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Lipophilic Triphenylphosphonium Cations as Tools in Mitochondrial Bioenergetics and Free Radical Biology
Lipophilic phosphonium cations were first used to investigate mitochondrial biology by Vladimir Skulachev and
colleagues in the late 1960s. Since then, these molecules have become important tools for exploring mitochondrial bioener
getics and free radical biology. Here we review why these molecules are useful in mitochondrial research and outline some of the ways in which they are now being utilized