(Z)-Ethyl 3-(2,4-difluoro­anilino)-2-(4-methoxy­phen­yl)acrylate

The title compound, C18H17F2NO3, consists of three individually planar subunits, namely two benzene rings and one amino­acrylate group. The amino­acrylate group forms dihedral angles of 5.92 (7) and 50.21 (6)° with the difluoro and methoxy benzene rings, respectively. The dihedral angle between the two benzene rings is 55.25 (7)°. The mol­ecules exhibit intra­molecular N—H⋯O and N—H⋯F inter­actions and form a three-dimensional network via inter­molecular C—H⋯O and C—H⋯π hydrogen bonds

The Impact of Consumer Materialism in China on Online Compulsive Buying Behavior

With the development of online shopping environment, the “dark side” of online shopping begins to appear. Onlinecompulsive buying behavior has always been a very important research topicin the marketing field. However, the discussion on online compulsive buying behavior by Chinese scholars is limited.Online compulsive buying behavior can be a problem for consumers, families and even harm to society. Therefore,from the perspective of materialism, this article explores the effect of materialism onthe online compulsive buying behavior, primarily through four aspects: the individual negative emotions, individual economic insecurity, family and peer influence on the individual and the individual’s life satisfaction and well-being. This paper aims to study the effects of psychological mechanism of materialismon online compulsive buying behavior, in order to find the drivers of online compulsive buying behavior. The results will be used to avoid the online compulsive buying behavior marketing activities

Note On Certain Inequalities for Neuman Means

In this paper, we give the explicit formulas for the Neuman means $N_{AH}$, $N_{HA}$, $N_{AC}$ and $N_{CA}$, and present the best possible upper and lower bounds for theses means in terms of the combinations of harmonic mean $H$, arithmetic mean $A$ and contraharmonic mean $C$.Comment: 9 page

Alleviation of Drought Stress in White Clover after Inoculation with Arbuscular Mycorrhizal Fungi

White clover is extremely susceptive to drought stress (DS), while it is not clear whether arbuscular mycorrhizal fungi (AMF) enhance drought tolerance of the plant. This study was carried out to evaluate effects of two AMF species, Funneliformis mosseae and Paraglomus occultum, on flavonoid, soluble protein, proline, and nutrient uptake in roots of white clover under well-watered (WW) and DS conditions. Root colonization by F. mosseae and P. occultum was heavily decreased by 7-week DS treatment. Mycorrhizal plants showed considerably greater biomass production in shoot, root, and total (shoot+root) than non-mycorrhizal plants, irrespective of soil water status. AMF inoculation led to significantly higher root soluble protein and proline accumulation under WW and DS and root flavonoid level under DS, regardless of AMF species. Root N, P, K and Cu concentrations were dramatically increased by mycorrhization under WW and DS, and root Ca, Mg, Fe, and Mn levels were significantly higher in AMF plants than in non-AMF plants under WW. It concluded that AMF strongly enhanced plant growth and drought tolerance of white clover by greater nutrient absorption and protective substances (soluble protein, proline, and flavonoid) accumulation

1-(2-Hydr­oxy-3,4-dimethoxy­phen­yl)-2-(4-methoxy­phen­yl)ethanone

In the title compound, C17H18O5, the pyrogallol group is almost coplanar with the mean plane of the attached carbonyl group [dihedral angle of 1.95 (13)°] and makes a dihedral angle of 56.01 (10)° with the other benzene ring. Of the three meth­oxy groups, only one is significantly twisted relative to its attached benzene ring [C—O—C—C torsion angles of 4.0 (5), 3.9 (6) and −106.3 (4)°]. Intra­molecular O—H⋯O and C—H⋯O hydrogen bonds help to establish the conformation, and the packing is consolidated by C—H⋯O inter­actions and π–π stacking interactions [centroid–centroid separation = 3.735 (2) Å]

Milk fat globule membrane protein promotes C2C12 cell proliferation through the PI3K/Akt signaling pathway

Milk fat globule membrane (MFGM) protein is known to have several health benefits, including an anti-sarcopenia effect; however, its mechanism is unclear. The aim of this study was to investigate the potential mechanism of action of the MFGM protein. The MFGM protein was extracted and separated into 4 fractions, and Fraction 2 (57 % of total MFGM) demonstrated the greatest effect on C2C12 cell proliferation. Milk fat globule-EGF factor 8 (MFG-E8) accounted for 82.35 % of the MFGM protein. The effects of whole Fraction 2 (100 μg/mL, 200 μg/mL and 300 μg/mL) on cell proliferation and morphology were measured. Using qRT-PCR or a Western blot assay, several regulatory factors, e.g., PI3K P85α, p-pI3K p85α (Tyr 508), Akt, p-Akt (Ser 473), mTOR and p-mTOR (Ser 2448), were measured in cells incubated with 200 μg/mL of Fraction 2 with or without wortmannin. The results demonstrated that Fraction 2 induced C2C12 cell proliferation in a dose-dependent manner, upregulated the mRNA expression of mTOR and p70S6K, and activated PI3K, Akt, mTOR and P70S6K phosphorylation; however, Fraction 2 inhibited FOXO3a and 4E-BP. The results demonstrate that the MFGM protein, predominantly MFG-E8, promotes cell proliferation through the PI3K/Akt/mTOR signaling pathway. This study elucidated the molecular mechanism of the MFGM protein, primarily MFG-E8, in promoting C2C12 cell proliferation via the PI3K/Akt/mTOR/P70S6K signal pathway