33 research outputs found
Grafting Hyaluronic Acid onto Gold Surface to Achieve Low Protein Fouling in Surface Plasmon Resonance Biosensors
Ultralow Fouling and Functionalizable Surface Chemistry Based on a Zwitterionic Polymer Enabling Sensitive and Specific Protein Detection in Undiluted Blood Plasma
Exploiting pH-Regulated Dimer-Tetramer Transformation of Concanavalin A to Develop Colorimetric Biosensing of Bacteria
Development and Application of an Optical Biosensor Immunoassay for Aflatoxin M1 in Bovine Milk
Plasmonic Biosensor in NIR with Chalcogenide Glass Material: On the Role of Probe Geometry, Wavelength, and 2D Material
Fabrication of a Detection Platform with Boronic-Acid-Containing Zwitterionic Polymer Brush
Protein-Induced Configuration Transitions of Polyelectrolyte-Modified Liquid Crystal Droplets
Liquid crystal (LC) droplets dispersed in aqueous solution have emerged as an optical probe for sensing the adsorption and interaction of biological species at the LC/aqueous interface. In this paper, we modify the surface of 4-n-pentyl-4′-cyanobiphenyl (5CB) LC droplets by the adsorption of positively charged poly(diallyldimethylammonium chloride) (PDADMAC) and poly(ethylenimine) (PEI) with different molecular weights at the 5CB/water interface. The PDADMAC and PEI-modified 5CB droplets show a radial director configuration in aqueous solution with salt concentrations above 150 mM. The adsorption of negatively charged bovine serum albumin (BSA) on the positively charged PDADMAC and PEI-modified 5CB droplets through electrostatic interaction can induce the radial-to-bipolar configuration transition of the 5CB inside the droplets. We find that the concentration of BSA required to induce the configuration transition increases linearly with the decrease of the molecular weight of PDAMAC and PEI. Our results highlight the capability of the director configuration of LC droplets as an optical probe for sensing the interaction between proteins and polyelectrolytes at the LC/aqueous interface. © 2014 American Chemical Society