12 research outputs found
Advanced Techniques for Rehabilitation after Total Hip and Knee Arthroplasty: Henry Chase Marble, 1885–Unknown
This biographical sketch on Henry Chase Marble corresponds to the historic text, The Classic: Application of Curative Therapy in the Ward, available at DOI 10.1007/s11999-009-0790-1
B12 STORAGE DISEASE; COBALAMIN F DISEASE; cblF; METHYLMALONICACIDURIA DUE TO VITAMIN B12-RELEASE DEFECT)
acidemia and homocystinemia, ” Genet Med. 1999 May-Jun;1(4):146-50. 2. Andersson H, Shapria E. “Biochemical and clinical response to hydroxycobalamin versus cyanocobalamin treatment in patients with methylmalonic acidemia and homocystinuria (cblC), ” J Pediatr 1998; 132(1): 121-124. 3. Augoustides-Savvopoulou P, Mylonas I, Sewell AC, Rosenbaltt DS. “Reversible dementia in adolescent with cblC disease: Clinical heterogeneity within the same family, ” J Inher Metab Dis 1999; 22: 756- 758. 4. Baumgartner ER, Fowler B, Wendel U. “Hereditary defect of cobalamin metabolism (homocystinuria and methylmalonic aciduria) of juvenile onset, ” J Neurol Neurosurg Psychiatry 1996; 60(1): 107-108
Inhibiting inflammasomes with small molecules
Modulation of inflammasomes has tremendous therapeutic potential and is hotly pursued by industry and academia alike. Indeed a growing number of patents are emerging to protect the intellectual property in valuable compound classes. This chapter focusses specifically on the suite of small-molecule NLRP3 inflammasome inhibitors published, as specific modulation of other inflammasomes is not yet well established. Synthetic molecules, known drugs and natural product NLRP3 modulators will be detailed. Some of the molecular classes discussed have been extensively characterised through cell-based screening, pharmacokinetic profiling and therapeutic proof of concept animal models. However, many inhibitors lack rigorous studies and/or have multiple activities of which NLRP3 modulation is only one. While this is not intended as an exhaustive list, it should give an impression of the range of structures and strategies that are being used, alongside challenges encountered, in an effort to exploit the significant therapeutic benefits of targeting inflammasomes