Exercise-induced respiratory muscle work: Effects on blood flow, fatigue and performance

This is the post print version of this article. The official published version can be obtained from the link below.In healthy subjects, heavy intensity endurance exercise places substantial demands on the respiratory muscles as breathing frequency, ventilation and the work of breathing rise over time. In the highly trained subject working at high absolute work rates, the ventilatory demand often causes varying degrees of expiratory flow limitation, sometimes accompanied by lung hyperinflation and, therefore, increased elastic work of breathing. Time-dependant increases in effort perceptions for both dyspnea and limb discomfort accompany these increased ventilatory demands. Similar responses to endurance exercise but at much lower exercise intensities also occur in patients with COPD and CHF. Note that these responses significantly influence exercise performance times in both health and disease. This effect was demonstrated by the marked reductions in the rate of rise of effort perceptions and the enhanced exercise performance times elicited by unloading the respiratory muscles using pressure support ventilation or proportional assist mechanical ventilation. In healthy fit subjects, unloading the inspiratory work of breathing by about one half increased performance by an average of 14% (Harms et al. 2000), and in CHF and COPD patients performance time more than doubled with respiratory muscle unloading (O’Donnell et al. 2001). Why are effort perceptions of limb discomfort markedly reduced and exercise performance increased when the respiratory muscles are unloaded? Our hypothesis is shown in Fig. 1

On search for new Higgs physics in CDF at the Tevatron

We discuss the Higgs boson mass sum rules in the Minimal Supersymmetric Standard Model in order to estimate the upper limits on the masses of stop quarks as well as the lower bounds on the masses of the scalar Higgs boson state. The bounds on the scale of quark-lepton compositeness derived from the CDF Collaboration (Fermilab Tevatron) data and applied to new extra gauge boson search is taken into account. These extra gauge bosons are considered in the framework of the extended SU(2)_h \times SU(2)_l model. In addition, we discuss the physics of rare decays of the MSSM Higgs bosons in both CP-even and CP-odd sectors and also some extra gauge bosons.Comment: 24 pages, LaTeX, 8 figure

Localized Fermions and Anomaly Inflow via Deconstruction

We study fermion localization in gauge theory space. We consider four dimensional product gauge groups in which light chiral fermions transform under different gauge factors of the product group. This construction provides a suppression of higher dimensional operators. For example, it can be used to suppress dangerous proton decay operators. The anomalies associated with the light chiral fermions are compensated by Wess-Zumino terms, which in the continuum limit reproduce the five dimensional Chern-Simons term.Comment: 12 pages, minor changes to section

Littlest Higgs model and associated ZH production at high energy e+e−e^{+}e^{-} collider

In the context of the littlest Higgs (LH) model, we consider the Higgs strahlung process $e^{+}e^{-}\to ZH$. We find that the correction effects on this process mainly come from the heavy photon $B'$. If we take the mixing angle parameter $c$ in the range of 0.75 - 1, the contributions of the heavy gauge boson $W_{3}'$ is larger than 6%. In most of the parameter space, the deviation of the total production cross section $\sigma^{tot}$ from its SM value is larger than 5%, which may be detected in the future high energy $e^{+}e^{-}$ collider (LC) experiments. The future LC experiments could test the LH model by measuring the cross section of the process $e^{+}e^{-}\to ZH$.Comment: 13 pages, 3 figure

Novel Plasmodium falciparum clones and rising clone multiplicities are associated with the increase in malaria morbidity in Ghanaian children during the transition into the high transmission season

A survey of Plasmodium falciparum infection and clone multiplicity in Ghanaian children was carried out to study the effect of the onset of the malaria transmission season on disease incidence. Fortnightly blood samples were collected from 40 children living in the rural town of Dodowa, between February and August 1998. P. falciparum parasite densities were calculated and PCR genotyping was carried out using the polymorphic MSP-1 and MSP-2 genes as target loci for the estimation of the number of parasite clones in each sample. The average clone number was estimated using maximum likelihood techniques and the minimum number of clones per patient was analysed for the effects of age, sex, season, minimum number of clones per child, level of parasitaemia and parasite genotype. The statistical analysis indicated that the more clones a child carried, the more likely they were to have a clinical malaria episode. This was true after adjusting for age and season effects and for the measured circulating parasitaemia. The probability of clinical disease also increased if the MSP-1 MAD 20 and the MSP-2 FC 27 alleles were present. This longitudinal analysis thus indicates that the probability of a Ghanaian child having a symptomatic malaria episode is positively associated with both increasing numbers and novel types of P. falciparum clones

