82 research outputs found
Different HLA-DRB1 allele distributions in distinct clinical subgroups of sarcoidosis patients
<p>Abstract</p> <p>Background</p> <p>A strong genetic influence by the MHC class II region has been reported in sarcoidosis, however in many studies with different results. This may possibly be caused by actual differences between distinct ethnic groups, too small sample sizes, or because of lack of accurate clinical subgrouping.</p> <p>Subjects and methods</p> <p>In this study we HLA typed a large patient population (n = 754) recruited from one single centre. Patients were sub-grouped into those with Löfgren's syndrome (LS) (n = 302) and those without (non-Löfgren's) (n = 452), and the majority of them were clinically classified into those with recovery within two years (resolving) and those with signs of disease for more than two years (non-resolving). PCR was used for determination of HLA-DRB1 alleles. Swedish healthy blood donors (n = 1366) served as controls.</p> <p>Results</p> <p>There was a dramatic difference in the distribution of HLA alleles in LS compared to non-LS patients (p = 4 à 10<sup>-36</sup>). Most notably, DRB1*01, DRB1*03 and DRB1*14, clearly differed in LS and non-LS patients. In relation to disease course, DRB1*07, DRB1*14 and DRB1*15 generally associated with, while DRB1*01 and DRB1*03 protected against, a non-resolving disease. Interestingly, the clinical influence of DRB1*03 (good prognosis) dominated over that of DRB1*15 (bad prognosis).</p> <p>Conclusions</p> <p>We found several significant differences between LS and non-LS patients and we therefore suggest that genetic association studies in sarcoidosis should include a careful clinical characterisation and sub-grouping of patients, in order to reveal true genetic associations. This may be particularly accurate to do in the heterogeneous non-LS group of patients.</p
Mycobacterial ESAT-6 and katG are Recognized by Sarcoidosis CD4+ T Cells When Presented by the American Sarcoidosis Susceptibility Allele, DRB1*1101
The socio-logic of knowledge-in-formation between discovery and error: some considerations from ânormal scienceâ under exceptional conditions
A sociology of knowledge of a specific kind, namely that emerging from
observations on the work of scientific thought collectives, is what Thomas Kuhn
acknowledges as Ludwik Fleckâs (Denkstile und Tatsachen. Gesammelte Schriften
und Zeugnisse, Suhrkamp, Berlin, 1936) influence on his own Structure of Scientific
Revolutions (1962). Yet the relationship between thought and collective that turns
out to be one of the central problematics in Fleckâs thought, remains troubling to
Kuhn. The reservations expressed by Kuhn go to the core of Fleckâs conceptualization
of the structures, roles, scientific achievements, illusions, and errors of thought
collectives, as well as to the sociology of knowledge with which he is credited, but
which remains a theoretical blindspot. I would here like to take a closer look at this
problematic, with a view to specifying the nature and the dynamic of a âsociology of
knowledgeâ that a leading thought would engender in a scientific collective, in its
refractions between internal and external conditions of knowledge formation,
operationalized under conditions of scientific work in Nazi concentration camps, as
they were retrospectively recounted by Fleck (Cognition and fact: material on
Ludwik Fleck, D. Reidel, Dordrecht, 1946).http://link.springer.com/journal/110592015-12-31hb201
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