velocity dispersion in bovine cortical bone

International audienc

Ultrasonic velocity dispersion in bovine cortical bone : an experimental

International audienc

Ultrasonic velocity dispersion in bovine cortical bone.

International audienc

Sensitivity of QUS parameters to controlled variations of bone strength assessed with a cellular model

International audienc