Generating controllable atom-light entanglement with a Raman atom laser system

We introduce a scheme for creating continuous variable entanglement between an atomic beam and an optical field, by using squeezed light to outcouple atoms from a BEC via a Raman transition. We model the full multimode dynamics of the atom laser beam and the squeezed optical field, and show that with appropriate two-photon detuning and two-photon Rabi frequency, the transmitted light is entangled in amplitude and phase with the outcoupled atom laser beam. The degree of entanglement is controllable via changes in the two-photon Rabi frequency of the outcoupling process.Comment: 4 pages, 4 figure

Different forms of the bovine PrP gene have five or six copies of a short, G-C-rich element within the protein-coding exon

Current models of the virus-like agents of scrapie and bovine spongiform encephalopathy (BSE) have to take into account that structural changes in a host-encoded protein (PrP protein) exhibit an effect on the time course of these diseases and the survival time of any man or animal exposed to these pathogens. We report here the sequence of different forms of the bovine PrP gene which contain either five or six copies of a short, G-C-rich element which encodes the octapeptide Pro-His-Gly-Gly-Gly-Trp-Gly-Gln or its longer variants Pro-Gln/His-Gly-Gly-Gly-Gly-Trp-Gly-Gln. Out of 12 cattle, we found eight animals homozygous for genes with six copies of the Gly-rich peptide (6:6), while four were heterozygous (6:5). Two confirmed cases of BSE occurred in (6: 6) homozygous animals. Bovine spongiform encephalopathy (BSE) is a transmissible disease (Fraser et al., 1988; Dawson et al., 1990; Barlow & Middleton, 1990) which produces neuropathological lesions in cattle similar to those seen in ovine scrapie (Wells et al., 1987) and the rare human dementias Creutzfeldt-Jakob disease (CJD) and Gerstmann-Str/iussler syndrome (GSS) (Beck & Daniel, 1987). A cellular membrane protein (PrP) has a key role in the transmission and development of these diseases. This protein accumulates in the brain and other tissues during the protracted time course of these diseases and, in a disease-specific, protease-resistant isoform (SAF-PrP), has been purified by subcellular fractionation of scrapie

General limit to non-destructive optical detection of atoms

We demonstrate that there is a fundamental limit to the sensitivity of phase-based detection of atoms with light for a given maximum level of allowable spontaneous emission. This is a generalisation of previous results for two-level and three-level atoms. The limit is due to an upper bound on the phase shift that can be imparted on a laser beam for a given excited state population. Specifially, we show that no single-pass optical technique using classical light, based on any number of lasers or coherences between any number of levels, can exceed the limit imposed by the two-level atom. This puts significant restrictions on potential non-destructive optical measurement schemes.Comment: 7 pages, 1 figur

Pulse retrieval and soliton formation in a non-standard scheme for dynamic electromagnetically induced transparency

We examine in detail an alternative method of retrieving the information written into an atomic ensemble of three-level atoms using electromagnetically induced transparency. We find that the behavior of the retrieved pulse is strongly influenced by the relative collective atom-light coupling strengths of the two relevant transitions. When the collective atom-light coupling strength for the retrieval beam is the stronger of the two transitions, regeneration of the stored pulse is possible. Otherwise, we show the retrieval process can lead to creation of soliton-like pulses.Comment: 11 figure

How severe is antibiotic pharmacokinetic variability in critically ill patients and what can be done about it?

The pharmacokinetics (PK) of antimicrobial agents administered to critically ill patients exhibit marked variability. This variability results from pathophysiological changes that occur in critically ill patients. Changes in volume of distribution, clearance, and tissue penetration all affect the drug concentrations at the site of infection. PK-pharmacodynamic indices (fC(max):MIC; AUC(0-24):MIC; fT(>MIC); fC(min):MIC) for both antimicrobial effect and suppression of emergence of resistance are described for many antimicrobial drugs. Changing the regimen by which antimicrobial drugs are delivered can help overcome the PK variability and optimise target attainment. This will deliver optimised antimicrobial chemotherapy to individual critically ill patients. Delivery of beta-lactams antimicrobial agents by infusions, rather than bolus dosing, is effective at increasing the duration of the dosing interval that the drug concentration is above the MIC. Therapeutic drug monitoring, utilising population PK mathematical models with Bayesian estimation, can also be used to optimise regimens following measurement of plasma drug concentrations. Clinical trials are required to establish if patient outcomes can be improved by implementing these techniques. (C) 2014 Elsevier Inc. All rights reserved

