An ant colony optimization approach for maximizing the lifetime of heterogeneous wireless sensor networks

Maximizing the lifetime of wireless sensor networks (WSNs) is a challenging problem. Although some methods exist to address the problem in homogeneous WSNs, research on this problem in heterogeneous WSNs have progressed at a slow pace. Inspired by the promising performance of ant colony optimization (ACO) to solve combinatorial problems, this paper proposes an ACO-based approach that can maximize the lifetime of heterogeneous WSNs. The methodology is based on finding the maximum number of disjoint connected covers that satisfy both sensing coverage and network connectivity. A construction graph is designed with each vertex denoting the assignment of a device in a subset. Based on pheromone and heuristic information, the ants seek an optimal path on the construction graph to maximize the number of connected covers. The pheromone serves as a metaphor for the search experiences in building connected covers. The heuristic information is used to reflect the desirability of device assignments. A local search procedure is designed to further improve the search efficiency. The proposed approach has been applied to a variety of heterogeneous WSNs. The results show that the approach is effective and efficient in finding high-quality solutions for maximizing the lifetime of heterogeneous WSNs

The emerging role of autophagy in Parkinson's disease

Parkinson's disease (PD) is the most common neurodegenerative movement disorder that affects about 1% of the population worldwide. Despite significant advances in the identification of genetic mutations and signaling pathways that are associated with the disease, the precise mechanisms implicated in the pathophysiology of the disease are not well understood. More importantly, treatments that are effective in reversing the progression of the disease is essentially lacking. Further investigation into the pathogenic mechanisms of PD thus presents a pressing concern for neuroscientists. Recently, deregulation of the autophagic pathway is observed in the brains of PD patients and in models of PD. In this review we summarize current literature on the emerging involvement of autophagy in PD, and the implication for future development of treatment against the disorder

Particle acceleration and the origin of gamma-ray emission from Fermi Bubbles

Fermi LAT has discovered two extended gamma-ray bubbles above and below the galactic plane. We propose that their origin is due to the energy release in the Galactic center (GC) as a result of quasi-periodic star accretion onto the central black hole. Shocks generated by these processes propagate into the Galactic halo and accelerate particles there. We show that electrons accelerated up to ~10 TeV may be responsible for the observed gamma-ray emission of the bubbles as a result of inverse Compton (IC) scattering on the relic photons. We also suggest that the Bubble could generate the flux of CR protons at energies > 10^15 eV because the shocks in the Bubble have much larger length scales and longer lifetimes in comparison with those in SNRs. This may explain the the CR spectrum above the knee.Comment: 5 pages, 4 figures. Expanded version of the contribution to the 32nd ICRC, Beijing, #0589. To appear in the proceeding

IL-33 ameliorates Alzheimer’s disease-like pathology and cognitive decline

Alzheimer’s disease (AD) is a devastating condition with no known effective treatment. AD is characterized by memory loss as well as impaired locomotor ability, reasoning, and judgment. Emerging evidence suggests that the innate immune response plays a major role in the pathogenesis of AD. In AD, the accumulation of β-amyloid (Aβ) in the brain perturbs physiological functions of the brain, including synaptic and neuronal dysfunction, microglial activation, and neuronal loss. Serum levels of soluble ST2 (sST2), a decoy receptor for interleukin (IL)-33, increase in patients with mild cognitive impairment, suggesting that impaired IL-33/ST2 signaling may contribute to the pathogenesis of AD. Therefore, we investigated the potential therapeutic role of IL-33 in AD, using transgenic mouse models. Here we report that IL-33 administration reverses synaptic plasticity impairment and memory deficits in APP/PS1 mice. IL-33 administration reduces soluble Aβ levels and amyloid plaque deposition by promoting the recruitment and Aβ phagocytic activity of microglia; this is mediated by ST2/p38 signaling activation. Furthermore, IL-33 injection modulates the innate immune response by polarizing microglia/macrophages toward an antiinflammatory phenotype and reducing the expression of proinflammatory genes, including IL-1β, IL-6, and NLRP3, in the cortices of APP/PS1 mice. Collectively, our results demonstrate a potential therapeutic role for IL-33 in AD

GRBs Optical follow-up observation at Lulin observatory, Taiwan

The Lulin GRB program, using the Lulin One-meter Telescope (LOT) in Taiwan started in July 2003. Its scientific aims are to discover optical counterparts of XRFs and short and long GRBs, then to quickly observe them in multiple bands. Thirteen follow-up observations were provided by LOT between July 2003 and Feb. 2005. One host galaxy was found at GRB 031203. Two optical afterglows were detected for GRB 040924 and GRB 041006. In addition, the optical observations of GRB 031203 and a discussion of the non-detection of the optical afterglow of GRB 031203 are also reported in this article.Comment: 5 pages, 2 figure. Accepted for publication into "il nuovo cimento". Proceeding of the 4th Rome GRB conference, eds. L. Piro, L. Amati, S. Covino, B. Gendr

Lithium-conductive LiNbO₃ coated high-voltage LiNi₀₅Co₀₂Mn₀₃O₂ cathode with enhanced rate and cyclability

LiNi_{0.5}Co_{0.2}Mn_{0.3}O_{2} (NCM523) cathode materials can operate at extremely high voltages and have exceptional energy density. However, their use is limited by inherent structure instability during charge/discharge and exceptionally oxidizing Ni^{4+} at the surface. Herein, we have developed a citrate-assisted deposition concept to achieve a uniform lithium-conductive LiNbO_{3} coating layer on the NCM523 surface that avoids self-nucleation of Nb-contained compounds in solution reaction. The electrode–electrolyte interface is therefore stabilized by physically blocking the detrimental parasitic reactions and Ni^{4+} dissolution whilst still maintaining high Li+ conductivity. Consequently, the modified NCM523 exhibits an encouraging Li-storage specific capacity of 207.4 mAh g^{−1} at 0.2C and 128.9 mAh g^{−1} at 10C over the range 3.0–4.5 V. Additionally, a 92% capacity retention was obtained after 100 cycles at 1C, much higher than that of the pristine NCM523 (73%). This surface engineering strategy can be extended to modify other Ni-rich cathode materials with durable electrochemical performances