9 research outputs found
Time-Optimal Adiabatic-Like Expansion of Bose-Einstein Condensates
In this paper we study the fast adiabatic-like expansion of a one-dimensional
Bose-Einstein condensate (BEC) confined in a harmonic potential, using the
theory of time-optimal control. We find that under reasonable assumptions
suggested by the experimental setup, the minimum-time expansion occurs when the
frequency of the potential changes in a bang-bang form between the permitted
values. We calculate the necessary expansion time and show that it scales
logarithmically with large values of the expansion factor. This work is
expected to find applications in areas where the efficient manipulations of BEC
is of utmost importance. As an example we present the field of atom
interferometry with BEC, where the wavelike properties of atoms are used to
perform interference experiments that measure with unprecedented precision
small shifts induced by phenomena like rotation, acceleration, and gravity
gradients.Comment: Submitted to 51st IEEE Conference on Decision and Contro
Characterization of the genomic and immunologic diversity of malignant brain tumors through multisector analysis
Despite some success in secondary brain metastases, targeted or immune-based therapies have shown limited efficacy against primary brain malignancies such as glioblastoma (GBM). Although the intratumoral heterogeneity of GBM is implicated in treatment resistance, it remains unclear whether this diversity is observed within brain metastases and to what extent cancer cell-intrinsic heterogeneity sculpts the local immune microenvironment. Here, we profiled the immunogenomic state of 93 spatially distinct regions from 30 malignant brain tumors through whole-exome, RNA, and T-cell receptor sequencing. Our analyses identified differences between primary and secondary malignancies, with gliomas displaying more spatial heterogeneity at the genomic and neoantigen levels. In addition, this spatial diversity was recapitulated in the distribution of T-cell clones in which some gliomas harbored highly expanded but spatially restricted clonotypes. This study defines the immunogenomic landscape across a cohort of malignant brain tumors and contains implications for the design of targeted and immune-based therapies against intracranial malignancies. SIGNIFICANCE: This study describes the impact of spatial heterogeneity on genomic and immunologic characteristics of gliomas and brain metastases. The results suggest that gliomas harbor significantly greater intratumoral heterogeneity of genomic alterations, neoantigens, and T-cell clones than brain metastases, indicating the importance of multisector analysis for clinical or translational studies