Skeletal aging and the adipocyte program: New insights from an “old” molecule

Aging is associated with profound changes in bone mass and body composition. Emerging evidence supports the hypothesis that alterations in mesenchymal stromal cell fate are a critical etiologic factor. In addition, timekeeping at the cellular level is affected as aging progresses, particularly in the adipocyte. In this Extra View we discuss the interactive role of three molecules, PPARγ, nocturnin and IGF-I, in regulating stem cell fate in the marrow and the potential implications of this network for understanding cellular aging

Mex3c regulates insulin-like growth factor 1 (IGF1) expression and promotes postnatal growth

Mex3c is highly expressed in the testis, brain, and developing bone. Mex3c mutation causes postnatal growth retardation and background-dependent perinatal lethality, possibly through impairing the translation of insulin-like growth factor 1 mRNA in bone-forming cells