Massive Spin 3/2 Electrodynamics

We study the general non-minimally coupled charged massive spin 3/2 model both for its low energy phenomenological properties and for its unitarity, causality and degrees of freedom behaviour. When the model is viewed as an effective theory, its parameters (after ensuring the correct excitation count) are related to physical characteristics, such as the magnetic moment g factor, by means of low energy theorems. We also provide the corresponding higher spin generalisation. Separately, we consider both low and high energy unitarity, as well as the causality aspects of our models. None (including truncated N=2 supergravity) is free of the minimal model's acausality.Comment: 23 pages, 1 figure, LaTeX and axodraw.sty, novel Majorana-type term included; results unaltere

Combined Anti-Angiogenic Therapy Targeting PDGF and VEGF Receptors Lowers the Interstitial Fluid Pressure in a Murine Experimental Carcinoma

Elevation of the interstitial fluid pressure (IFP) of carcinoma is an obstacle in treatment of tumors by chemotherapy and correlates with poor drug uptake. Previous studies have shown that treatment with inhibitors of platelet-derived growth factor (PDGF) or vascular endothelial growth factor (VEGF) signaling lowers the IFP of tumors and improve chemotherapy. In this study, we investigated whether the combination of PDGFR and VEGFR inhibitors could further reduce the IFP of KAT-4 human carcinoma tumors. The tumor IFP was measured using the wick-in-needle technique. The combination of STI571 and PTK/ZK gave an additive effect on the lowering of the IFP of KAT-4 tumors, but the timing of the treatment was crucial. The lowering of IFP following combination therapy was accompanied by vascular remodeling and decreased vascular leakiness. The effects of the inhibitors on the therapeutic efficiency of Taxol were investigated. Whereas the anti-PDGF and anti-VEGF treatment did not significantly inhibit tumor growth, the inhibitors enhanced the effect of chemotherapy. Despite having an additive effect in decreasing tumor IFP, the combination therapy did not further enhance the effect of chemotherapy. Simultaneous targeting of VEGFR and PDGFR kinase activity may be a useful strategy to decrease tumor IFP, but the timing of the inhibitors should be carefully determined

Modeling ocean-cryosphere interactions off Adélie and George V Land, East Antarctica

Ocean–cryosphere interactions along the Adélie and George V Land (AGVL) coast are investigated using a coupled ocean–sea ice–ice shelf model. The dominant feature of the Mertz Glacier Tongue (MGT), located at approximately 145°E, was a highly productive winter coastal polynya system, until its calving in February 2010 dramatically changed the regional “icescape.” This study examines the annual mean, seasonal, and interannual variabilities of sea ice production; basal melting of the MGT; ice shelves, large icebergs, and fast ice; Dense Shelf Water (DSW) export; and bottom water properties on the continental slope and rise, and assesses the impacts of the calving event. The interannual variability of the winter coastal polynya regime is dominated by the regional offshore winds and air temperature, which are linked to activity of the Amundsen Sea low pressure system. This is the main driver of the interannual variability of DSW exported from the AGVL region. The calving event led to a decrease in sea ice production that resulted in a decrease in the density of DSW export. Subsequently, there is extensive freshening downstream over the continental shelf and slope regions. In addition, it is found that the calving event causes a significant decrease in the mean melt rate of the MGT, resulting from a decrease in ocean heat flux into the cavity due to ocean circulation changes

Separably injective C*-algebras

We show that a C*-algebra is a $1$-separably injective Banach space if, and only if, it is linearly isometric to the Banach space $C_0(\Omega)$ of complex continuous functions vanishing at infinity on a substonean locally compact Hausdorff space $\Omega$