Towards a Model of Understanding Social Search

Search engine researchers typically depict search as the solitary activity of an individual searcher. In contrast, results from our critical-incident survey of 150 users on Amazon's Mechanical Turk service suggest that social interactions play an important role throughout the search process. Our main contribution is that we have integrated models from previous work in sensemaking and information seeking behavior to present a canonical social model of user activities before, during, and after search, suggesting where in the search process even implicitly shared information may be valuable to individual searchers.Comment: Presented at 1st Intl Workshop on Collaborative Information Seeking, 2008 (arXiv:0908.0583

Anomaly Inflow and Membrane Dynamics in the QCD Vacuum

Large $N_c$ and holographic arguments, as well as Monte Carlo results, suggest that the topological structure of the QCD vacuum is dominated by codimension-one membranes which appear as thin dipole layers of topological charge. Such membranes arise naturally as $D6$ branes in the holographic formulation of QCD based on IIA string theory. The polarizability of these membranes leads to a vacuum energy $\propto \theta^2$, providing the origin of nonzero topological susceptibility. Here we show that the axial U(1) anomaly can be formulated as anomaly inflow on the brane surfaces. A 4D gauge transformation at the brane surface separates into a 3D gauge transformation of components within the brane and the transformation of the transverse component. The in-brane gauge transformation induces currents of an effective Chern-Simons theory on the brane surface, while the transformation of the transverse component describes the transverse motion of the brane and is related to the Ramond-Ramond closed string field in the holographic formulation of QCD. The relation between the surface currents and the transverse motion of the brane is dictated by the descent equations of Yang-Mills theory.Comment: 22 pages, 3 figure

cAMP Pulsing of Denuded Mouse Oocytes Increases Meiotic Resumption Via Activation of AMP-activated Protein Kinase

cAMP plays a critical role in the control of oocyte maturation, as a high level of cAMP maintains oocyte arrest at the first meiotic prophase. Yet this study shows that pulsing meiotically arrested denuded oocytes (DO) with cAMP induces oocyte maturation through the activation of AMP-activated protein kinase (PRKA). Short-term (3 h) pulsing of meiotically arrested oocytes with forskolin, an adenyl cyclase (AC) activator, increased oocyte cAMP, led to elevated AMP, and induced oocyte meiotic resumption compared to oocytes continuously cultured in the control medium with or without forskolin. Western analysis showed that germinal vesicle (GV)-stage oocytes after forskolin pulsing contained increased levels of phospho-acetyl CoA carboxylase (pACACA), a primary substrate of PRKA. Pulsing oocytes with the phosphodiesterase (PDE)-sensitive cAMP analog, 8-bromo-cAMP (8-Br-cAMP), also increased pACACA and pPRKA levels in GV-stage oocytes and induced oocyte meiotic resumption. Moreover, the PRKA inhibitors, compound C and araA, prevented 8-Br-cAMP pulsing-induced maturation. The lack of effect on meiotic induction and PRKA activation when oocytes were pulsed with the PDE-resistant activators of cAMP-dependent protein kinase, Sp-cAMP-AM and Sp-5,6-DCI-cBIMPS, suggests that cAMP degradation is required for pulsing-induced maturation. Pulsing oocytes with the exchange protein directly activated by cAMP (Epac)-specific activator, 8-CPT-2′-O-Me-cAMP, had no stimulatory effect on oocyte maturation, suggesting Epac is not involved in the pulsing-induced maturation. Taken together, these data support the idea that a transient increase in oocyte cAMP can induce meiotic resumption via activation of PRKA

Entanglement transformation between sets of bipartite pure quantum states using local operations

Alice and Bob are given an unknown initial state chosen from a set of pure quantum states. Their task is to transform the initial state to a corresponding final pure state using local operations only. We prove necessary and sufficient conditions on the existence of such a transformation. We also provide efficient algorithms that can quickly rule out the possibility of transforming a set of initial states to a set of final states.Comment: 19 pages, 1 figure, minor revision, to appear in J.Math.Phy

Destruction of Neel order and appearance of superconductivity in electron-doped cuprates by oxygen annealing process

