ANTIMICROBIAL EVALUATION OF MALEIMIDE MONOMERS, HOMOPOLYMERS AND COPOLYMERS CONTAINING AZO, SULPHONAMIDE AND THIAZOLE GROUPS

New maleimide Monomers, homopolymers and copolymers  containing azo, sulfonamide and thiazole groups were synthesized. The structures of newly synthesized compounds have been characterized on the basis of their spectroscopic data (FT-IR and 1H-NMR).  Antimicrobial studies of synthesized compounds were performed using agar well diffusion method. All the compounds showed pronounced activity against bacterial strains in comparison to activity against fungal strains.The highest antibacterial potency was exhibited by the homopolymer HPSPMI against Escherichia coli, Klebsiella pneumoniae and Bacillus subtilis.  The activity of  HPSPMI against later two was more pronounced than the standard drug used. Only Selected compounds showed antifungal activity. Appreciable results were found against Aspergillus fumigates but not with Candida albicans. HPSPMI showed highest activity against Aspergillus fumigates. Surprisingly after homo and copolymerization, maximum compounds exhibited not only pronounced antibacterial activity but also antifungal activity.Â

Oxidation of phenyl alanine by pyridinium chlorochromate in acidic DMF–water medium: A kinetic study

AbstractThe kinetics of oxidation of phenyl alanine by pyridinium chlorochromate in DMF–water (70:30%) mixture in presence of perchloric acid leads to the formation of corresponding aldehyde. The reaction is of first order each in [PCC], [HClO4] and [AA]. Michaelis–Menten type kinetics was observed with phenyl alanine. The reaction rates were determined at different temperatures [25, 30, 35, 40, 45, 50°C] and the activation parameters were calculated. The reaction does not induce polymerization of acrylonitrile. With an increase in the amount of DMF in its aqueous mixture, the rate increases. A suitable mechanism for the reaction was postulated