Electroweak Baryogenesis and Standard Model CP Violation

We analyze the mechanism of electroweak baryogenesis proposed by Farrar and Shaposhnikov in which the phase of the CKM mixing matrix is the only source of $CP$ violation. This mechanism is based on a phase separation of baryons via the scattering of quasiparticles by the wall of an expanding bubble produced at the electroweak phase transition. In agreement with the recent work of Gavela, Hern\'andez, Orloff and P\`ene, we conclude that QCD damping effects reduce the asymmetry produced to a negligible amount. We interpret the damping as quantum decoherence. We compute the asymmetry analytically. Our analysis reflects the observation that only a thin, outer layer of the bubble contributes to the coherent scattering of the quasiparticles. The generality of our arguments rules out any mechanism of electroweak baryogenesis that does not make use of a new source of $CP$ violation.Comment: 36 pages, in LaTeX, one LaTeX figure included, 5 others available upon request, SLAC-PUB-647

Shadowing in neutrino deep inelastic scattering and the determination of the strange quark distribution

We discuss shadowing corrections to the structure function $F_2$ in neutrino deep-inelastic scattering on heavy nuclear targets. In particular, we examine the role played by shadowing in the comparison of the structure functions $F_2$ measured in neutrino and muon deep inelastic scattering. The importance of shadowing corrections in the determination of the strange quark distributions is explained.Comment: 22 pages, 7 figure

Charge Symmetry Breaking in the Valence Quark Distributions of the Nucleon

Using a quark model, we study the effect of charge symmetry breaking on the valence quark distributions of the nucleon. The effect due to quark mass differences and the Coulomb interaction of the electrically charged quarks is calculated and, in contrast to recent claims, found to be small. In addition, we investigate the effect of charge symmetry breaking in the confining interaction, and in the perturbative evolution equations used to relate the quark model distributions to experiment. We find that both these effects are small, and that the strong charge symmetry breaking effect included in the scalar confining interactions may be distinguishable from that generated by quark mass differences.Comment: 10 pages, LaTEX, 5 Postscript figure

US Fish and Wildlife Service 1979 wetland classification: A review

In 1979 the US Fish and Wildlife Service published and adopted a classification of wetlands and deepwater habitats of the United States. The system was designed for use in a national inventory of wetlands. It was intended to be ecologically based, to furnish the mapping units needed for the inventory, and to provide national consistency in terminology and definition. We review the performance of the classification after 13 years of use. The definition of wetland is based on national lists of hydric soils and plants that occur in wetlands. Our experience suggests that wetland classifications must facilitate mapping and inventory because these data gathering functions are essential to management and preservation of the wetland resource, but the definitions and taxa must have ecological basis. The most serious problem faced in construction of the classification was lack of data for many of the diverse wetland types. Review of the performance of the classification suggests that, for the most part, it was successful in accomplishing its objectives, but that problem areas should be corrected and modification could strengthen its utility. The classification, at least in concept, could be applied outside the United States. Experience gained in use of the classification can furnish guidance as to pitfalls to be avoided in the wetland classification process

Cancer Survival and Excess Mortality Estimates among Adolescents and Young Adults in Western Australia, 1982-2004: A Population-Based Study

Background: Data are limited on cancer outcomes in adolescents and young adults. Methods: Based on data from the Western Australian Data Linkage System, this study modelled survival and excess mortality in all adolescents and young adults aged 15-39 years in Western Australia who had a diagnosis of cancer in the period 1982-2004. Relative survival and excess all-cause mortality for all cancers combined and for principal tumour subgroups were estimated, using the Ederer II method and generalised linear Poisson modelling, respectively. Results: A cancer diagnosis in adolescents and young adults conferred substantial survival decrement. However, overall outcomes improved over calendar period (excess mortality hazard ratio [HR], latest versus earliest diagnostic period: 0.52, trend <0.0001). Case fatality varied according to age group (HR, oldest versus youngest: 1.38, trend <0.0001), sex (HR, female versus male: 0.66, 95% confidence interval [CI] 0.62-0.71), ethnicity (HR, Aboriginal versus others: 1.47, CI 1.23-1.76), geographical area (HR, rural/remote versus urban: 1.13, CI 1.04-1.23) and residential socioeconomic status (HR, lowest versus highest quartile: 1.14, trend <0.05). Tumour subgroups differed substantially in frequency according to age group and sex, and were critical outcome determinants. Conclusions: Marked progressive calendar-time improvement in overall outcomes was evident. Further research is required to disentangle the contributions of tumour biology and health service factors to outcome disparities between ethno-demographic, geographic and socioeconomic subgroups of adolescents and young adults with cancer. © 2013 Haggar et al

