Antibacterial activity, quality and stability study of creams with new potential silver(I) complexes and in vivo case report

The aim of this study was to evaluate the antibacterial activity, quality and stability of creams (at 1 % concentration) prepared with synthesized silver(I) complexes: [Ag(Nam)2]NO3·H2O (AgNam), [Ag2(HGly)2]n(NO3)2n (AgGly) (Nam– nicotinamide, Gly – glycine) and silver(I) sulfadiazine (AgSD), which is commercially available. Antibacterial activity was evaluated by agar well diffusion method and in in vivo case. The pure silver(I) complexes as well as all three tested creams loaded with AgGly, AgSD and AgNam showed antibacterial potential. Moreover, the creams loaded with AgGly and AgNam showed higher antibacterial effects against S. aureus and B. subtilis than the cream loaded with AgSD. In terms of appearance, all cream samples were opaque and odourless, and no phase separation was observed. Creams were soluble in water (o/w emulsions) and they had a pseudoplastic behaviour. The pH of the creams was in the range of 4.87–5.75. No visible changes were observed in the case of commercially used AgSD cream during one month testing period at conditions –16 ± 1 °C; 6 ± 1 °C and 56 % relative humidity; 20 ± 1 °C and 58 % relative humidity and 40 ± 1 °C and 75 % relative humidity. However, creams containing AgGly and AgNam changed their colour depending on the tested conditions

Selected aspects of integrated environmental management

Current trends in environmental care are characterised by the principles of comprehensiveness, integration, interdisciplinarity and transregionality. It is in this spirit that the methodological, legislative and economic instruments develop, and this whole trend is referred to using the term ‘environmental management’. Environmental management constitutes a set of technical instruments and methods for managing the environment, based upon an identification of the environmental aspects of products, activities and services of any type of organisation, with the aim to adopt and implement effective proactive measures to reduce their negative impact on the environment. These measures, along with their level, relate to an organisation’s possibilities, the market’s pressure on it, and primarily with the organisation’s management’s awareness, maturity and ability to anticipate the introduction of stricter requirements. Environmental management, in the industrial production and service sectors, is one of the the most effective instruments for achieving the priority goal, which is to minimise the negative impact of production activities on the individual elements of the environment as part of the global trend of reducing the negative impact of human activity on the environment. The objective of this article is to indicate possibilities to improve the environment through the basic principles and techniques of integrated environmental management

Antibacterial activity, quality and stability study of creams with new potential silver(I) complexes and in vivo case report

The aim of this study was to evaluate the antibacterial activity, quality and stability of creams (at 1 % concentration) prepared with synthesized silver(I) complexes: [Ag(Nam)2]NO3·H2O ( AgNam), [Ag2(HGly)2]n(NO3)2n (AgGly) (Nam – nicotin-amide, Gly – glycine) and silver(I) sulfadiazine (AgSD), which is commercially available. Antibacterial activity was evaluated by agar well diffusion method and in in vivo case. The pure silver(I) complexes as well as all three tested creams loaded with AgGly, AgSD and AgNam showed antibacterial potential. Moreover, the creams loaded with AgGly and AgNam showed higher antibacterial effects against S. aureus and B. subtilis than the cream loaded with AgSD. In terms of appearance, all cream samples were opaque and odourless, and no phase separation was observed. Creams were soluble in water (o/w emulsions) and they had a pseudoplastic behaviour. The pH of the creams was in the range of 4.87–5.75. No visible changes were observed in the case of commercially used AgSD cream during one month testing period at conditions –16 ± 1 °C; 6 ± 1 °C and 56 % relative humidity; 20 ± 1 °C and 58 % relative humidity and 40 ± 1 °C and 75 % relative humidity. However, creams containing AgGly and AgNam changed their colour depending on the tested conditions