10 research outputs found
Systemic treatment with pulsed electromagnetic fields do not affect bone microarchitecture in osteoporotic rats
- Author
- A Madroñero
- AB Castillo
- AT Barker
- B Mollon
- BD Adams
- BJ Punt
- C Sert
- CT Rubin
- D Jing
- E Fukada
- F Tabrah
- FL Tabrah
- GB Holmes Jr
- Harrie Weinans
- HH Guerkov
- HR Gossling
- Jacqueline C. van der Linden
- Jan A. N. Verhaar
- Jan H. Waarsing
- JH Jansen
- JH Waarsing
- K Chang
- K Nie
- K Takayama
- KS Eyres
- LK Saxon
- M Hinsenkamp
- M Hinsenkamp
- M Schnoke
- MG Hinsenkamp
- NB Watts
- Olav P. van der Jagt
- R Rizzoli
- RJ Fitzsimmons
- RK Aaron
- SM Tanaka
- T Bodamyali
- TJ Bray
- TM Skerry
- XL Griffin
- Z Schwartz
- ZB Friedenberg
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/07/2012
- Field of study
Purpose: Pulsed electromagnetic fields (PEMF) are currently used in the treatment of spinal fusions and non-unions. There are indications that PEMF might also be effective in the treatment of osteoporosis. In this study we examined whether whole-body PEMF treatment affects the bone microarchitecture in an osteoporotic rat model. Methods: Twenty-week-old female rats were ovariectomised (n020). Four different PEMF treatment protocols based on previous experimental studies and based on clinically used PEMF signals were examined (2 h/day, 5 days/week). A control group did not receive PEMF. At zero, three and six weeks cancellous and cortical bone architectural changes at the proximal tibia were evaluated using in vivo microCT scanning. Results: PEMF treatment did not induce any changes in cancellous or cortical bone compared to untreated controls. Conclusions: Although previous studies have shown strong effects of PEMF in osteoporosis we were unable to demonstrate this in any of the treatment protocols. Using in vivo microCT scanning we were able to identify small bone changes in time. Subtle differences in the experimental setup might explain the differences in study outcomes in the literature. Since PEMF treatment is safe, future experimental studies on the effect of PEMF on bone can better be performed directly on humans, eliminating the potential translation issues between animals and humans. In this study we found no support for the use of PEMF in the treatment of osteoporosis
How ELISPOT Morphology Reflects on the Productivity and Kinetics of Cells’ Secretory Activity
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Electromagnetic fields do not affect bone micro-architecture in osteoporotic rats
- Author
- Publication venue
- 'British Editorial Society of Bone & Joint Surgery'
- Publication date
- Field of study
Biophysical Stimulation with Pulsed Electromagnetic Fields in Avascular Necrosis of the Femur Head
- Author
- BC Lluch
- CAL Bassett
- CAL Bassett
- DG Mithchell
- ES Musso
- FS Santori
- G Grant
- G Scott
- GC Traina
- GC Traina
- GI Mammi
- GP Ameia Yen-Patton
- HH Guerkov
- JR Lieberman
- K Varani
- M Hinsenkamp
- M Mattei De
- MD Mont
- ME Steinberg
- ME Steinberg
- R Capanna
- R Savini
- RJ Fitzsimmons
- RK Aaron
- RK Aaron
- RK Aaron
- RK Aaron
- RP Ficat
- SF Cherian
- SW Smith
- T Kokubo
- TD Brown
- V Cané
- V Sollazzo
- WJW Sharrard
- Y Takatori
- Publication venue
- Spinger-Verlag
- Publication date
- 01/01/2004
- Field of study
Biophysical Stimulation with Pulsed Electromagnetic Fields in Avascular Necrosis of the Femur Head
- Author
- BC Lluch
- CAL Bassett
- CAL Bassett
- DG Mithchell
- ES Musso
- FS Santori
- G Grant
- G Scott
- GC Traina
- GC Traina
- GI Mammi
- GP Ameia Yen-Patton
- HH Guerkov
- JR Lieberman
- K Varani
- M Hinsenkamp
- M Mattei De
- MD Mont
- ME Steinberg
- ME Steinberg
- R Capanna
- R Savini
- RJ Fitzsimmons
- RK Aaron
- RK Aaron
- RK Aaron
- RK Aaron
- RP Ficat
- SF Cherian
- SW Smith
- T Kokubo
- TD Brown
- V Cané
- V Sollazzo
- WJW Sharrard
- Y Takatori
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2004
- Field of study