Evidence for charge symmetry violation in parton distributions

By comparing structure functions measured in neutrino and charged lepton deep inelastic scattering, one can test the validity of parton charge symmetry. New experiments allow us to make such tests, which set rather tight upper limits on parton charge symmetry violation (CSV) for intermediate Bjorken x, but which appear to show sizable CSV effects at small x. We show that neither nuclear shadowing nor contributions from strange and antistrange quark distributions can account for the experimentally observed difference between the two structure functions. We are therefore forced to consider the possibility of a large CSV effect in the nucleon sea quark distributions. We discuss the consequences of this effect for other observables, and we propose an experiment which could detect a large CSV component in the nucleon sea.C. Boros; J. T. Londergan; A. W. Thoma

The Immune Cell Composition in Barrett's Metaplastic Tissue Resembles That in Normal Duodenal Tissue

BACKGROUND AND OBJECTIVE: Barrett's esophagus (BE) is characterized by the transition of squamous epithelium into columnar epithelium with intestinal metaplasia. The increased number and types of immune cells in BE have been indicated to be due to a Th2-type inflammatory process. We tested the alternative hypothesis that the abundance of T-cells in BE is caused by a homing mechanism that is found in the duodenum. PATIENTS AND METHODS: Biopsies from BE and duodenal tissue from 30 BE patients and duodenal tissue from 18 controls were characterized by immmunohistochemistry for the presence of T-cells and eosinophils(eos). Ex vivo expanded T-cells were further phenotyped by multicolor analysis using flowcytometry. RESULTS: The high percentage of CD4(+)-T cells (69±3% (mean±SEM/n = 17, by flowcytometry)), measured by flowcytometry and immunohistochemistry, and the presence of non-activated eosinophils found in BE by immunohistochemical staining, were not different from that found in duodenal tissue. Expanded lymphocytes from these tissues had a similar phenotype, characterized by a comparable but low percentage of αE(CD103) positive CD4(+)cells (44±5% in BE, 43±4% in duodenum of BE and 34±7% in duodenum of controls) and a similar percentage of granzyme-B(+)CD8(+) cells(44±5% in BE, 33±6% in duodenum of BE and 36±7% in duodenum of controls). In addition, a similar percentage of α4β7(+) T-lymphocytes (63±5% in BE, 58±5% in duodenum of BE and 62±8% in duodenum of controls) was found. Finally, mRNA expression of the ligand for α4β7, MAdCAM-1, was also similar in BE and duodenal tissue. No evidence for a Th2-response was found as almost no IL-4(+)-T-cells were seen. CONCLUSION: The immune cell composition (lymphocytes and eosinophils) and expression of intestinal adhesion molecule MAdCAM-1 is similar in BE and duodenum. This supports the hypothesis that homing of lymphocytes to BE tissue is mainly caused by intestinal homing signals rather than to an active inflammatory response

UNC1062, a new and potent Mer inhibitor

Abnormal activation of Mer kinase has been implicated in the oncogenesis of many human cancers including acute lymphoblastic and myeloid leukemia, non-small cell lung cancer, and glioblastoma. We have discovered a new family of small molecule Mer inhibitors, pyrazolopyrimidine sulfonamides, that potently inhibit the kinase activity of Mer. Importantly, these compounds do not demonstrate significant hERG activity in the PatchXpress assay. Through structure-activity relationship studies, 35 (UNC1062) was identified as a potent (IC50 = 1.1 nM) and selective Mer inhibitor. When applied to live tumor cells, UNC1062 inhibited Mer phosphorylation and colony formation in soft agar. Given the potential of Mer as a therapeutic target, UNC1062 is a promising candidate for further drug development