Comparing Pfizer GeneSTAR and Igenity PROFILE DNA tests in Crossbred Cattle

Our objective was to compare the performance of Pfizer’s GeneSTAR and Igenity’s PROFILE DNA tests in crossbred beef cattle. Hair follicles were collected from 394 crossbred steers that were part of the South Dakota State University Calf Value Discovery project (n = 145) and calves that were fed at the SDSU Southeast Research Farm (n = 249) in 2011. Hair follicles were sent to Pfizer Animal Genetics and Igenity for testing with their GeneSTAR and PROFILE DNA tests, respectively. Marbling score (100-999 scale), ribeye area, fat thickness, carcass weight, yield grade, quality grade, and % kidney, pelvic, and heart fat was collected post-harvest on all steers. Using this dataset, we first asked whether each DNA test was associated with marbling scores. If the DNA tests were not associated with marbling, then the tests may not be useful for predicting genetic merit for marbling in crossbred cattle. The GeneSTAR and PROFILE DNA tests were associated with marbling scores, but this association was not high. Second, we asked whether GeneSTAR and PROFILE DNA test results were associated with each other. If test results were not correlated, then using both DNA test results together may improve genetic predictions. GeneSTAR and PROFILE tests for tenderness were highly correlated, suggesting that DNA markers for tenderness are similar for both tests. GeneSTAR and PROFILE DNA tests for marbling and feed efficiency were not highly correlated, raising the possibility that both tests could be used jointly to improve genetic predictions for these traits. However, using both GeneSTAR and PROFILE DNA tests jointly did not appreciably improve predictions for marbling score in our dataset. We conclude that, although both GeneSTAR and PROFILE DNA tests were associated with marbling score, the correlation between these tests and marbling was low in our sample of crossbred cattle. Further, using GeneSTAR and PROFILE DNA tests for marbling and feed efficiency may improve genetic predictions for these traits, but we did not find evidence that using both tests jointly improves predictions for marbling

Interferometry as a binary decision problem

Binary decision theory has been applied to the general interferometric problem. Optimal detection scheme-according to the Neyman-Pearson criterion-has been considered for different phase-enhanced states of radiation field, and the corresponding bounds on minimum detectable phase shift has been evaluated. A general bound on interferometric precision has been also obtained in terms of photon number fluctuations of the signal mode carrying the phase information.Comment: 9 pages. One picture in LaTeX. Epic and Eepic extension neede

Probing singularities in quantum cosmology with curvature scalars

We provide further evidence that the canonical quantization of cosmological models eliminates the classical Big Bang singularity, using the {\it DeBroglie-Bohm} interpretation of quantum mechanics. The usual criterion for absence of the Big Bang singularity in Friedmann-Robertson-Walker quantum cosmological models is the non-vanishing of the expectation value of the scale factor. We compute the `local expectation value' of the Ricci and Kretschmann scalars, for some quantum FRW models. We show that they are finite for all time. Since these scalars are elements of general scalar polynomials in the metric and the Riemann tensor, this result indicates that, for the quantum models treated here, the `local expectation value' of these general scalar polynomials should be finite everywhere. Therefore, we have further evidence that the quantization of the models treated here eliminates the classical Big Bang singularity. PACS: 04.40.Nr, 04.60.Ds, 98.80.Qc.Comment: 9 pages, 6 figure

Measurement of Fluorescence Phenomena from Yttrium and Gadolinium Oxysulfide Phosphors using a 45-MeV Proton Beam

This research was sponsored by the National Science Foundation Grant NSF PHY-931478

Effect of electronic angular momentum exchange on photoelectron anisotropy following the two-colour ionization of krypton atoms

We present photoelectron energy and angular distributions for resonant two-photon ionization via several low-lying Rydberg states of atomic Kr. The experiments were performed by using synchrotron radiation to pump the Rydberg states and a continuous wave laser to probe them. Photoelectron images, recorded with both linear and circular polarized pump and probe light, were obtained in coincidence with mass-analyzed Kr ions. The photoelectron angular distributions and branching ratios for direct ionization into the Kr+ 2P3/2 and 2P1/2 spin-orbit continua show considerable dependence on the intermediate level, as well as on the polarizations of the pump and probe light. Photoelectron angular distributions were also recorded with several polarization combinations following two-colour excitation of the (2P1/2)5f[5/2]2 autoionizing resonance. These results are compared with the results of recent work on the corresponding autoionizing resonance in atomic Xe