Nonunion of Complex Fractures of the Limb
- Author
- A Sarmiento
- AA Martinez
- AM Abdel-Aa
- AP Houwelingen Van
- AR Agiza
- BE Chalidis
- CI Adams
- CT Brighton
- D Ring
- D Ring
- DM Ciombor
- DM Pugh
- DS Feldman
- E Ahlmann
- EC Rodriguez-Merchan
- EC Rodriguez-Merchan
- G Cierny III
- HH Guerkov
- I Kempf
- JK Oh
- LK Reed
- MD McKee
- MR Brinker
- MR Brinker
- ON Paramasivan
- P Clarke
- R Guarniero
- RB Gustilo
- RJ Weiss
- S Abhaykumar
- SA Green
- TK Cobb
- VR Patel
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Fractures of the Fifth Metatarsal
- Author
- A Kirchner
- B Chuckpaiwong
- BA Petrisor
- CM Larson
- DJ Theodorou
- FR Nelson
- G Portland
- GA Rosenberg
- GB Holmes Jr
- GE Quill Jr
- HH Guerkov
- IM Stewart
- JC DeLee
- JD Ritchie
- JG Donald
- JH Kavanaugh
- JS Torg
- JW Smith
- KE McKeon
- KJ Hunt
- L Carp
- M Fernandez Fairen
- M Goulart
- MD Breithaupt
- MJ Callaghan
- MJ O’Malley
- MJ Shereff
- MT Glasgow
- RI Jones
- RW Wright
- SJ Lawrence
- T Bodamyali
- TS Mologne
- X Li
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Electrical stimulation therapies for spinal fusions: current concepts
- Author
- A Rogozinski
- A Rubinacci
- AF Dwyer
- AJ Meril
- AM Weinstein
- AR Poynton
- B Bose
- B McKay
- BD Boyan
- CA Bassett
- CA Bassett
- CB Goodwin
- CH Lohmann
- CH Lohmann
- CT Brighton
- CT Brighton
- D Fredericks
- D Kucharzyk
- DA Bushinsky
- DG Lorich
- EG Dawson
- EL Carter
- EL Carter
- H Uludag
- H Zhuang
- HH Guerkov
- I Yasuda
- IR Reid
- J Nerubay
- J Ryaby
- JC France
- JC Gan
- Jean C. Gan
- JM Lane
- JM Toth
- JV Nepola
- JW Simmons
- JW Simmons
- K Lee
- KJ Bozic
- LM Dejardin
- M Cho
- M Di Silvestre
- M Ito
- M Laursen
- M Nagai
- MA Morone
- N Kahanovitz
- N Kahanovitz
- N Kahanovitz
- N Kahanovitz
- NA Tejano
- OM Tepper
- PA Glazer
- Paul A. Glazer
- RA Marks
- RG Geesink
- RJ Fitzsimmons
- RJ Fitzsimmons
- RJ Linovitz
- RK Aaron
- S Guizzardi
- SD Boden
- T Bodamyali
- T Bodamyali
- T Kawase
- T Sugimoto
- TL Smith
- V Mooney
- WJ Kane
- Publication venue
- Springer-Verlag
- Publication date
- Field of study
Electrical stimulation therapies have been used for more than 30 years to enhance spinal fusions. Although their positive effects on spinal fusions have been widely reported, the mechanisms of action of the technologies were only recently identified. Three types of technologies are available clinically: direct current, capacitive coupling, and inductive coupling. The latter is the basis of pulsed electromagnetic fields and combined magnetic fields. This review summarizes the current concepts on the mechanisms of action, animal and clinical studies, and cost justification for the use of electrical stimulation for spinal fusions. Scientific studies support the validity of electrical stimulation treatments. The mechanisms of action of each of the three electrical stimulation therapies are different. New data demonstrates that the upregulation of several growth factors may be responsible for the clinical success seen with the use of such technologies
Recent Advances in Biophysical stimulation of MSC for bone regeneration
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- Basset C Pawluck R, Becker R.
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- Bassett C Pilla A, Pawluk R.
- Baureus Koch CLM Sommarin M, Persson BRR, Salford LG, Eberhardt JL
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- Carroll SF Buckley CT, Kelly DJ.
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- Publication venue
- 'Indian Society for Education and Environment'
- Publication date
- Field of study
Recent Advances in Biophysical stimulation of MSC for bone regeneration
- Author
- Adamo L Garcia-Carde-AG.
- Alin M Li Z, Stoddart MJ, Yao S-J.
- Angle SR Sena K, Sumner DR, Virdi AS.
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- Bassett C Pilla A, Pawluk R.
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