12 research outputs found
Effects of composition variations and curing conditions on the gloss of water reducible clear coatings prepared from palm stearin alkyds
Formation of todorokite from âc-disorderedâ H+-birnessites: the roles of average manganese oxidation state and interlayer cations
Metamorphic zoning and geodynamic evolution of an inverted crustal section (Karakorum margin, N Pakistan), evidence for two metamorphic events
DDX17 is involved in DNA damage repair and modifies FUS toxicity in an RGG-domain dependent manner
Carboxypeptidase G2-based gene-directed enzymeâprodrug therapy: a new weapon in the GDEPT armoury
Gene-directed enzyme-prodrug therapy (GDEPT) aims to improve the therapeutic ratio ( benefit versus toxic side-effects) of cancer chemotherapy. A gene encoding a 'suicide' enzyme is introduced into the tumour to convert a subsequently administered non-toxic prodrug into an active drug selectively in the tumour, but not in normal tissues. Significant effects can now be achieved in vitro and in targeted experimental models, and GDEPT therapies are entering the clinic. Our group has developed a GDEPT system that uses the bacterial enzyme carboxypeptidase G2 to convert nitrogen mustard prodrugs into potent DNA crosslinking agents, and a clinical trial of this system is pending