53 research outputs found
Correlations Between Charge Ordering and Local Magnetic Fields in Overdoped YBaCuO
Zero-field muon spin relaxation (ZF-SR) measurements were undertaken on
under- and overdoped samples of superconducting YBaCuO to
determine the origin of the weak static magnetism recently reported in this
system. The temperature dependence of the muon spin relaxation rate in
overdoped crystals displays an unusual behavior in the superconducting state. A
comparison to the results of NQR and lattice structure experiments on highly
doped samples provides compelling evidence for strong coupling of charge, spin
and structural inhomogeneities.Comment: 4 pages, 4 figures, new data, new figures and modified tex
The Majorana Neutrinoless Double-Beta Decay Experiment
The proposed Majorana double-beta decay experiment is based on an array of
segmented intrinsic Ge detectors with a total mass of 500 kg of Ge isotopically
enriched to 86% in 76Ge. A discussion is given of background reduction by:
material selection, detector segmentation, pulse shape analysis, and
electro-formation of copper parts and granularity. Predictions of the
experimental sensitivity are given. For an experimental running time of 10
years over the construction and operation of Majorana, a half-life sensitivity
of ~4x10^27 y (neutrinoless) is predicted. This corresponds to an effective
Majorana mass of the electron neutrino of ~0.03-0.04 eV, according to recent
QRPA and RQRPA matrix element calculations.Comment: 10 pages, 7 figure
A Hypoxia-Inducible HIF1–GAL3ST1-Sulfatide Axis Enhances ccRCC Immune Evasion via Increased Tumor Cell–Platelet Binding
Combined pancreatoduodenectomy and orthotopic liver transplantation for hepatocellular carcinoma with portal vein tumor thrombus: A case report
Equity in coronavirus disease 2019 vaccine development and deployment
The coronavirus disease 2019 pandemic exposed weaknesses in multiple domains and widened gender-based inequalities across the world. It also stimulated extraordinary scientific achievement by bringing vaccines to the public in less than a year. In this article, we discuss the implications of current vaccination guidance for pregnant and lactating women, if their exclusion from the first wave of vaccine trials was justified, and if a change in the current vaccine development pathway is necessary. Pregnant and lactating women were not included in the initial severe acute respiratory syndrome coronavirus 2 vaccine trials. Therefore, perhaps unsurprisingly, the first vaccine regulatory approvals have been accompanied by inconsistent advice from public health, governmental, and professional authorities around the world. Denying vaccination to women who, although pregnant or breastfeeding, are fully capable of autonomous decision making is a throwback to a paternalistic era. Conversely, lack of evidence generated in a timely manner, upon which to make an informed decision, shifts responsibility from research sponsors and regulators and places the burden of decision making upon the woman and her healthcare advisor. The World Health Organization, the Task Force on Research Specific to Pregnant Women and Lactating Women, and others have highlighted the long-standing disadvantage experienced by women in relation to the development of vaccines and medicines. It is uncertain whether there was sufficient justification for excluding pregnant and lactating women from the initial severe acute respiratory syndrome coronavirus 2 vaccine trials. In future, we recommend that regulators mandate plans that describe the development pathway for new vaccines and medicines that address the needs of women who are pregnant or lactating. These should incorporate, at the outset, a careful consideration of the balance of the risks of exclusion from or inclusion in initial studies, patient and public perspectives, details of “developmental and reproductive toxicity” studies, and approaches to collect data systematically from participants who are unknowingly pregnant at the time of exposure. This requires careful consideration of any previous knowledge about the mode of action of the vaccine and the likelihood of toxicity or teratogenicity. We also support the view that the default position should be a “presumption of inclusion,” with exclusion of women who are pregnant or lactating only if justified on specific, not generic, grounds. Finally, we recommend closer coordination across countries with the aim of issuing consistent public health advice
Binding of Low-Molecular-Weight Canine Factor VIII Coagulant from von Willebrand Plasma to Canine Factor VIII-Related Antigen
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