11 research outputs found
Long Term Outcome after Application of the Angio-Seal Vascular Closure Device in Minipigs
Körper und Mensch in der sportlichen Bewegung – anthropologische und kulturwissenschaftliche Grundlagen
Atypical Signaling and Functional Desensitization Response of MAS Receptor to Peptide Ligands
The peptide network regulated by angiotensin converting enzyme (ACE) in hematopoiesis
The concept of a local bone marrow renin-angiotensin system (RAS) has been introduced and accumulating evidence suggests that the local RAS is actively involved in hematopoiesis. Angiotensin converting enzyme (ACE) is a key player in the RAS and makes the final effector angiotensin II. Besides angiotensin II, ACE also regulates a panel of bioactive peptides, such as substance P, Ac-SDKP and angiotensin 1–7. These peptides have also been individually reported in the regulation of pathways of hematopoiesis. In this setting, an ACE-regulated peptide network orchestrating hematopoiesis has emerged. Here, we focus on this peptide network and discuss the roles of ACE and its peptides in aspects of hematopoiesis. Special attention is given to the recent revelation that ACE is a bona fide marker of hematopoietic stem cells