Subunit vaccine of Pasteurella multocida in veterinary uses

The present invention declaims the use of Pasteurella lipoprotein E (PlpE) as a subunit vaccine and the use of vaccines containing PlpE to protect animals from diseases caused by P. multocida. The results of vaccination and challenge experiments showed that mice and chickens immunized with PlpE were completely protected animals from challenge infection with 10.sup.1-10.sup.3 LD.sub.50 of P. multocida and no adverse effect was observed

multocida) 次單位疫苗 SUBUNIT VACCINE OF PASTEURELLA MULTOCIDA IN VETERINARY USES

本發明係關於巴斯德桿菌Pasteurellamultocida脂蛋白E(Pasteurella lipoprotein E, PlpE)用作為次單位疫苗之用途。本發明更進一步係關於用於防治巴斯德桿菌P. multocida所引起之感染疾病的疫苗組成物，其包含脂蛋白E為主要組成。經動物實驗結果發現，本發明之次單位疫苗在施打小鼠及雞隻後，能產生良好的保護效力，可耐過101-103 LD50之P. multocida感染，且施打後無不良副作用