4 research outputs found
Development of three-dimensional printing filaments based on poly(lactic acid)/hydroxyapatite composites with potential for tissue engineering
Tetracycline hydrochloride (TCH)-loaded drug carrier based on PLA:PCL nanofibre mats: experimental characterisation and release kinetics modelling
The experimental characterisation of electrospun poly(lactic acid) (PLA): poly(e-caprolactone) (PCL) as drug carriers, at five blend ratios from 1:0, 3:1, 1:1, 1:3 and 0:1, was holistically investigated in terms of their morphological structures, crystallinity levels and thermal properties. A widely used antibiotic tetracycline hydrochloride (TCH) was loaded to prepared fibrous mats at TCH concentrations of 1 and 5 wt%. The additional TCH into PLA: PCL better facilitates the reduction of fibre diameter than polymer blends. Increasing the TCH concentration from 1 to 5 wt% was found to result in only a modest decrease in the crystallinity level, but a significant increase in the crystallisation temperature (Tc) for PLA within PLA: PCL blends. The infrared spectra of fibre mats confirm the successful TCH encapsulation into fibrous networks. The first order and Zeng models for drug release kinetics were in better agreement with experimental release data, indicating the release acceleration of TCH with increasing its concentration. In a typical case of PLA: PCL (1:1) loaded with 5 wt% TCH, the fibre mats apparently demonstrate more wrinkled and floppy structures and increased fibre diameters and decreased inter-fibrous spaces after 7-day in vitro fibre degradation, as opposed to those obtained after 3-h degradation
Introducing electrospun polylactic acid incorporating etched halloysite nanotubes as a new nanofibrous web for controlled release of Amoxicillin
Effect of surface functionalization of halloysite nanotubes on synthesis and thermal properties of poly(Īµ-caprolactone)
In this work, halloysite nanotubes (HNTs) and functionalized HNTsāAPTES (aminopropyltriethoxysilane) in concentrations 0.5, 1 and 2.5Ā wt% were used as nanofillers in the synthesis of poly(Īµ-caprolactone) (PCL) nanocomposites via the in situ ring-opening polymerization of Īµ-caprolactone (CL). The successful functionalization of HNTs was confirmed with X-ray photoelectron spectroscopy. The effects of HNTs and HNTsāAPTES on the polymerization procedure and on the thermal properties of PCL were studied in detail. It was found that both nanofillers reduced the MĀÆ n values of the resulting nanocomposites, with the unfunctionalized one reducing it in a higher extent, while SEM micrographs indicated satisfactory dispersion in the PCL matrix. The crystallization study under isothermal and dynamic conditions revealed the nucleating effect of the nanotubes. The functionalization of nanotubes enabled even faster rates and attributed higher nucleation activity as a result of better dispersion and the formation of a strong interface between the filler and the matrix. An in-depth kinetic analysis was performed based on the data from crystallization procedures. PLOM images confirmed the effectiveness of both fillers as heterogeneous nucleation agents. Finally, from TGA analysis, it was found that HNTs did not affect the thermal stability of PCL while for HNTsāAPTES, a small decrease in Tmax was observed, of about 5Ā Ā°C for all filler contents.</p