On image search in histopathology

Pathology images of histopathology can be acquired from camera-mounted microscopes or whole-slide scanners. Utilizing similarity calculations to match patients based on these images holds significant potential in research and clinical contexts. Recent advancements in search technologies allow for implicit quantification of tissue morphology across diverse primary sites, facilitating comparisons, and enabling inferences about diagnosis, and potentially prognosis, and predictions for new patients when compared against a curated database of diagnosed and treated cases. In this article, we comprehensively review the latest developments in image search technologies for histopathology, offering a concise overview tailored for computational pathology researchers seeking effective, fast, and efficient image search methods in their work

A self-supervised contrastive learning approach for whole slide image representation in digital pathology

Image analysis in digital pathology has proven to be one of the most challenging fields in medical imaging for AI-driven classification and search tasks. Due to their gigapixel dimensions, whole slide images (WSIs) are difficult to represent for computational pathology. Self-supervised learning (SSL) has recently demonstrated excellent performance in learning effective representations on pretext objectives, which may improve the generalizations of downstream tasks. Previous self-supervised representation methods rely on patch selection and classification such that the effect of SSL on end-to-end WSI representation is not investigated. In contrast to existing augmentation-based SSL methods, this paper proposes a novel self-supervised learning scheme based on the available primary site information. We also design a fully supervised contrastive learning setup to increase the robustness of the representations for WSI classification and search for both pretext and downstream tasks. We trained and evaluated the model on more than 6000 WSIs from The Cancer Genome Atlas (TCGA) repository provided by the National Cancer Institute. The proposed architecture achieved excellent results on most primary sites and cancer subtypes. We also achieved the best result on validation on a lung cancer classification task

Cell projection plots: A novel visualization of bone marrow aspirate cytology

Deep models for cell detection have demonstrated utility in bone marrow cytology, showing impressive results in terms of accuracy and computational efficiency. However, these models have yet to be implemented in the clinical diagnostic workflow. Additionally, the metrics used to evaluate cell detection models are not necessarily aligned with clinical goals and targets. In order to address these issues, we introduce novel, automatically generated visual summaries of bone marrow aspirate specimens called cell projection plots (CPPs). Encompassing relevant biological patterns such as neutrophil maturation, CPPs provide a compact summary of bone marrow aspirate cytology. To gauge clinical relevance, CPPs were inspected by 3 hematopathologists, who decided whether corresponding diagnostic synopses matched with generated CPPs. Pathologists were able to match CPPs to the correct synopsis with a matching degree of 85%. Our finding suggests CPPs can represent clinically relevant information from bone marrow aspirate specimens and may be used to efficiently summarize bone marrow cytology to pathologists. CPPs could be a step toward human-centered implementation of artificial intelligence (AI) in hematopathology, and a basis for a diagnostic-support tool for digital pathology workflows

Ignorance functions. An application to the calculation of the threshold in prostate ultrasound images.

In this paper, we define the concept of an ignorance function and use it to determine the best threshold with which to binarize an image. We introduce a method to construct such functions from t-norms and automorphisms. By means of these new measures, we represent the degree of ignorance of the expert when given one fuzzy set to represent the background and another to represent the object. From this ignorance degree, we assign interval-valued fuzzy sets to the image in such a way that the best threshold is given by the interval-valued fuzzy set with the lowest associated ignorance. We prove that the proposed method provides better thresholds than the fuzzy classical methods when applied to transrectal prostateultrasoundimages. The experimental results on ultrasound and natural images also allow us to determine the best choice of the function to represent the ignorance

An Heterogeneous Particle Swarm Optimizer With Predator and Scout Particles

Wepresentanewheterogeneousparticleswarmoptimization algorithm, called scouting predator-prey optimizer. The algorithm uses the interactions of the swarm with a predator particle to control the bal- ance between exploration and exploitation. Scout particles are proposed as a straightforward way of introducing new exploratory behaviors into the swarm. These can range from new heuristics that globally improve the algorithm to modifications based on problem specific knowledge. The scouting predator-prey optimizer is compared with several variations of both particle swarm and differential evolution algorithms, using a a set of benchmark functions selected to present the algorithms with different obstacles and difficulties. The experimental results suggest the new opti- mizer can outperform the other approaches over most of the benchmark problems