73 research outputs found
Effect of lead acetate on Sertoli cell lactate production and protein synthesis in vitro
Full text linkThe effects of lead acetate on protein synthesis and lactate production by cultures of rat Sertoli cells in vitro were studied. Sertoli cell cultures prepared from 20 day old Sprague-Dawley rats were exposed to 0.01, 0.05 and 0.10 mM lead acetate. Lactate production was significantly elevated by all concentrations of lead after 3, 6, 9 and 12 hours of exposure. Protein biosynthesis as measured by [ 3 H]-leucine incorporation was significantly depressed by 0.05 and 0.10 mM lead acetate after 2 hours of exposure. These results support the hypothesis that lead acetate may inhibit spermatogenesis by a disturbance of the metabolic activities of the Sertoli cells.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/42549/1/10565_2004_Article_BF00122696.pd
In vitro assay for cyclophosphamide-sensitivity of human tumours: the effect of 4-hydro-peroxy-cyclophosphamide on the incorporation of 3H-Uridine into the nucleic acids of human tumour cells
No full textSTUDIES ON THE KINETICS OF INITIAL CYCLE PROGRESSION IN VITRO OF ASCITES TUMOUR CELLS SUBSEQUENT TO ISOLATION FROM ASCITES FLUID
No full text
Arzneimittel fuer die Krebstherapie Entwicklung und Wirkungspruefung. Teilprojekt 2
No full textAvailable from TIB Hannover: D.Dt.F. AC 1000(44,52) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman
Tumortherapie durch Differenzierungsinduktion und Immunstimulierung mit Perhydrothiazinylphosphamidestern, einer neuen Klasse von Prodrugs fuer aktivierte Oxazaphosphorine
No full textSIGLEAvailable from TIB Hannover: D.Dt.F.QN1(7,55) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Forschung und Technologie (BMFT), Bonn (Germany)DEGerman
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