Multimode quantum limits to the linewidth of an atom laser

The linewidth of an atom laser can be limited by excitation of higher energy modes in the source Bose-Einstein condensate, energy shifts in that condensate due to the atomic interactions, or phase diffusion of the lasing mode due to those interactions. The first two are effects that can be described with a semiclassical model, and have been studied in detail for both pumped and unpumped atom lasers. The third is a purely quantum statistical effect, and has been studied only in zero dimensional models. We examine an unpumped atom laser in one dimension using a quantum field theory using stochastic methods based on the truncated Wigner approach. This allows spatial and statistical effects to be examined simultaneously, and the linewidth limit for unpumped atom lasers is quantified in various limits.Comment: 8 Figure

Quantum kinetic theory model of a continuous atom laser

We investigate the feasible limits for realising a continuously evaporated atom laser with high-temperature sources. A plausible scheme for realising a truly continuous atom laser is to outcouple atoms from a partially condensed Bose gas, whilst continuously reloading the system with non-condensed thermal atoms and performing evaporative cooling. Here we use quantum kinetic theory to model this system and estimate feasible limits for the operation of such a scheme. For sufficiently high temperatures, the figure of merit for the source is shown to be the phase-space flux. The dominant process limiting the usage of sources with low phase-space flux is the three-body loss of the condensed gas. We conclude that certain double-magneto-optical trap (MOT) sources may produce substantial mean condensate numbers through continuous evaporation, and provide an atom laser source with a narrow linewidth and reasonable flux.Comment: 28 pages, 5 figure

Resonance fluorescence in a band gap material: Direct numerical simulation of non-Markovian evolution

A numerical method of calculating the non-Markovian evolution of a driven atom radiating into a structured continuum is developed. The formal solution for the atomic reduced density matrix is written as a Markovian algorithm by introducing a set of additional, virtual density matrices which follow, to the level of approximation of the algorithm, all the possible trajectories of the photons in the electromagnetic field. The technique is perturbative in the sense that more virtual density matrices are required as the product of the effective memory time and the effective coupling strength become larger. The number of density matrices required is given by $3^{M}$ where $M$ is the number of timesteps per memory time. The technique is applied to the problem of a driven two-level atom radiating close to a photonic band gap and the steady-state correlation function of the atom is calculated.Comment: 14 pages, 9 figure

Modelling the hepatitis B vaccination programme in prisons

A vaccination programme offering hepatitis B (HBV) vaccine at reception into prison has been introduced into selected prisons in England and Wales. Over the coming years it is anticipated this vaccination programme will be extended. A model has been developed to assess the potential impact of the programme on the vaccination coverage of prisoners, ex-prisoners, and injecting drug users (IDUs). Under a range of coverage scenarios, the model predicts the change over time in the vaccination status of new entrants to prison, current prisoners and IDUs in the community. The model predicts that at baseline in 2012 57% of the IDU population will be vaccinated with up to 72% being vaccinated depending on the vaccination scenario implemented. These results are sensitive to the size of the IDU population in England and Wales and the average time served by an IDU during each prison visit. IDUs that do not receive HBV vaccine in the community are at increased risk from HBV infection. The HBV vaccination programme in prisons is an effective way of vaccinating this hard-to-reach population although vaccination coverage on prison reception must be increased to achieve this

Squeezing and entanglement delay using slow light

We examine the interaction of a weak probe with $N$ atoms in a lambda-level configuration under the conditions of electromagnetically induced transparency (EIT). In contrast to previous works on EIT, we calculate the output state of the resultant slowly propagating light field while taking into account the effects of ground state dephasing and atomic noise for a more realistic model. In particular, we propose two experiments using slow light with a nonclassical probe field and show that two properties of the probe, entanglement and squeezing, characterizing the quantum state of the probe field, can be well-preserved throughout the passage.Comment: 2 figures; v2: fixed some minor typographical errors in a couple of equations and corrected author spelling in one reference. v3: Added three authors; changed the entaglement definition to conform to a more accepted standard (Duan's entanglement measure); altered the abstract slightly. v4: fixed formatting of figure