We use thermodynamic and neutron scattering measurements to study the effect of oxygen annealing on the superconductivity and magnetism in Pr$_{0.88}$LaCe$_{0.12}$CuO$_{4-\delta}$. Although the transition temperature $T_c$ measured by susceptibility and superconducting coherence length increase smoothly with gradual oxygen removal from the annealing process, bulk superconductivity, marked by a specific heat anomaly at $T_c$ and the presence of a neutron magnetic resonance, only appears abruptly when $T_c$ is close to the largest value. These results suggest that the effect of oxygen annealing must be first determined in order to establish a Ce-doping dependence of antiferromagnetism and superconductivity phase diagram for electron-doped copper oxides.Comment: 5 pages, 4 figures, accepted by Phys. Rev.

Discrimination between pure states and mixed states

In this paper, we discuss the problem of determining whether a quantum system is in a pure state, or in a mixed state. We apply two strategies to settle this problem: the unambiguous discrimination and the maximum confidence discrimination. We also proved that the optimal versions of both strategies are equivalent. The efficiency of the discrimination is also analyzed. This scheme also provides a method to estimate purity of quantum states, and Schmidt numbers of composed systems

Supersymmetric Runge-Lenz-Pauli vector for Dirac vortex in topological insulators and graphene

The Dirac mass-vortex at the surface of a topological insulator or in graphene is considered. Within the linear approximation for the vortex amplitude's radial dependence, the spectrum is a series of degenerate bound states, which can be classified by a set of accidental SU(2) and supersymmetry generators (I. F. Herbut and C.-K. Lu, Phys. Rev. B 83 125412 (2011)). Here we discuss further the properties and manifestations of the supersymmetry of the vortex Hamiltonian, and point out some interesting analogies to the Runge-Lenz-Pauli vector in the non-relativistic hydrogen atom. Symmetry breaking effects due to a finite chemical potential, and the Zeeman field are also analyzed. We find that a residual accidental degeneracy remains only in the special case of equal magnitudes of both terms, whereas otherwise it becomes removed entirely.Comment: revised version with added reference and a new paragraph on interpretation of two-velocity Weyl fermions realized in 2D optical lattice; to appear in J Phys

AMPK Regulation of Mouse Oocyte Meiotic Resumption in Vitro

We have previously shown that the adenosine analog 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR), an activator of AMP-activated protein kinase (AMPK), stimulates an increase in AMPK activity and induces meiotic resumption in mouse oocytes [Downs, S.M., Hudson, E.R., Hardie, D.G., 2002. A potential role for AMP-activated protein kinase in meiotic induction in mouse oocytes. Dev. Biol, 245, 200–212]. The present study was carried out to better define a causative role for AMPK in oocyte meiotic maturation. When microinjected with a constitutively active AMPK, about 20% of mouse oocytes maintained in meiotic arrest with dibutyryl cAMP (dbcAMP) were stimulated to undergo germinal vesicle breakdown (GVB), while there was no effect of catalytically dead kinase. Western blot analysis revealed that germinal vesicle (GV)-stage oocytes cultured in dbcAMP-containing medium plus AICAR possessed elevated levels of active AMPK, and this was confirmed by AMPK assays using a peptide substrate of AMPK to directly measure AMPK activity. AICAR-induced meiotic resumption and AMPK activation were blocked by compound C or adenine 9-beta-d-arabinofuranoside (araA, a precursor of araATP), both inhibitors of AMPK. Compound C failed to suppress adenosine uptake and phosphorylation, indicating that it did not block AICAR action by preventing its metabolism to the AMP analog, ZMP. 2′-Deoxycoformycin (DCF), a potent adenosine deaminase inhibitor, reversed the inhibitory effect of adenosine on oocyte maturation by modulating intracellular AMP levels and activating AMPK. Rosiglitazone, an anti-diabetic agent, stimulated AMPK activation in oocytes and triggered meiotic resumption. In spontaneously maturing oocytes, GVB was preceded by AMPK activation and blocked by compound C. Collectively, these results support the proposition that active AMPK within mouse oocytes provides a potent meiosis-inducing signal in vitro