44 research outputs found
The Inhibition of Acetylcholinesterase by Organophosphorus Compounds and its Reversal [ Abridged
No full textThe importance of the position of the quaternary nitrogen atom in the molecule of certain compounds to their ability to react with true cholinesterase and pseudocholinesterase
No full text
Blood levels, urinary excretion and potential toxicity of N, N′-trimethylenebis (pyridinium 4-aldoxime) dichloride (TMB-4) in healthy man following intramuscular injection of the oxime
No full textPharmacokinetics of 619C89, a novel neuronal sodium channel inhibitor, in acute stroke patients after loading and discrete maintenance infusions
No full text1This was a multi-centre, placebo controlled, randomized, dose-escalating design study in which five dosing regimens of 619C89/placebo were evaluated in 48 stroke patients. Loading infusions of 0.5, 1, 1.5, 2 and 2.5 mg kg−1 over 1 h were followed by respective maintenance infusions of 0.25, 0.5, 0.75, 1 and 1.25 mg kg−1 over 30 min at 8 hourly intervals for 3 days
