A rare cause of acute ST-elevation myocardial infarction:case report of native aortic valve thrombosis

Background One to 13% of all patients with the clinical diagnosis of an acute coronary syndrome (ACS) show no evidence of significant obstructive coronary artery disease on angiography. Less common causes should be considered in those situations. A very rare cause of ACS is native aortic valve thrombosis. Case summary A 69-year-old previously healthy woman presented with acute chest pain. The electrocardiogram showed an anterolateral ST-elevation myocardial infarction (STEMI). She was immediately transferred for primary percutaneous coronary intervention. Shortly after arriving in hospital her condition deteriorated, with development of cardiogenic shock necessitating cardiopulmonary resuscitation. A coronary angiogram was performed during resuscitation that did not reveal any obstructive coronary artery disease. Echocardiography showed no pericardial effusion, no significant left-sided valve pathology, no signs of an aortic dissection or pulmonary embolism. She died of cardiogenic shock of unknown cause. Permission for autopsy was obtained. Pathologic examination revealed a large anterolateral myocardial infarction caused by a mass attached to the bottom of the left coronary cusp of the native aortic valve, which was large enough to occlude the ostium of the left main coronary artery. Microscopic analysis showed a thrombus of unknown origin. The aortic valve itself showed no signs of pathology. Discussion An ST-elevation myocardial infarction due to native aortic valve thrombosis is a rare condition, especially when there are no significant valvular abnormalities. This case demonstrates that thrombosis can develop in an apparently healthy middle-aged woman without any history of thrombotic disease

Tradução e validação para a língua portuguesa da escala de graduação da síndrome das pernas inquietas do Grupo Internacional do Estudo da Síndrome das Pernas Inquietas

BACKGROUND: Restless legs syndrome (RLS) is a chronic sensory-motor disorder characterized by unpleasant limb sensations and an irresistible urge to move. The International Restless Legs Syndrome Study Group developed the Restless Legs Syndrome Rating Scale (IRLS) to assess the severity of RLS symptoms. The objective of this study was to translate and validate the IRLS into Brazilian Portuguese. METHOD: The IRLS was translated into Brazilian Portuguese, analyzed, back translated to English, and compared to the original version. It was applied to 10 patients for cultural verification. The language was adjusted and the final version was administered to 30 patients (13 male, mean age 58.88±14.82). RESULTS: There was correlation among the IRLS evaluation of three experts. Many linguistic adaptations were required to achieve cultural adequacy and the Cronbach's alpha coefficient showed reliability of 80%. CONCLUSION: IRLS was translated, adapted, and validated to Brazilian Portuguese language, showing good reliability and validity.INTRODUÇÃO: A síndrome das pernas inquietas (SPI) é uma doença crônica, sensório-motora, caracterizada por sensações desagradáveis nos membros e uma urgência em movimentá-los. O Grupo Internacional de Estudos da Síndrome das Pernas Inquietas desenvolveu a Escala de Graduação da Síndrome das Pernas Inquietas (EGSPI) para avaliar a gravidade dos sintomas da SPI. OBJETIVO: Traduzir, adaptar culturalmente e validar a EGSPI para o português do Brasil. MÉTODO: A escala foi vertida para o português, analisada, vertida novamente para o inglês e comparada com a versão original. Foi aplicada em 10 pacientes para adequação cultural. A linguagem foi ajustada e a versão final foi aplicada em 30 pacientes (13 homens, idade média de 58,88±14,82). RESULTADOS: Houve correlação da aplicação da escala entre três avaliadores. Foram necessárias adaptações lingüísticas para adequação cultural e o alfa de Chronbach mostrou confiabilidade de 80%. CONCLUSÃO: A EGSPI foi traduzida, adequada e validada para o português do Brasil, com boa validade e confiabilidade.Federal University of São Paulo Department of NeurologyFederal University of São Paulo Department of MedicineFederal University of São Paulo Hospital São Paulo Sleep LaboratoryUNIFESP, Department of NeurologyUNIFESP, Department of MedicineUNIFESP, Hospital São Paulo Sleep LaboratorySciEL

Reasoning about external environment from web sources.

Most organizations approach internal and external challenges with a varied degree of effectiveness. One of their biggest challenges is the ability toidentify and respond appropriately to changes in their external environments. These changes affect not only their technological choices, but also their internal structures and cultures. In this context, we have seen an increasing demand for computational tools capable not only to support information storage but also to help in reasoning about the organizational environment. In particular, it is observed that the availability of a huge set of information in the Web offers a new opportunity to learn and reason about the organizational context. In this paper we present an empirical model to proceed the knowledge extraction from Web sources and support the reasoning process in the Competitive Intelligence domain

Evaluation of nitrogen fixation and soil microorganisms in soybean under conventional and minimal cultivation regimes

