Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage.

Pancreatic cancer is one of the fatal causes of global cancer-related deaths. Although surgery and chemotherapy are standard treatment options, post-treatment outcomes often end in a poor prognosis. In the present study, we investigated anti-pancreatic cancer and amelioration of radiation-induced oxidative damage by crocin. Crocin is a carotenoid isolated from the dietary herb saffron, a prospect for novel leads as an anti-cancer agent. Crocin significantly reduced cell viability of BXPC3 and Capan-2 by triggering caspase signaling via the downregulation of Bcl-2. It modulated the expression of cell cycle signaling proteins P53, P21, P27, CDK2, c-MYC, Cyt-c and P38. Concomitantly, crocin treatment-induced apoptosis by inducing the release of cytochrome c from mitochondria to cytosol. Microarray analysis of the expression signature of genes induced by crocin showed a substantial number of genes involved in cell signaling pathways and checkpoints (723) are significantly affected by crocin. In mice bearing pancreatic tumors, crocin significantly reduced tumor burden without a change in body weight. Additionally, it showed significant protection against radiation-induced hepatic oxidative damage, reduced the levels of hepatic toxicity and preserved liver morphology. These findings indicate that crocin has a potential role in the treatment, prevention and management of pancreatic cancer

Oxidation and oxygen diffusion in Ti-6al-4V alloy: improving measurements during sims analysis by rotating the sample

Titanium alloys are attractive to the industrial world, as they offer the benefits of low density, great corrosion resistance, and relatively good strength, making them viable candidates for a multitude of applications. However, above 500 °C, oxidation and oxygen diffusion in titanium alloys need to be taken into account as they change their microstructure and then their mechanical properties. Oxidations were carried out between 600 and 750 °C on a specific titanium alloy: an a-b annealed Ti-6Al-4V. Oxidation kinetics and oxygen diffusion in the matrix were studied. SIMS analyses were realized on rotating specimens of this two-phase polycrystalline alloy in order to reduce roughness. Composition profiles along the sample thickness were compared to microhardness measurements. SIMS mappings were realized on the smooth slopes of the crater

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Not AvailableHill State of Himachal Pradesh, Jammu and Kashmir Uttarakhand in north-western Himalayan region have so far remained tradional in agriculture despite the adequate research and infrastructure develoment. Nearly 82 percent of the farmers are either small or marginal nad are women with land holdings of legs than 2 hectares which are widely scattered in remote villages.Not Availabl

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Not Availableवर्तमान में आवश्यकता है कि खास फसलों पर निर्भरता कम की जाए तथा अन्य पौधों को खाद्य फसलों के रूप मे अधिक से अधिक प्रयोग में लाया जा सके जिस्सके की भविस्यकल में आने वाले किसी भी संकट से बचा जा सके।Not Availabl

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Not AvailableAmaranthus, collectively known as amarnath or pigweed, is a cosmopolitan genus of herbs. Amarnaths are fast growing cereal like plants that produce high protein and minerals . Amarnaths belong to thwe family Amarnathaceaae and are referred as pseudo-cereal to distinguish then from true cereals which belong to family Gramineae/ Poaceae.Not Availabl

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Not Availableमतीरा सूखा सहन करने वाले कुकुरबिटेसी परिवार का वार्षिक बेल रूपी पौधा है। यह तरबूज तथा तम्बू का कुदरती संकर है। उत्तर-पश्चिमी भारत के सूस्का क्षेत्रो में यह कलिगंडा के नाम से जाना जाता है।एह कम उर्वरा शक्ति वाली भूमि पर भी आसानी से उगाया जा सकता है ।Not Availabl

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Not AvailableRice bean also known as climbing bean, mountain bean, mambi bean, Oriental bean, haricoat bean, Red bean and Jerusalern pea, is highly branched annual with erect or semi erect stem tending to be viny. In India it is known by differnt names such as moth, Rajmoong and Satrangi mash.Not Availabl