An overview and prospective on Al and Al-ion battery technologies

Aluminum batteries are considered compelling electrochemical energy storage systems because of the natural abundance of aluminum, the high charge storage capacity of aluminum of 2980 mA h g−1/8046 mA h cm−3, and the sufficiently low redox potential of Al3+/Al. Several electrochemical storage technologies based on aluminum have been proposed so far. This review classifies the types of reported Al-batteries into two main groups: aqueous (Al-ion, and Al-air) and non-aqueous (aluminum graphite dual-ion, Al-organic dual-ion, Al-ion, and Al-sulfur). Specific focus is given to Al electrolyte chemistry based on chloroaluminate melts, deep eutectic solvents, polymers, and “chlorine-free” formulations

Quantum trajectory perspective of atom-field interaction in attosecond time scale

Here the ionization and high harmonic generation in Hydrogen and Helium by using quantum (hydrodynamic) trajectories is analyzed theoretically. The quantum trajectories allow a self-contained treatment of the electron exchange and correlation effects without introducing ad hoc potentials into the Schrodinger equation. Our approach predicts the correct high harmonic spectra and the attosecond pulses generated by the Helium atom beyond the single active electron approximation. It can be used to study complex multi-electron systems and their interaction with laser field of both high and low intensity.Comment: 8 pages, 4 figure

Use of Z-pinch radiation sources for high-pressure shock wave studies

The authors are developing a new shock wave diagnostic using Z pinch sources for high-pressure equation of state (EOS) measurements. Specifically, they are employing VISAR interferometry to measure the particle velocity of shocked materials and fiber optic probes to measure the shock speed. Combination of these measurements will allow absolute EOS data with Z accelerators. This report is a progress report on the development of this new approach to EOS measurements; however, preliminary data obtained with the diagnostics are encouraging. With further development of Z pinch sources, it is envisioned that a variety of EOS and constitutive property measurements can be made. Time-resolved wave profile measurements will then provide a variety of EOS and material property data, such as isentropic EOS, initial compressive strength and shock-induced compressive strength, dynamic tensile strength, kinetics of phase transitions, and surface stability studies

Long-term exposures to air pollution and the risk of atrial fibrillation in the women’s health initiative cohort

BACKGROUND: Atrial fibrillation (AF) is associated with substantial morbidity and mortality. Short-term exposures to air pollution have been associated with AF triggering; less is known regarding associations between long-term air pollution exposures and AF incidence. OBJECTIVES: Our objective was to assess the association between long-term exposures to air pollution and distance to road on incidence of AF in a cohort of U.S. women. METHODS: We assessed the association of high resolution spatiotemporal model predictions of long-term exposures to particulate matter (PM10 and PM2:5 ), sulfur dioxide (SO2 ), nitrogen dioxide (NO2 ), and distance to major roads with incidence of AF diagnosis, identified through Medicare link-age, among 83,117 women in the prospective Women’s Health Initiative cohort, followed from enrollment in Medicare through December 2012, incidence of AF, or death. Using time-varying Cox proportional hazards models adjusted for age, race/ethnicity, study component, body mass index, physical activity, menopausal hormone therapy, smoking, diet quality, alcohol consumption, educational attainment, and neighborhood socioeconomic status, we estimated the relative risk of incident AF in association with each pollutant. RESULTS: A total of 16,348 incident AF cases were observed over 660,236 person-years of follow-up. Most exposure–response associations were non-linear. NO2 was associated with risk of AF in multivariable adjusted models [Hazard Ratio ðHRÞ = 1:18; 95% confidence interval (CI): 1.13, 1.24, comparing the top to bottom quartile, p-for-trend = < 0:0001]. Women living closer to roadways were at higher risk of AF (e.g., HR = 1:07; 95% CI: 1.01, 1.13 for living within 50 m of A3 roads, compared with ≥1,000 m, p-for-trend = 0:02), but we did not observe adverse associations with exposures to PM10, PM2:5, or SO2 . There were adverse associations with PM10 (top quartile HR = 1:10; 95% CI: 1.05, 1.16, p-for-trend = &lt; 0:0001) and PM2:5 (top quartile HR = 1:09; 95% CI: 1.03, 1.14, p-for-trend = 0:002) in sensitivity models adjusting for census region. DISCUSSION: In this study of postmenopausal women, NO2 and distance to road were consistently associated with higher risk of AF. https://doi.org/10.1289/EHP7683