A greenhouse experiment was set up to evaluate the effect of different cultural practices on the activity of Bradyrhizobium japonicum and of other soil microorganisms involved in nutrient cycling. The soil used was from a field experiment that consisted of continuous soybean or corn-soybean rotations as summer crops, with oats or Crotalaria juncea as winter crops. Treatments totaled eight cropping system regimes includig the coventional and minimal cultivation. Soil from a nearby natural forest was used as control. There were six replicate pots for each treatment, three of which were additionally inoculated with K japonicum inoculum when soybeans were sown. Plants were harvested at flowering and shoot dry matter and nitrogen concentration were determined, as well as nodule number, nodule weight and percent mycorrhizal colonization of roots. Soil samples from each field treatment that had been kept in the refrigerator were evaluated to determine the total number of bacteria, fungi, cellulolytic microorganisms and nitrifying bacteria. Soybeans grown in soil from minimal cultivation plots and from crop rotations demonstrated significantly greater nodulation and larger cellulolytic populations. Other microbial groups were not highly affected. Percent mycorrhizal infection of roots was extremely low in all treatments, probably due to the high available phosphate levels in all soils.Para avaliar o efeito do manejo do solo e de culturas sobre a atividade de Bradyrhizobium japonicum e de outros microrganismos importantes na ciclagem de nutrientes do solo, montou-se um experimento em casa de vegetação utilizando solo de um ensaio de campo com sistemas de manejo de resíduos e preparo bem distintos, como plantio direto e preparo convencional com arado de discos e diferentes rotações de cultura. O solo é um latossolo roxo distrófico, A moderado, textura argilosa. As culturas utilizadas no ensaio de campo foram soja contínua e em rotação com milho, sempre após aveia preta e Crolalaria juncea no outono-inverno, perfazendo portanto oito sistemas de manejo. Como testemunha, utilizou-se o solo de uma mata localizada próxima do experimento de campo. Prepararam-se seis vasos com solo de cada tratamento, sendo que em três foi semeada soja com sementes inoculadas com B. japonicum e nos outros três soja sem inoculação. No início do florescimento fez-se a colheita das plantas para análise de N na parte aérea, determinação dos nódulos e micorrização. Em amostras de solo de todos os tratamentos, guardadas em geladeira, fez-se a quantificação de bactérias e fungos totais, bem como de microrganismos celulolíticos, amonifícadores, nitritadores e nitratadores. Os resultados obtidos revelaram que o solo do plantio direto e o sistema de rotação levaram a significativos aumentos da nodulação. O solo do plantio direto apresentou também maiores populações de celulolíticos, não havendo diferença para outros tipos de microrganismos. Não houve diferença entre tratamentos para a micorrização, que apresentou valores muito baixos, provavelmente devido ao alto nível de fósforo no solo

BRS Antares e BRS Facual novas cultivares de algodão indicadas para o Estado de Rondônia.

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Estudos sobre a nutrição mineral do arroz: XXIV. Absorção e redistribuição do radiofósforo nas variedades L - 45, Dourado Precoce e Penatie

Root and leaf uptake of P32 was studied using upland rice cultivars, namely: L-45, Dourado Precoce and Penatie. Significant differences in absorption were observed among varieties. Except in the case of L-45 in_ tact plants were able to absorb more phosphorus than excised roots. The dual mechanism of absorption was observed, one operating within the range of 1-5 umoles in the external solution and the second one in that of 10² to 10(4) micromoles. When added to the solution of either monoammonium or diammonium phosphate urea increased foliar uptake. In the presence of the second source urea helped the transport to other organs of the plant. Highest rate of long distance transport was observed in the case of cv. Penatie, the lowest taking place in the variety Dourado Precoce.Foram observadas diferenças significativas na absorção do P32 em função do tempo de contacto para as cultivares L-45, Dourado Precoce e Penatie. Exceção feita no caso da L- 45 as plantas inteiras absorvem mais que as raízes destacadas. 0 mecanismo duplo de absorção atuou no caso das três variedades, uma na faixa de 1-5 umoles de H2PO-4 e outro na de 10² Cn a 10(4) umoles. A presença de uréia na solução aumenta a absorção do P fornecido por via foliar. Quando se empregou fosfato diamônico como fonte de fósforo houve maior transporte do elemento, em presença de uréia, da folha tratada para os outros órgãos da planta. 0 transporte foi maior no caso da cv. Penatie, sendo menor no caso da cv. L-45 e muito pequeno na variedade Dourado Precoce

Novel fibrin-fibronectin matrix accelerates mice skin wound healing

Plasma fibrinogen (F1) and fibronectin (pFN) polymerize to form a fibrin clot that is both a hemostatic and provisional matrix for wound healing. About 90% of plasma F1 has a homodimeric pair of γ chains (γγF1), and 10% has a heterodimeric pair of γ and more acidic γ′ chains (γγ′F1). We have synthesized a novel fibrin matrix exclusively from a 1:1 (molar ratio) complex of γγ′F1 and pFN in the presence of highly active thrombin and recombinant Factor XIII (rFXIIIa). In this matrix, the fibrin nanofibers were decorated with pFN nanoclusters (termed γγ′F1:pFN fibrin). In contrast, fibrin made from 1:1 mixture of γγF1 and pFN formed a sporadic dis- tribution of “pFN droplets” (termed γγF1+pFN fibrin). The γγ′F1:pFN fibrin enhanced the adhesion of primary human umbilical vein endothelium cells (HUVECs) relative to the γγF1+FN fibrin. Three dimensional (3D) culturing showed that the γγ′F1:pFN complex fibrin matrix enhanced the proliferation of both HUVECs and primary human fibroblasts. HUVECs in the 3D γγ′F1:pFN fibrin exhibited a starkly enhanced vascular mor- phogenesis while an apoptotic growth profile was observed in the γγF1+pFN fibrin. Relative to γγF1+pFN fibrin, mouse dermal wounds that were sealed by γγ′F1:pFN fibrin exhibited accelerated and enhanced healing. This study suggests that a 3D pFN presentation on a fibrin matrix promotes wound healing