Optimising intraperitoneal gentamicin dosing in peritoneal dialysis patients with peritonitis (GIPD) study

Background: Antibiotics are preferentially delivered via the peritoneal route to treat peritonitis, a major complication of peritoneal dialysis (PD), so that maximal concentrations are delivered at the site of infection. However, drugs administered intraperitoneally can be absorbed into the systemic circulation. Drugs excreted by the kidneys accumulate in PD patients, increasing the risk of toxicity. The aim of this study is to examine a model of gentamicin pharmacokinetics and to develop an intraperitoneal drug dosing regime that maximises bacterial killing and minimises toxicity

A survey of graph edit distance

Inexact graph matching has been one of the significant research foci in the area of pattern analysis. As an important way to measure the similarity between pairwise graphs error-tolerantly, graph edit distance (GED) is the base of inexact graph matching. The research advance of GED is surveyed in order to provide a review of the existing literatures and offer some insights into the studies of GED. Since graphs may be attributed or non-attributed and the definition of costs for edit operations is various, the existing GED algorithms are categorized according to these two factors and described in detail. After these algorithms are analyzed and their limitations are identified, several promising directions for further research are proposed

Conversion of levulinic acid to valuable chemicals: a review

Levulinic acid (LA), a class of important chemical intermediates and new energy chemicals, has been considered one of the top-12 platform compounds that can be converted from biomass resources. Substantial progress on the conversion of lignocellulose biomass to LA and the further conversion of LA to high value downstream chemicals have been achieved recently. This review summarizes the preparation and separation processes of LA firstly, and then, emphatically discusses the catalytic system for LA conversion to valuable downstream products, including levulinate esters, 2-methyl tetrahydrofuran (MTHF), Gamma-valerolactone (GVL), 5-aminolevulinic acid (DALA), and diphenolic acid (DPA). An outlook is provided at the end of this paper to highlight the challenges and opportunities for the comprehensive utilization of lignocellulose biomass. (c) 2021 Society of Chemical Industry (SCI)