The annexinopathies: a new category of diseases

AbstractThe annexins are a family of highly homologous phospholipid binding proteins, which share a four-domain structure, with one member of the family – annexin VI – having a duplication consisting of eight domains. Thus far, ten annexins have been described in mammals. Although the biological functions of the annexins have not been definitively established, two human diseases involving annexin abnormalities (‘annexinopathies’) have been identified as of the time of writing. Overexpression of annexin II occurs in the leukocytes of a subset of patients having a hemorrhagic form of acute promyelocytic leukemia. Underexpression of annexin V occurs on placental trophoblasts in the antiphospholipid syndrome and in preeclampsia. Also, an animal model has been described in which annexin VII is underexpressed and is associated with disease, but the relevance of this animal model to human disease is not yet understood. Future research is likely to elucidate additional ‘annexinopathies’

What is a certified public accountant

It seems strange to those of us who are daily performing our work as Certified Public Accountants, that the whole world should not know what we profess to be. It is true, however, that to many-otherwise intelligent and well-informed persons, the Certified Public Accountant is unknown. I have failed to find, however, in any instance, that the preparation of the Certified Public Accountant, from his very beginning to a point where his professional brethren universally would admit his claim to equal consideration before the public, has been ever so considered, and explained, that an outsider might readily understand it. To write that one must meet the legal requirements for an examination, is one thing; and to describe what these requirements are is another thing, and better suited for our purpose