Intragenic L1 Insertion: One Possibility of Brain Disorder

Long interspersed nuclear element 1 (LINE1, L1) is a retrotransposon comprising ~17% of the human genome. A subset of L1s maintains the potential to mobilize and alter the genomic landscape, consequently contributing to the change in genome integrity and gene expression. L1 retrotransposition occurs in the human brain regardless of disease status. However, in the brain of patients with various brain diseases, the expression level and copy number of L1 are significantly increased. In this review, we briefly introduce the methodologies applied to measure L1 mobility and identify genomic loci where new insertion of L1 occurs in the brain. Then, we present a list of genes disrupted by L1 transposition in the genome of patients with brain disorders. Finally, we discuss the association between genes disrupted by L1 and relative brain disorders

Electrochemical production of multicarbon alcohols from CO2 over Cu nanoparticles supported by N-doped porous carbon materials

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1D Modeling Considering Noise and Vibration of Vehicle Window Brushed DC Motor

This study proposes 1D modeling that considers the noise and vibration of a vehicle window-brushed DC motor. The electrical and mechanical components of the brush DC motor are included, creating a model that considers noise and vibration. The model has a back electromagnetic force (EMF) including vibration components and is constructed based on an electric circuit and transfer functions. To ensure the reliability of the model, the back EMF, noise, and vibration experiment environment of the brushed DC motor were configured. The measured back EMF was applied to the model, and it was confirmed that the simulation results of the model were consistent with the measured noise and vibrations

1D Modeling Considering Noise and Vibration of Vehicle Window Brushed DC Motor

This study proposes 1D modeling that considers the noise and vibration of a vehicle window-brushed DC motor. The electrical and mechanical components of the brush DC motor are included, creating a model that considers noise and vibration. The model has a back electromagnetic force (EMF) including vibration components and is constructed based on an electric circuit and transfer functions. To ensure the reliability of the model, the back EMF, noise, and vibration experiment environment of the brushed DC motor were configured. The measured back EMF was applied to the model, and it was confirmed that the simulation results of the model were consistent with the measured noise and vibrations

Synthesis of palladium-antimony alloy nanoparticles on porous carbon materials for the ethanol oxidation reaction

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Surfactant-controlled synthesis of polygonal-stacked Cu2O as advanced anode materials for Li-ion batteries

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Solar-energy driven deposition of tiny rod shaped Sn catalyst for electrochemical CO₂ reduction

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N-doped carbon nanoweb-supported Ni/NiO heterostructure as hybrid catalysts for hydrogen evolution reaction in an alkaline phase

The design of the cost-effective, efficient, and durable electrocatalysts for hydrogen evolution reaction (HER) is of great importance in the field of clean and renewable energies. In this study, Ni/NiO nanocomposite supported on N-doped carbon nanoweb (Ni/NiO/NCW) hybrid materials are proposed as an efficient electrocatalyst for HER in alkaline media. A series of Ni/NiO/NCW hybrid catalysts were prepared via polymerization of polypyrrole (PPy) in the presence of a surfactant, followed by incipient wetness impregnation and heat treatment techniques. The resulting Ni/NiO/NCW hybrid catalysts exhibit an excellent electrocatalytic properties with a lower overpotential of 105.3 mV (vs RHE) at 10 mA cm(-2), a smaller value of Tafel slope (55.2 mV dec(-1)) and almost 100% Faradaic efficiency. It also shows good stability in performance attenuation during continuous cyclic voltammetry sweeps for 1000 cycles. Its excellent electrocatalytic performance for alkaline hydrogen evolution reaction can be attributed to the synergistic effect associated with the morphological benefit of 3D N-doped carbon nanoweb and Ni/NiO heterostructure with the optimal ratio of Ni to NiO. (C) 2020 Elsevier B.V. All rights reserved.11Nsciescopu

Anion defect-engineered amorphous manganese oxide as highly efficient electrocatalysts for CO2 conversion

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Enhanced Therapeutic Effect of Optimized Melittin-dKLA, a Peptide Agent Targeting M2-like Tumor-Associated Macrophages in Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) is characterized by a high possibility of metastasis. M2-like tumor-associated macrophages (TAMs) are the main components of the tumor microenvironment (TME) and play a key role in TNBC metastasis. Therefore, TAMs may be a potential target for reducing TNBC metastasis. Melittin-dKLA, a peptide composed of fused melittin and pro-apoptotic peptide d(KLAKLAK)2 (dKLA), showed a potent therapeutic effect against cancers by depleting TAMs. However, melittin has a strong adverse hemolytic effect. Hence, we attempted to improve the therapeutic potential of melittin-dKLA by reducing toxicity and increasing stability. Nine truncated melittin fragments were synthesized and examined. Of the nine peptides, the melittin-dKLA8-26 showed the best binding properties to M2 macrophages and discriminated M0/M1/M2. All fragments, except melittin, lost their hemolytic effects. To increase the stability of the peptide, melittin-dKLA8-26 fragment was conjugated with PEGylation at the amino terminus and was named PEG-melittin-dKLA8-26. This final drug candidate was assessed in vivo in a murine TNBC model and showed superior effects on tumor growth, survival rates, and lung metastasis compared with the previously used melittin-dKLA. Taken together, our study showed that the novel PEG-melittin-dKLA8-26 possesses potential as a new drug for treating TNBC and TNBC-mediated metastasis by targeting TAMs