Complete gate control of supercurrent in graphene p-n junctions

In a conventional Josephson junction of graphene, the supercurrent is not turned off even at the charge neutrality point, impeding further development of superconducting quantum information devices based on graphene. Here we fabricate bipolar Josephson junctions of graphene, in which a p-n potential barrier is formed in graphene with two closely spaced superconducting contacts, and realize supercurrent ON/OFF states using electrostatic gating only. The bipolar Josephson junctions of graphene also show fully gate-driven macroscopic quantum tunnelling behaviour of Josephson phase particles in a potential well, where the confinement energy is gate tuneable. We suggest that the supercurrent OFF state is mainly caused by a supercurrent dephasing mechanism due to a random pseudomagnetic field generated by ripples in graphene, in sharp contrast to other nanohybrid Josephson junctions. Our study may pave the way for the development of new gate-tuneable superconducting quantum information devices.open114344sciescopu

On the coherency of dynamic load estimates for vehicles on flexible structures

This paper develops a novel form of a well-known signal processing technique, so as to be applicable to the interaction between a heavy truck and a supporting bridge structure. Motivated by the problem of structural health monitoring of bridges, a new modal coherency function is defined. This relates the input action of moving wheel loads to the dynamic response of the bridge, including the effects of unevenness of the road surface and the vertical dynamics of the truck suspension. The analysis here is specifically aimed at future experimental testing – the validation of axle load estimators obtained from sensors on the truck. It is applicable even when no independent ‘ground truth’ for the dynamic loads is available. The approach can be more widely used in the analysis of dynamic interactions involving suspended moving loads on deformable structures, e.g. for structural vibrations due to high-speed train

Heterotopic heart transplantation in the rat receiving FK-506 alone or with cyclosporine.

In rats, FK significantly prolonged heterotopic heart graft survival over a wide dose range when given for 2 weeks starting on the day of the operation. Brief courses of FK for one to four days preoperatively, and especially beginning four days postoperatively, allowed long subsequent survival of heart grafts in otherwise untreated recipients. The seeming acceptance of the grafts with postoperative FK treatment was largely but not exclusively donor specific when tested eight days after the last FK dose by second grafts from the same donor v third-party donor grafts. FK in minimally therapeutic doses was synergistic with suboptimal doses of CyA

Temporal and Spatial Expression Patterns of miR-302 and miR-367 During Early Embryonic Chick Development

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Regulation of T Helper 17 by Bacteria: An Approach for the Treatment of Hepatocellular Carcinoma

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The estrogen-related receptor alpha upregulates secretin expressions in response to hypertonicity and angiotensin II stimulation

Osmoregulation via maintenance of water and salt homeostasis is a vital process. In the brain, a functional secretin (SCT) and secretin receptor (SCTR) axis has recently been shown to mediate central actions of angiotensin II (ANGII), including initiation of water intake and stimulation of vasopressin (VP) expression and release. In this report, we provide evidence that estrogen-related receptor α (ERRα, NR3B1), a transcription factor mainly involved in metabolism, acts as an upstream activator of the SCT gene. In vitro studies using mouse hypothalamic cell line N-42 show that ERRα upregulates SCT promoter and gene expression. More importantly, knockdown of endogenous ERRα abolishes SCT promoter activation in response to hypertonic and ANGII stimulations. In mouse brain, ERRα coexpresses with SCT in various osmoregulatory brain regions, including the lamina terminalis and the paraventricular nucleus of the hypothalamus, and its expression is induced by hyperosmotic and ANGII treatments. Based on our data, we propose that both the upregulation of ERRα and/or the increased binding of ERRα to the mouse SCT promoter are two possible mechanisms for the elevated SCT expression upon hyperosmolality and central ANGII stimulation. © 2012 Lee et al.published_or_final_versio

Distinctive Genetic Activity Pattern of the Human Dental Pulp between Deciduous and Permanent Teeth

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