7 research outputs found
Renormalization group approach of itinerant electron systems near the Lifshitz point
Using the renormalization approach proposed by Millis for the itinerant
electron systems we calculated the specific heat coefficient for
the magnetic fluctuations with susceptibility near the Lifshitz point. The constant value
obtained for and the logarithmic temperature dependence, specific
for the non-Fermi behavior, have been obtained in agreement with the
experimental dat.Comment: 6 pages, Revte
The NOX toolbox: validating the role of NADPH oxidases in physiology and disease
Reactive oxygen species (ROS) are cellular signals but also disease triggers; their relative excess (oxidative stress) or shortage (reductive stress) compared to reducing equivalents are potentially deleterious. This may explain why antioxidants fail to combat diseases that correlate with oxidative stress. Instead, targeting of disease-relevant enzymatic ROS sources that leaves physiological ROS signaling unaffected may be more beneficial. NADPH oxidases are the only known enzyme family with the sole function to produce ROS. Of the catalytic NADPH oxidase subunits (NOX), NOX4 is the most widely distributed isoform. We provide here a critical review of the currently available experimental tools to assess the role of NOX and especially NOX4, i.e. knock-out mice, siRNAs, antibodies, and pharmacological inhibitors. We then focus on the characterization of the small molecule NADPH oxidase inhibitor, VAS2870, in vitro and in vivo, its specificity, selectivity, and possible mechanism of action. Finally, we discuss the validation of NOX4 as a potential therapeutic target for indications including stroke, heart failure, and fibrosis
Critical scaling of the magnetization and magnetostriction in the weak itinerant ferromagnet UIr.
International audienc