Beautiful Mirrors and Precision Electroweak Data

The Standard Model (SM) with a light Higgs boson provides a very good description of the precision electroweak observable data coming from the LEP, SLD and Tevatron experiments. Most of the observables, with the notable exception of the forward-backward asymmetry of the bottom quark, point towards a Higgs mass far below its current experimental bound. The disagreement, within the SM, between the values for the weak mixing angle as obtained from the measurement of the leptonic and hadronic asymmetries at lepton colliders, may be taken to indicate new physics contributions to the precision electroweak observables. In this article we investigate the possibility that the inclusion of additional bottom-like quarks could help resolve this discrepancy. Two inequivalent assignments for these new quarks are analysed. The resultant fits to the electroweak data show a significant improvement when compared to that obtained in the SM. While in one of the examples analyzed, the exotic quarks are predicted to be light, with masses below 300 GeV, and the Higgs tends to be heavy, in the second one the Higgs is predicted to be light, with a mass below 250 GeV, while the quarks tend to be heavy, with masses of about 800 GeV. The collider signatures associated with the new exotic quarks, as well as the question of unification of couplings within these models and a possible cosmological implication of the new physical degrees of freedom at the weak scale are also discussed.Comment: 21 pages, 4 embedded postscript figures, LaTeX. Two minor corrections performe

Neutral top-pion and lepton flavor violating processes

In the context of topcolor-assisted techicolor(TC2) models, we study the contributions of the neutral top-pion $\pi^{0}_{t}$ to the lepton flavor violating(LFV) processes $l_{i}\to l_{j}\gamma$ and $l_{i}\to l_{j}l_{k}l_{l}$. We find that the present experimental bound on $\mu\to e\gamma$ gives severe constraints on the free parameters of $TC2$ models. Taking into account these constraints, we consider the processes $l_{i}\to l_{j}l_{k}l_{l}$ generated by top-pion exchange at the tree-level and the one loop level, and obtain $Br(\mu\to 3e)\simeq 2.87\times 10^{-14}$, $1.1\times 10^{-15}\leq Br(\tau\to 3e)\simeq Br(\tau\to 2e\mu)\leq 4.4 \times 10^{-15}$, $3.1\times 10^{-15} \leq Br(\tau\to 2\mu e)\simeq Br(\tau\to 3\mu)\leq 1.5 \times 10^{-14}$ in most of the parameter space.Comment: latex files,16 pages, 6 figures. Submitted to Phys. Rev.

Yukawa Deflected Gauge Mediation in Four Dimensions

We construct a four dimensional realization of a higher dimensional model, Yukawa deflected gauge mediation, in which supersymmetry breaking is communicated to the visible sector through both gauge and Yukawa interactions. The reduction to four dimensions is achieved by `deconstructing' or `latticizing' the extra dimension. Three sites (gauge groups) are sufficient to reproduce the spectrum of the higher dimensional model. The characteristic features of Yukawa deflected gauge mediation, in particular, alignment of squarks and quarks, and a natural solution to the mu problem, carry over to the deconstructed version of the model. We comment on the implications of our results for a solution of the mu problem in the context of deconstructed gaugino mediation.Comment: 11 pages, 1figur

Energy Release During Slow Long Duration Flares Observed by RHESSI

Slow Long Duration Events (SLDEs) are flares characterized by long duration of rising phase. In many such cases impulsive phase is weak with lack of typical short-lasting pulses. Instead of that smooth, long-lasting Hard X-ray (HXR) emission is observed. We analysed hard X-ray emission and morphology of six selected SLDEs. In our analysis we utilized data from RHESSI and GOES satellites. Physical parameters of HXR sources were obtained from imaging spectroscopy and were used for the energy balance analysis. Characteristic time of heating rate decrease, after reaching its maximum value, is very long, which explains long rising phase of these flares.Comment: Accepted for publication in Solar Physic

Self-diffusion in dense granular shear flows

Diffusivity is a key quantity in describing velocity fluctuations in granular materials. These fluctuations are the basis of many thermodynamic and hydrodynamic models which aim to provide a statistical description of granular systems. We present experimental results on diffusivity in dense, granular shear in a 2D Couette geometry. We find that self-diffusivities are proportional to the local shear rate with diffusivities along the mean flow approximately twice as large as those in the perpendicular direction. The magnitude of the diffusivity is D \approx \dot\gamma a^2 where a is the particle radius. However, the gradient in shear rate, coupling to the mean flow, and drag at the moving boundary lead to particle displacements that can appear sub- or super-diffusive. In particular, diffusion appears superdiffusive along the mean flow direction due to Taylor dispersion effects and subdiffusive along the perpendicular direction due to the gradient in shear rate. The anisotropic force network leads to an additional anisotropy in the diffusivity that is a property of dense systems with no obvious analog in rapid flows. Specifically, the diffusivity is supressed along the direction of the strong force network. A simple random walk simulation reproduces the key features of the data, such as the apparent superdiffusive and subdiffusive behavior arising from the mean flow, confirming the underlying diffusive motion. The additional anisotropy is not observed in the simulation since the strong force network is not included. Examples of correlated motion, such as transient vortices, and Levy flights are also observed. Although correlated motion creates velocity fields qualitatively different from Brownian motion and can introduce non-diffusive effects, on average the system appears simply diffusive.Comment: 13 pages, 20 figures (accepted to Phys. Rev. E