One of These Things Is Not Quite the Same: A Comparison of the Patent Doctrine of Equivalents with Suitability for Filing an Abbreviated New Drug Application

The doctrine of equivalents as applied to chemical patents is compared to the FDA’s findings of bioequivalence in reviewing suitability petitions for filing Abbreviated New Drug Applications (ANDAs). The doctrine of equivalents provides the greatest flexibility early in the drug-development process, gradually diminishing as the product refinements become increasingly minor. Determinations of bioequivalence, however, exhibit the reverse trend as applied to analogous situations in the context of suitability petitions

A Study to Assess the United States Navy\u27s Explosive Ordinance Disposal Mobile Unit Two Emergency Medical Technician Program

Contributing goals are: 1. Determine if a difference in national curriculum standards has changed the scope of emergency medical training approved by certified EOD personnel; 2. Determine if a difference in national curriculum standards has changed the standard of emergency medical training approved by certified EOD personnel; 3. Identify the training strengths/weaknesses in the current EOD/EMT Program; 4. If any weaknesses are found, recommend for consideration a course of action for medical command personnel

Derivation and application of a Food Utility Index (FUI) for European wild boar (Sus scrofa L.)

A Food Utility Index (FUI) is presented for European wild boar (Sus scrofa L.), derived from the experimental butchery of two individuals of differing ages. The results differ from FUIs produced for other species because of the different conformation of the species. Application of the FUI to the wild boar assemblage from the Mesolithic site of Ringkloster (Denmark) allows increased understanding of field butchery, transport and processing of the animals

Analysis of the Apollo heat shield performance. Volume 2 - CHAD computer program

CHAD computer program for Apollo heat shield ablation performance analysi

An Hedonic Analysis of the Effects of Lake Water Clarity on New Hampshire Lakefront Properties

Policy makers often face the problem of evaluating how water quality affects a region's economic well-being. Using water clarity as a measure of the degree of eutrophication levels (as a lake becomes inundated with nutrients, water clarity decreases markedly), analysis is performed on sales data collected over a six-year period. Our results indicate that water clarity has a significant effect on prices paid for residential properties. Effects of a one-meter change in clarity on property value are also estimated for an average lake in four real estate market areas in New Hampshire, with effects differing substantially by area. Our findings provide state and local policy makers a measure of the cost of water quality degradation as measured by changes in water clarity, and demonstrate that protecting water quality may have a positive effect on property tax revenues.Resource /Energy Economics and Policy,

Analysis of the Apollo heat shield performance. Volume 1 - Analytical methods

Analysis of Apollo heat shield using mathematical model

Systematic alteration of ATAC-seq for profiling open chromatin in cryopreserved nuclei preparations from livestock tissues.

The use of Assay for Transposase-Accessible Chromatin (ATAC-seq) to profile chromatin accessibility has surged over the past years, but its applicability to tissues has been very limited. With the intent of preserving nuclear architecture during long-term storage, cryopreserved nuclei preparations from chicken lung were used to optimize ATAC-seq. Sequencing data were compared with existing DNase-seq, ChIP-seq, and RNA-seq data to evaluate library quality, ultimately resulting in a modified ATAC-seq method capable of generating high quality chromatin accessibility data from cryopreserved nuclei preparations. Using this method, nucleosome-free regions (NFR) identified in chicken lung overlapped half of DNase-I hypersensitive sites, coincided with active histone modifications, and specifically marked actively expressed genes. Notably, sequencing only the subnucleosomal fraction dramatically improved signal, while separation of subnucleosomal reads post-sequencing did not improve signal or peak calling. The broader applicability of this modified ATAC-seq technique was tested using cryopreserved nuclei preparations from pig tissues, resulting in NFR that were highly consistent among biological replicates. Furthermore, tissue-specific NFR were enriched for binding motifs of transcription factors related to tissue-specific functions, and marked genes functionally enriched for tissue-specific processes. Overall, these results provide insights into the optimization of ATAC-seq and a platform for profiling open chromatin in animal tissues

Faunal remains

Excavations there have uncovered the remains of a Late Helladic settlement that stood at its southern end. This volume presents an unprecedented study of a small settlement's economy and society in the Mycenaean period