56 research outputs found
Autoradiographic studies with 3H 1,25 (OH)2 vitamin D3 and 3H 25 (OH) vitamin D3 in rat parathyroid glands
How to Color a French Flag: Biologically Inspired Algorithms for Scale-Invariant Patterning
© 2020, Springer Nature Switzerland AG. In the French flag problem, initially uncolored cells on a grid must differentiate to become blue, white or red. The goal is for the cells to color the grid as a French flag, i.e., a three-colored triband, in a distributed manner. To solve a generalized version of the problem in a distributed computational setting, we consider two models: a biologically-inspired version that relies on morphogens (diffusing proteins acting as chemical signals) and a more abstract version based on reliable message passing between cellular agents. Much of developmental biology research focuses on concentration-based approaches, since morphogen gradients are an underlying mechanism in tissue patterning. We show that both model types easily achieve a French ribbon - a French flag in the 1D case. However, extending the ribbon to the 2D flag in the concentration model is somewhat difficult unless each agent has additional positional information. Assuming that cells are identical, it is impossible to achieve a French flag or even a close approximation. In contrast, using a message-based approach in the 2D case only requires assuming that agents can be represented as logarithmic or constant size state machines. We hope that our insights may lay some groundwork for what kind of message passing abstractions or guarantees, if any, may be useful in analogy to cells communicating at long and short distances to solve patterning problems. We also hope our models and findings may be of interest in the design of nano-robots
Expression, Inducers and Cellular Sources of the Chemokine MIG (CXCL 9), During Primary Herpes Simplex Virus Type-1 Infection of the Cornea
Insect epidermis: disturbance of supracellular tissue polarity does not prevent the expression of cell polarity
Modulation of vitamin D increased H2O2 production and MAC-2 expression in the bone marrow-derived macrophages by estrogen
The use of human cornea organotypic cultures to study herpes simplex virus type 1 (HSV-1)-induced inflammation
- …