The distance to a star forming region in the Outer arm of the Galaxy

We performed astrometric observations with the VLBA of WB89-437, an H2O maser source in the Outer spiral arm of the Galaxy. We measure an annual parallax of 0.167 +/- 0.006 mas, corresponding to a heliocentric distance of 6.0 +/- 0.2 kpc or a Galactocentric distance of 13.4 +/- 0.2 kpc. This value for the heliocentric distance is considerably smaller than the kinematic distance of 8.6 kpc. This confirms the presence of a faint Outer arm toward l = 135 degrees. We also measured the full space motion of the object and find a large peculiar motion of ~20 km/s toward the Galactic center. This peculiar motion explains the large error in the kinematic distance estimate. We also find that WB89-437 has the same rotation speed as the LSR, providing more evidence for a flat rotation curve and thus the presence of dark matter in the outer Galaxy.Comment: The Astrophysical Journal, accepted, 16 pages, 4 Figure

Different significance between intratumoral and peritumoral lymphatic vessel density in gastric cancer: a retrospective study of 123 cases

<p>Abstract</p> <p>Background</p> <p>Patients with gastric cancer in China have worse outcome and poorer prognosis. Tumor-induced lymphangiogenesis plays a crucial role in metastasis and tumor progression. The intratumoral and peritumoral lymphatics were supposed to have different biological effects. Three major growth factors, vascular endothelial growth factor- (VEGF)-A, VEGF-C and VEGF-D, are involved in the activation process via their receptors (VEGFRs). The purpose of current study is to investigate the significant difference between intratumoral and peritumoral lymphatic vessel density (LVD) in gastric cancer and their correlations with lymphangiogenetic growth factors.</p> <p>Methods</p> <p>Intratumoral LVD (I-LVD) and peritumoral LVD (P-LVD) of 123 patients with primary gastric cancer were assessed after staining with D2-40, and confirmed by double staining with D2-40/CD34. Proliferative activity of lymphatics endothelium was evaluated by double staining with D2-40/Ki-67. The associations were analyzed between I-LVD/P-LVD and the expression level of VEGF-A, VEGF-C, VEGF-D and the receptor VEGFR-3, which was measured by immunohistochemistry (IHC). The correlations of I-LVD and P-LVD with patient prognosis were also valued.</p> <p>Results</p> <p>(1) The peritumoral lymphatics (PTLs) were relatively enlarged with dilated lumen compared with the intratumoral lymphatics (ITLs). Increased P-LVD was significantly higher than I-LVD (<it>P </it>< 0.05). (2) P-LVD was found significantly associated with lymph node metastasis (LNM) (<it>P </it>< 0.001), lymphatic vessel invasion (LVI) (<it>P </it>< 0.001), VEGF-C (<it>P </it>= 0.003), VEGF-D expression level (<it>P </it>= 0.005) and VEGFR-3 expression level (<it>P </it>< 0.001) in peritumoral tissues, despite no significant association was found between above variants with I-LVD. However, increased I-LVD was demonstrated to be associated with decreased tumor volume (<it>P </it>< 0.001). Neither I-LVD nor P-LVD was correlated with VEGF-A expression (<it>P </it>> 0.05). (3) Proliferative activity of lymphatics endothelium was observed in PTLs, in spite of ITLs. (4) Increased P-LVD, but not I-LVD, was indicated to be an independent risk factor for lymph node metastasis by multivariate logistic regression analysis, and was related to worse disease-free survival and overall survival.</p> <p>Conclusions</p> <p>PTLs play roles in gastric cancer progression. Increased P-LVD, but not I-LVD, was significantly associated with VEGF-C/-D/VEGFR-3 system, and could be an independent risk factor for lymph node metastasis and a prognostic factor in gastric cancer.</p

First parallax measurements toward a 6.7 GHZ methanol maser with the Australian long baseline array - Distance to G 339.884-1.259

© 2015. The American Astronomical Society. All rights reserved. We have conducted the first parallax and proper motion measurements of 6.7 GHz methanol maser emission using the Australian Long Baseline Array. The parallax of G 339.8841.259 measured from five epochs of observations is 0.48 ± 0.08 mas, corresponding to a distance of - 2.1+0.4 -0.3 kpc, placing it in the Scutum spiral arm. This is consistent (within the combined uncertainty) with the kinematic distance estimate for this source at 2.5 ± 0.5 kpc using the latest Solar and Galactic rotation parameters. We find from the Lyman continuum photon flux that the embedded core of the young star is of spectral type B1, demonstrating that luminous 6.7 GHz methanol masers can be associated with high-mass stars toward the lower end of the mass range

First international consensus on the methodology of lymphangiogenesis quantification in solid human tumours

The lymphatic system is the primary pathway of metastasis for most human cancers. Recent research efforts in studying lymphangiogenesis have suggested the existence of a relationship between lymphatic vessel density and patient survival. However, current methodology of lymphangiogenesis quantification is still characterised by high intra- and interobserver variability. For the amount of lymphatic vessels in a tumour to be a clinically useful parameter, a reliable quantification technique needs to be developed. With this consensus report, we therefore would like to initiate discussion on the standardisation of the immunohistochemical method for lymphangiogenesis assessment