Entwicklung und Erprobung von Verfahren zur quantitativen Diagnostik bei der NMR-Tomographie Schlussbericht

Based on tissue-parameters T1, T2 and RHO, MRI delivers diagnostic images with high soft tissue contrast, which can be manipulated according to specific needs by using different pulse sequences. The aim of this project was to find out, whether and how it's possible to quantify these parameters and how to extract and diagnostically use quantitative information out of MR-Images. We therefore had to develop special measurement tools, a classification and management system as well as a specific expert system for brain lesions, based on a new form of knowledge representation (Phenomenological Network). To check the quality of the measurements, and to prove the portability to other systems, additional work in the area of quality control had been performed. The results of the clincial evaluation showed that quantitative parameters can be used in specific areas (i.e. therapy control, Grave's disease). Because of the overlapping of tissue parameters and great differences in the accuracy of the machines together with field strength dependent effects, an ''automatic diagnosis'' does not seem realistic for the near future. Good results could be shown by using semiquantitative morphological parameters with the expert system for brain lesions. (orig.)SIGLEAvailable from TIB Hannover: F93B1054 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Forschung und Technologie (BMFT), Bonn (Germany)DEGerman