The influence of rifle carriage on the kinetics of human gait

The influence that rifle carriage has on human gait has received little attention in the published literature. Rifle carriage has two main effects, to add load to the anterior of the body and to restrict natural arm swing patterns. Kinetic data were collected from 15 male participants, with 10 trials in each of four experimental conditions. The conditions were: walking without a load (used as a control condition); carrying a lightweight rifle simulator, which restricted arm movements but applied no additional load; wearing a 4.4 kg diving belt, which allowed arms to move freely; carrying a weighted (4.4 kg) replica SA80 rifle. Walking speed was fixed at 1.5 m/s (+5%) and data were sampled at 400 Hz. Results showed that rifle carriage significantly alters the ground reaction forces produced during walking, the most important effects being an increase in the impact peak and mediolateral forces. This study suggests that these effects are due to the increased range of motion of the body’s centre of mass caused by the impeding of natural arm swing patterns. The subsequent effect on the potential development of injuries in rifle carriers is unknown

DOES AN EXTRA MASS IMPROVE THE ARM SWING SPEED?

This study investigated the effect of adding extra mass on individual segments during the performance of an arm swing task in the horizontal plane. The amount of extra mass was 0, 25, 50, 75, and 100% of the mass of the segment on which the extra mass was placed (upper arm or forearm). The variables studied were arm swing speed (hand speed), positive muscle impulse, and system moment of inertia (MOI). The purpose was to see if adding extra mass sped up or slowed down the arm swing and why. Twenty subjects were instructed to produce their maximum hand swing speed over the target point during the horizontal non-dominant arm swing. It was found that the forearm extra mass elicited a significant decrease in the arm swing speed, while the upper arm added mass did not cause decreases in arm speed. Rather, moderate amounts of extra mass at the upper arm (25 and 50% extra mass) induced slight, although not significant, increases in arm swing speed (0.66% and 1.41% increase, respectively). These increases in speed were accompanied by small increases in both the positive muscle impulse and the system MOI with the upper arm extra mass. Significant increases in the system MOI accounted for the significant swing speed drop caused by the forearm extra mass. It was concluded that extra mass is not always detrimental to the arm swing speed. Extra mass added close to the axis of rotation either makes no difference or may actually help swing speed

Molecular Approaches to Sarcoma Therapy

Soft tissue sarcomas comprise a heterogeneous group of aggressive tumors that have a relatively poor prognosis. Although conventional therapeutic regimens can effectively cytoreduce the overall tumor mass, they fail to consistently achieve a curative outcome. Alternative gene-based approaches that counteract the underlying neoplastic process by eliminating the clonal aberrations that potentiate malignant behavior have been proposed. As compared to the accumulation of gene alterations associated with epithelial carcinomas, sarcomas are frequently characterized by the unique presence of a single chromosomal translocation in each histological subtype. Similar to the Philadelphia chromosome associated with CML, these clonal abnormalities result in the fusion of two independent unrelated genes to generate a unique chimeric protein that displays aberrant activity believed to initiate cellular transformation. Secondary gene mutations may provide an additional growth advantage that further contributes to malignant progression. The recent clinical success of the tyrosine kinase inhibitor, STI571, suggests that therapeutic approaches specifically directed against essential survival factors in sarcoma cells may be effective. This review summarizes published approaches targeting a specific molecular mechanism associated with sarcomagenesis. The strategy and significance of published translational studies in six distinct areas are presented. These include: (1) the disruption of chimeric transcription factor activity; (2) inhibition of growth stimulatory post-translational modifications; (3) restoration of tumor suppressor function; (4) interference with angiogenesis; (5) induction of apoptotic pathways; and (6) introduction of toxic gene products. The potential for improving outcomes in sarcoma patients and the conceptual obstacles to be overcome are discussed

EFFECTS OF HANDLE AND BLOCK CONFIGURATION ON SWIM START PERFORMANCE

The purpose of this study was to quantify differences in swimming track start performances using side handle and front handle grip techniques and using an inclined platform at the rear of the starting platform. An instrumented starting block system was designed to allow front grip and side grip starting techniques and inclusion of a rear incline. Thirty male and 20 female junior elite swimmers completed three starts in each of four start block configurations: (1) Flat (traditional) block, front handle grip; (2) Flat (traditional) block, side handle grip; (3) Incline (new) block, front handle grip; (4) Incline (new) block, side handle grip. Force and video data were used to quantify parameters related to starting performance. Results indicated that use of side handles had a substantial impact on start performance while the effects of the rear incline were less pronounced. Compared to using a front grip technique, use of the side handles increased horizontal velocity at takeoff up to 18%, resulted in a more horizontal takeoff angle by up to 2°, increased contribution to horizontal impulse from arms up to 12%, increased peak horizontal power up to 28%, decreased time to 6 m by 4% and increased velocity at 6 m by 2.5%. These advantages were achieved at a cost of an 8% increase in propulsion time. Based on this study, we recommend swimmers develop familiarity with the use of side handles when performing a track start and to use this technique if handles are available on a starting block

A note on Makeev's conjectures

A counterexample is given for the Knaster-like conjecture of Makeev for functions on $S^2$. Some particular cases of another conjecture of Makeev, on inscribing a quadrangle into a smooth simple closed curve, are solved positively

Oligomerization of Bacterially Expressed H1N1 Recombinant Hemagglutinin Contributes to Protection Against Viral Challenge

Vaccination is the most effective intervention to prevent influenza and control the spread of the virus. Alternatives are needed to the traditional egg-based vaccine strategy for a more rapid response to new outbreaks. Two different hemagglutinin (HA) fragments (rHA11-326 and rHA153-269) derived from influenza A virus subtype H1N1 were expressed in Escherichia coli and characterized by immunoblot, gel filtration, hemagglutination, and competitive binding assays. rHA11-326 included neutralizing epitopes and the trimerization domain, whereas rHA153-269 included only the head of HA with the neutralizing epitopes. Mice were immunized with rHA11-326 or rHA153-269, and sera were tested for the presence of neutralizing antibodies. Mice were then challenged with H1N1 and infection severity was monitored. rHA11-326 trimerized, whereas rHA153-269 was unable to form oligomers. Both rHA11-326 and rHA153-269 elicited the production of neutralizing antibodies, but only oligomerized rHA11-326 protected against live virus challenges in mice. This study demonstrated that bacterially expressed HA was capable of folding properly and eliciting the production of neutralizing antibodies, and that HA oligomerization contributed to protection against viral challenge. Therefore, prokaryotic-derived vaccine platforms can provide antigenic and structural requirements for viral protection, as well as allow for the rapid and cost-effective incorporation of multiple antigens for broader protection