Treatment Of Hypertension In The Elderly Patient

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111195/1/j.1532-5415.1954.tb00881.x.pd

Renal and hypotensive effects of acute and chronic oral treatment with 1-hydrazinophthalazine (apresoline) in hypertension

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/32532/1/0000634.pd

Clinical observations on a new antihypertensive drug, 2-(2,6-dichlorphenylamine)-2-imidazoline hydrochloride

The drug 2-(2,6-dichlorphenylamine)-2-imidazoline hydrochloride, available as Catapres, was given to 16 patients with established hypertension. Six patients were studied for one month to detect abnormalities in carbohydrate metabolism. None were found. Ten severely hypertensive patients were maintained for from 5 to 11 months on Catapres and diuretics.In a single dose, Catapres invariably lowered the blood pressure significantly, but without producing orthostatic hypotension. The maximum effect occurred between 2 and 3 hours after ingestion of the drug. The duration of drug action was 4 to 6 hours.In long-term treatment of ten patients, Catapres, combined with a diuretic, proved to be as effective as a diuretic plus guanethidine or Aldomet, which the patients had previously been taking. A dose of 0.400 to 1.200 mg. of Catapres was equivalent to 1.5 to 2.0 Gm. of Aldomet or 50 to 100 mg. of guanethidine.The chief side effect of the drug was drowsiness, but this was not incapacitating, it did not require cessation of treatment, and it became less prominent with the passage of time. In patients who had experienced severe orthostatic hypotension on other drug regimens, the condition was considerably relieved by Catapres. No signs of toxicity were noted, as judged by carbohydrate tolerance, BUN, SGPT, alkaline phosphatase, and hematologic determinations.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/32994/1/0000378.pd

Synthesis, Molecular Structure, and 1H NMR Analysis of Bis(tetraphenylcyclopentadienyl)ruthenium(II)

Reaction of [Ru(p-cymene)Cl2]2 with K(η5-C5HPh4) in refluxing diglyme yields (η5-C5Ph4)2Ru in ca 50% yield. The complex was not susceptible to oxidation or reduction. (C5HPH4)2Ru crystallizes in the triclinic P1 space group with a = 8.549(4), b = 10.793(4), c = 12.842(5) Å, α = 65.98(3), β = 73.10(3), γ = 83.49(3)° and Z = 1. The least-squares data refined to R(F) = 3.53% and R(wF = 3.82% for the 3952 independent observed reflections with Fo ≥ 5σ(Fo). The metal-centroid distance is 1.832(2) Å and all other bond lengths and angles are similar to other octaphenylmetallocenes. 1H NMR analysis employing 2D J-resolved, COSY and low temperature techniques allowed assignment of all protons in the molecule. The motional processes of the phenyl groups are discussed

A study of hypertension in twins

A study of the blood pressure of 86 pairs of like-sexed twins over age 40 selected at random was performed. Twelve per cent were found to have a diastolic blood pressure in excess of 94 mm. Hg. In 4 out of 5 identical twin sets both members were found to have hypertension of about equal magnitude. In the fifth set, the predetermined definition of diastolic hypertension was not met in one member of the pair, although the systolic blood pressure was clearly elevated. In two identical twin sets, where information concerning previous blood pressure could be obtained, the age of onset of the hypertension differed. Among the 49 dizygetic twin sets, diastolic hypertension was found in 15 per cent of the individuals. In 3 of 12 of these pairs, it was present in both members.Since the prevalence of hypertension after age 40 in the identical twin sample resembles that in the population at large, it is concluded that the ultimate development of this condition is heavily dependent on genetic influences.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/32777/1/0000150.pd

Duality in the flat cohomology of curves

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46600/1/222_2005_Article_BF01390135.pd